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FLT1: fms related receptor tyrosine kinase 1

1 protein, 227 patents, 53 drugs, 2,980 trials, 7,922 NIH grants and 21,143 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFLT1HGNC
Namefms related receptor tyrosine kinase 1HGNC
NCBI Gene ID2321NCBI Gene
HGNC IDHGNC:3763HGNC
EnsemblENSG00000102755NCBI Gene
AliasesFLT, FLT-1, VEGFR-1, VEGFR1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P17948Vascular endothelial growth factor receptor 11,33812Ensembl, GeneID, HGNCUniProt

Patents 227

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4755909 A12026-06-1041P17948Espacenet
EP 4705273 A22026-03-11230P17948Espacenet
WO 2025259718 A22025-12-1840P17948Espacenet
EP 4650780 A22025-11-193159P17948Espacenet
EP 4641201 A22025-10-292722P17948Espacenet
EP 4641202 A22025-10-29160P17948Espacenet
EP 4641203 A22025-10-29105P17948Espacenet
WO 2025219562 A12025-10-23521P17948Espacenet
US 12435146 B22025-10-0790P17948Espacenet
JP 2025147176 A2025-10-065459P17948Espacenet

Drugs 53

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
4SC-203CHEMBL5314406Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
AEE-788CHEMBL587723Vascular endothelial growth factor receptor 1 inhibitorINHIBITORChEMBL
AG-13958CHEMBL3545335Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
AGN-211745CHEMBL4650436VEGFR1 mRNA rnai inhibitorRNAI INHIBITORChEMBL
AXITINIBCHEMBL1289926Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
BMS-690514CHEMBL3545396Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
BRIVANIBCHEMBL377300Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
BRIVANIB ALANINATECHEMBL270995Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
CEDIRANIBCHEMBL491473Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
CEP-11981CHEMBL2010872Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL

Trials 2980

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07594015LENVATINIBPHASE2ClinicalTrials.gov
NCT07593040LENVATINIBPHASE2ClinicalTrials.gov
NCT07591597FRUQUINTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07583589NINTEDANIBPHASE2ClinicalTrials.gov
NCT07572695SORAFENIBClinicalTrials.gov
NCT07571551LENVATINIBPHASE2ClinicalTrials.gov
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07552402FRUQUINTINIBClinicalTrials.gov
NCT07550972LENVATINIBPHASE2ClinicalTrials.gov
NCT07540832LENVATINIBPHASE1/PHASE2ClinicalTrials.gov

NIH grants 7922

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1322,025NIH's project files
P30CA008748Cancer Center Support Grant812,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition592,025NIH's project files
T32HL105324Hypertension and Cardiorenal Research Training Program382,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award282,025NIH's project files
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 2252,025NIH's project files
P30EY001792P30 Core Grant for Vision Research252,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support222,025NIH's project files
P30CA006973Regional Oncology Research Center202,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant172,025NIH's project files

Papers 21143

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42801806PubTator, text miningPubMed
42798633PubTator, text miningPubMed
42796224PubTator, text miningPubMed
42790949PubTator, text miningPubMed
42784940PubTator, text miningPubMed
42777681PubTator, text miningPubMed
42770272PubTator, text miningPubMed
42769325PubTator, text miningPubMed
42756172PubTator, text miningPubMed
42745947PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license