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FLT3: fms related receptor tyrosine kinase 3

1 protein, 147 patents, 47 drugs, 1,466 trials, 7,394 NIH grants and 22,539 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFLT3HGNC
Namefms related receptor tyrosine kinase 3HGNC
NCBI Gene ID2322NCBI Gene
HGNC IDHGNC:3765HGNC
EnsemblENSG00000122025NCBI Gene
AliasesCD135, FLK-2, FLK2, STK1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P36888Receptor-type tyrosine-protein kinase FLT399311Ensembl, GeneID, HGNCUniProt

Patents 147

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4794715 A12026-08-26177P36888Espacenet
JP 2026120541 A2026-07-2249P36888Espacenet
JP 2026082857 A2026-05-1949P36888Espacenet
JP 2026004568 A2026-01-1446482P36888Espacenet
EP 4650780 A22025-11-191043P36888Espacenet
EP 4640849 A22025-10-29114P36888Espacenet
EP 4641201 A22025-10-29734P36888Espacenet
EP 4633648 A12025-10-2264P36888Espacenet
JP 2025147176 A2025-10-0616719P36888Espacenet
JP 2025131681 A2025-09-09133P36888Espacenet

Drugs 47

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
4SC-203CHEMBL5314406Tyrosine-protein kinase receptor FLT3 inhibitorINHIBITORChEMBL
AKN-028CHEMBL4790100Tyrosine-protein kinase receptor FLT3 inhibitorINHIBITORChEMBL
AMG553CHEMBL4650295Tyrosine-protein kinase receptor FLT3 binding agentBINDING AGENTChEMBL
AMUVATINIBCHEMBL2103851Tyrosine-protein kinase receptor FLT3 inhibitorINHIBITORChEMBL
AS-602868CHEMBL129857Tyrosine-protein kinase receptor FLT3 inhibitorINHIBITORChEMBL
AST-487CHEMBL574738Tyrosine-protein kinase receptor FLT3 inhibitorINHIBITORChEMBL
AT-9283CHEMBL495727Tyrosine-protein kinase receptor FLT3 inhibitorINHIBITORChEMBL
C-1311CHEMBL338604Tyrosine-protein kinase receptor FLT3 inhibitorINHIBITORChEMBL
CDX-301CHEMBL4650387Tyrosine-protein kinase receptor FLT3 agonistAGONISTChEMBL
CEP-2563CHEMBL6069183Tyrosine-protein kinase receptor FLT3 inhibitorINHIBITORChEMBL

Trials 1466

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572695SORAFENIBClinicalTrials.gov
NCT07572695MIDOSTAURINClinicalTrials.gov
NCT07548710GILTERITINIBPHASE2ClinicalTrials.gov
NCT07517653FAMITINIBPHASE2ClinicalTrials.gov
NCT07478991QUIZARTINIBPHASE3ClinicalTrials.gov
NCT07477457SUNITINIBPHASE2ClinicalTrials.gov
NCT07466901FAMITINIBClinicalTrials.gov
NCT07463651SORAFENIBPHASE3ClinicalTrials.gov
NCT07463651GILTERITINIBPHASE3ClinicalTrials.gov
NCT07463248SORAFENIBPHASE2ClinicalTrials.gov

NIH grants 7394

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant4902,025NIH's project files
P30CA008748Cancer Center Support Grant2762,025NIH's project files
P30CA016058Cancer Center Support Grant1592,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)1172,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias1082,025NIH's project files
P30CA006973Regional Oncology Research Center992,025NIH's project files
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement742,025NIH's project files
U10CA180899Children's Oncology Group Statistics and Data Center682,025NIH's project files
U10CA180821Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension602,025NIH's project files
U10CA180882Alliance Statistics and Data Management Center482,025NIH's project files

Papers 22539

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821569PubTator, text miningPubMed
42821026PubTator, text miningPubMed
42809184PubTator, text miningPubMed
42805358PubTator, text miningPubMed
42803869PubTator, text miningPubMed
42800061PubTator, text miningPubMed
42793322PubTator, text miningPubMed
42789806PubTator, text miningPubMed
42783456PubTator, text miningPubMed
42782852PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license