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Gene · 23236

PLCB1: phospholipase C beta 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLCB1: phospholipase C beta 1. Genes, record 23236. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23236

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Gene

Symbol
PLCB1
HGNC
Name
phospholipase C beta 1
HGNC
NCBI Gene ID
23236
NCBI Gene
HGNC ID
HGNC:15917
HGNC
Ensembl
ENSG00000182621
NCBI Gene
Aliases
DEE12, EIEE12, KIAA0581, PI-PLC, PLC-154, PLC-I, PLC-beta-1, PLC154, PLCB1A, PLCB1B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NQ661-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11,2160Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457895Q9NQ66Espacenet
EP 4641201 A22025-10-296094Q9NQ66Espacenet
JP 2025517969 A2025-06-126094Q9NQ66Espacenet
JP 2025032204 A2025-03-1133564Q9NQ66Espacenet
EP 4461818 A22024-11-1333564Q9NQ66Espacenet
JP 2023058610 A2023-04-2533564Q9NQ66Espacenet
US 11446398 B22022-09-2063290Q9NQ66Espacenet
JP 2022524081 A2022-04-27166261Q9NQ66Espacenet
US 11078247 B22021-08-038570Q9NQ66Espacenet
JP 2020508652 A2020-03-2633564Q9NQ66Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,792

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLCB1 papersNewest fiscal year
ZIAHL000659ADP-ribosylation Cycles42025
P30CA016672Cancer Center Support Grant32025
P30CA043703Case Comprehensive Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30DK034989Yale Liver Center32025
R01DK043140Mechanisms Leading to Adrenal Zonation32025
R01HL068835Characterization of an isoform specific anticoagulant function of TFPI-alpha32025
R35GM131686Investigation of Glycosylphosphatidylinositol (GPI) Anchorage and GPI-Anchored Proteins32025
T32AI007172Infectious Disease/Basic Microbial Pathogenic Mechanisms32025
U19AG023122Longevity Consortium32025

1 to 10 of 1,792Source NIH's project files

See all 1,792 nih grants

Papers2,436

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Obesity associated elevated leptin might contribute to paclitaxel resistance via PLCB1/IP3R1 axis in head and neck cancers.Biochim Biophys Acta Mol Basis Dis202642772703PubTator, text miningPubMed
Expanding the genotypic and phenotypic spectrum of PGAP1 deficiency: clinical and functional insights from 15 patients.Eur J Hum Genet202642754667PubTator, text miningPubMed
Combined Metabolomic and Transcriptomic Analysis Identifies Metabolic Signatures and Networks Associated with Semen Quality in Geese.Animals (Basel)202642738551PubTator, text miningPubMed
Genetic Heterogeneity in Susceptibility to Familial Thyroid Nodular Disease.Thyroid202642723469PubTator, text miningPubMed
Trio-based GWAS reveals loci associated with different forms of isolated cleft lip.HGG Adv202642723286PubTator, text miningPubMed
YAP1-Driven PLCβ1 Impairs MHC-I Antigen Presentation and Limits Anti-Tumor Immunity in Gastrointestinal Cancer.Cancer Res202642627859PubTator, text miningPubMed
SERHL regulates invasion and metastasis through KLF16-PLCB1/PRKCA signaling in gastric cancer cells.Genes Dis202642620747PubTator, text miningPubMed
The CRF‑CRFR1 Axis Mediates Prenatal Fear Stress‑Induced Hippocampal Mitochondrial Damage in Offspring via MAM Remodeling and Calcium Overload.Cell Mol Neurobiol202642471538PubTator, text miningPubMed
Phospholipase Cβ regulates negative associative memory through calcium dependent and independent mechanisms.J Biol Chem202642372916PubTator, text miningPubMed
Misannotated domains in plant databases: lessons from 'PIPLC Y-box-containing' proteins.Trends Plant Sci202642025552PubTator, text miningPubMed

1 to 10 of 2,436

See all 2,436 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23236

GET https://conductscience.org/api/genes/v1/23236/patents?page=2