Gene · 23236
PLCB1: phospholipase C beta 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PLCB1: phospholipase C beta 1. Genes, record 23236. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23236
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | 1,216 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 57895 | Q9NQ66 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6094 | Q9NQ66 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6094 | Q9NQ66 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33564 | Q9NQ66 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33564 | Q9NQ66 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 33564 | Q9NQ66 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 63290 | Q9NQ66 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 166261 | Q9NQ66 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8570 | Q9NQ66 | Espacenet |
| JP 2020508652 A | 2020-03-26 | 33564 | Q9NQ66 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,792
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PLCB1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHL000659 | ADP-ribosylation Cycles | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA043703 | Case Comprehensive Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30DK034989 | Yale Liver Center | 3 | 2025 |
| R01DK043140 | Mechanisms Leading to Adrenal Zonation | 3 | 2025 |
| R01HL068835 | Characterization of an isoform specific anticoagulant function of TFPI-alpha | 3 | 2025 |
| R35GM131686 | Investigation of Glycosylphosphatidylinositol (GPI) Anchorage and GPI-Anchored Proteins | 3 | 2025 |
| T32AI007172 | Infectious Disease/Basic Microbial Pathogenic Mechanisms | 3 | 2025 |
| U19AG023122 | Longevity Consortium | 3 | 2025 |
1 to 10 of 1,792Source NIH's project files
See all 1,792 nih grantsPapers2,436
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Obesity associated elevated leptin might contribute to paclitaxel resistance via PLCB1/IP3R1 axis in head and neck cancers. | Biochim Biophys Acta Mol Basis Dis | 2026 | 42772703 | PubTator, text mining | PubMed |
| Expanding the genotypic and phenotypic spectrum of PGAP1 deficiency: clinical and functional insights from 15 patients. | Eur J Hum Genet | 2026 | 42754667 | PubTator, text mining | PubMed |
| Combined Metabolomic and Transcriptomic Analysis Identifies Metabolic Signatures and Networks Associated with Semen Quality in Geese. | Animals (Basel) | 2026 | 42738551 | PubTator, text mining | PubMed |
| Genetic Heterogeneity in Susceptibility to Familial Thyroid Nodular Disease. | Thyroid | 2026 | 42723469 | PubTator, text mining | PubMed |
| Trio-based GWAS reveals loci associated with different forms of isolated cleft lip. | HGG Adv | 2026 | 42723286 | PubTator, text mining | PubMed |
| YAP1-Driven PLCβ1 Impairs MHC-I Antigen Presentation and Limits Anti-Tumor Immunity in Gastrointestinal Cancer. | Cancer Res | 2026 | 42627859 | PubTator, text mining | PubMed |
| SERHL regulates invasion and metastasis through KLF16-PLCB1/PRKCA signaling in gastric cancer cells. | Genes Dis | 2026 | 42620747 | PubTator, text mining | PubMed |
| The CRF‑CRFR1 Axis Mediates Prenatal Fear Stress‑Induced Hippocampal Mitochondrial Damage in Offspring via MAM Remodeling and Calcium Overload. | Cell Mol Neurobiol | 2026 | 42471538 | PubTator, text mining | PubMed |
| Phospholipase Cβ regulates negative associative memory through calcium dependent and independent mechanisms. | J Biol Chem | 2026 | 42372916 | PubTator, text mining | PubMed |
| Misannotated domains in plant databases: lessons from 'PIPLC Y-box-containing' proteins. | Trends Plant Sci | 2026 | 42025552 | PubTator, text mining | PubMed |
1 to 10 of 2,436
See all 2,436 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23236
GET https://conductscience.org/api/genes/v1/23236/patents?page=2