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Gene · 23192

ATG4B: autophagy related 4B cysteine peptidase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATG4B: autophagy related 4B cysteine peptidase. Genes, record 23192. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23192

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Gene

Symbol
ATG4B
HGNC
Name
autophagy related 4B cysteine peptidase
HGNC
NCBI Gene ID
23192
NCBI Gene
HGNC ID
HGNC:20790
HGNC
Ensembl
ENSG00000168397
NCBI Gene
Aliases
APG4B, AUTL1, Apg4B, DKFZp586D1822, HsAPG4B, KIAA0943
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y4P1Cysteine protease ATG4B3937Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911791Q9Y4P1Espacenet
EP 4640849 A22025-10-291871Q9Y4P1Espacenet
EP 4641201 A22025-10-2912541Q9Y4P1Espacenet
EP 4630558 A22025-10-1517Q9Y4P1Espacenet
JP 2025519096 A2025-06-241871Q9Y4P1Espacenet
JP 2025517969 A2025-06-1212541Q9Y4P1Espacenet
JP 2025517970 A2025-06-1211791Q9Y4P1Espacenet
WO 2025083153 A12025-04-2449Q9Y4P1Espacenet
JP 2025062604 A2025-04-148033Q9Y4P1Espacenet
US 11793816 B22023-10-241Q9Y4P1Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants870

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATG4B papersNewest fiscal year
R35GM131919The mechanism and regulation of autophagy82025
R01DK079879Autophagy in liver injury72025
P30AG028740University of Florida Older Americans Independence Center (OAIC)62025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital62025
P30EY005722Center Core Grant for Vision Research42025
R01CA126792Autophagy and Pro-metastatic Differentiation42025
P01CA117969Genetics and Biology of Pancreatic Ductal Adenocarcinoma32025
P30CA016520Abramson Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025

1 to 10 of 870Source NIH's project files

See all 870 nih grants

Papers1,567

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CAPZ regulates endosomal-exosomal trafficking of plasma membrane PD-L1 independently of canonical autophagy.J Biol Chem202642810685PubTator, text miningPubMed
S-palmitoylation at the interface between lipophagy and macrophage immunometabolism in sepsis: mechanistic evidence and translational questions.Int Immunopharmacol202642764231PubTator, text miningPubMed
Corrigendum to "Nanochelate-based BCc1 delivery and its impact on key regulatory pathways in BALB/c breast cancer: An analysis of Beclin-1, ATG-4B, ATG-7, and mTOR expression" [Biochem. Biophys. Rep. 45 (2026) 102418].
Biochem Biophys Rep202642746130PubTator, text miningPubMed
Retraction notice to "NOX2-mediated reactive oxygen species contribute to angiotensin II-induced cardiac hypertrophy by promoting cardiomyocyte autophagy via Atg4B S-glutathionylation modification" [Int. Immunopharmacol. 162 (2025) 115163].
Int Immunopharmacol202642642307PubTator, text miningPubMed
Structure-based discovery of a novel small-molecule inhibitor of ATG4B that modulates autophagy in esophageal squamous cell carcinoma therapy.Bioorg Chem202642385395PubTator, text miningPubMed
Zerumbone Induced ROS-Mediated Autophagic Cell Death in Human Melanoma Cells: An In Vitro and In Vivo Study.Biofactors202642144730PubTator, text miningPubMed
Simultaneous quantification of intracellular ATG4B and CTSB activities using a dual-channel nanopipette to assess autophagic flux.Bioelectrochemistry202642143419PubTator, text miningPubMed
From GWAS to TWAS: multi-omics dissection of sepsis uncovers consistent impact of ATG4B across tissues.Arch Med Sci202642110597PubTator, text miningPubMed
S-palmitoylation of ATG4B facilitates the deconjugation of LC3-II to promote autophagy.Autophagy202642107007PubTator, text miningPubMed
Association of genetic variants in the autophagy gene ATG4B with asthma.medRxiv202641929293PubTator, text miningPubMed

1 to 10 of 1,567

See all 1,567 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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