Gene · 23192
ATG4B: autophagy related 4B cysteine peptidase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ATG4B: autophagy related 4B cysteine peptidase. Genes, record 23192. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23192
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y4P1 | Cysteine protease ATG4B | 393 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 11791 | Q9Y4P1 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1871 | Q9Y4P1 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 12541 | Q9Y4P1 | Espacenet |
| EP 4630558 A2 | 2025-10-15 | 17 | Q9Y4P1 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1871 | Q9Y4P1 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 12541 | Q9Y4P1 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 11791 | Q9Y4P1 | Espacenet |
| WO 2025083153 A1 | 2025-04-24 | 49 | Q9Y4P1 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 8033 | Q9Y4P1 | Espacenet |
| US 11793816 B2 | 2023-10-24 | 1 | Q9Y4P1 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants870
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ATG4B papers | Newest fiscal year |
|---|---|---|---|
| R35GM131919 | The mechanism and regulation of autophagy | 8 | 2025 |
| R01DK079879 | Autophagy in liver injury | 7 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 6 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 6 | 2025 |
| P30EY005722 | Center Core Grant for Vision Research | 4 | 2025 |
| R01CA126792 | Autophagy and Pro-metastatic Differentiation | 4 | 2025 |
| P01CA117969 | Genetics and Biology of Pancreatic Ductal Adenocarcinoma | 3 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
1 to 10 of 870Source NIH's project files
See all 870 nih grantsPapers1,567
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CAPZ regulates endosomal-exosomal trafficking of plasma membrane PD-L1 independently of canonical autophagy. | J Biol Chem | 2026 | 42810685 | PubTator, text mining | PubMed |
| S-palmitoylation at the interface between lipophagy and macrophage immunometabolism in sepsis: mechanistic evidence and translational questions. | Int Immunopharmacol | 2026 | 42764231 | PubTator, text mining | PubMed |
Corrigendum to "Nanochelate-based BCc1 delivery and its impact on key regulatory pathways in BALB/c breast cancer: An analysis of Beclin-1, ATG-4B, ATG-7, and mTOR expression" [Biochem. Biophys. Rep. 45 (2026) 102418]. | Biochem Biophys Rep | 2026 | 42746130 | PubTator, text mining | PubMed |
Retraction notice to "NOX2-mediated reactive oxygen species contribute to angiotensin II-induced cardiac hypertrophy by promoting cardiomyocyte autophagy via Atg4B S-glutathionylation modification" [Int. Immunopharmacol. 162 (2025) 115163]. | Int Immunopharmacol | 2026 | 42642307 | PubTator, text mining | PubMed |
| Structure-based discovery of a novel small-molecule inhibitor of ATG4B that modulates autophagy in esophageal squamous cell carcinoma therapy. | Bioorg Chem | 2026 | 42385395 | PubTator, text mining | PubMed |
| Zerumbone Induced ROS-Mediated Autophagic Cell Death in Human Melanoma Cells: An In Vitro and In Vivo Study. | Biofactors | 2026 | 42144730 | PubTator, text mining | PubMed |
| Simultaneous quantification of intracellular ATG4B and CTSB activities using a dual-channel nanopipette to assess autophagic flux. | Bioelectrochemistry | 2026 | 42143419 | PubTator, text mining | PubMed |
| From GWAS to TWAS: multi-omics dissection of sepsis uncovers consistent impact of ATG4B across tissues. | Arch Med Sci | 2026 | 42110597 | PubTator, text mining | PubMed |
| S-palmitoylation of ATG4B facilitates the deconjugation of LC3-II to promote autophagy. | Autophagy | 2026 | 42107007 | PubTator, text mining | PubMed |
| Association of genetic variants in the autophagy gene ATG4B with asthma. | medRxiv | 2026 | 41929293 | PubTator, text mining | PubMed |
1 to 10 of 1,567
See all 1,567 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23192
GET https://conductscience.org/api/genes/v1/23192/patents?page=2