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Gene · 23237

ARC: activity regulated cytoskeleton associated protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ARC: activity regulated cytoskeleton associated protein. Genes, record 23237. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23237

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Gene

Symbol
ARC
HGNC
Name
activity regulated cytoskeleton associated protein
HGNC
NCBI Gene ID
23237
NCBI Gene
HGNC ID
HGNC:648
HGNC
Ensembl
ENSG00000198576
NCBI Gene
Aliases
Arg3.1, KIAA0278, hArc
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q7LC44Activity-regulated cytoskeleton-associated protein3968Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4704813 A22026-03-115Q7LC44Espacenet
JP 2026004568 A2026-01-1436246Q7LC44Espacenet
US 12404525 B22025-09-021Q7LC44Espacenet
US 12351814 B22025-07-081Q7LC44Espacenet
US 12351815 B22025-07-081Q7LC44Espacenet
JP 2025519070 A2025-06-244Q7LC44Espacenet
JP 2025062604 A2025-04-141797Q7LC44Espacenet
EP 4526459 A22025-03-264Q7LC44Espacenet
JP 2025032204 A2025-03-1124622Q7LC44Espacenet
EP 4461818 A22024-11-1324622Q7LC44Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants3,145

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleARC papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA013330Cancer Center Support Grant82025
P50AA022538Center for Alcohol Research in Epigenetics82025
R01MH112766Investigating the mechanisms of Arc-dependent synaptic plasticity72025
P51OD011092Support for National Primate Research Center62025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)52025
U54MD007598Center for Accelerating Excellence in Translational Science (AXIS)52025
P01AG009973Cognition & Hippocampal/Cortical Systems in Aging42025
P30CA008748Cancer Center Support Grant42025
P30CA043703Case Comprehensive Cancer Center Support Grant42025

1 to 10 of 3,145Source NIH's project files

See all 3,145 nih grants

Papers3,775

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mechanistic Analysis of Albumin-Ruthenium Conjugates Reveals Redox-Sensitive Catalytic Persistence for Extracellular Prodrug Uncaging.Chembiochem202642814897PubTator, text miningPubMed
Electrical stimulation promotes structural plasticity in cortical spheroids by modulating N-cadherin-dependent collective migration and mechanotransduction.Biomed Eng Lett202642801008PubTator, text miningPubMed
Targeting neuronal injury with intranasal Arc-engineered exosomes rescues cognitive deficits in Alzheimer's disease via the mTOR-autophagy pathway.Nanomedicine202642790614PubTator, text miningPubMed
[Expression of Concern] Rapamycin‑induced miR‑30a downregulation inhibits senescence of VSMCs by targeting Beclin1.Int J Mol Med202642725387PubTator, text miningPubMed
Biophysical characterization of Arc protein-RNA interactions.Neuroreport202642712177PubTator, text miningPubMed
Human amniotic mesenchymal stromal cell-derived extracellular vesicles reprogram microglia and prevent neurodegeneration in experimental models of Alzheimer's disease.Transl Neurodegener202642711740PubTator, text miningPubMed
Virtual Cell Challenge 2026: Benchmarking zero-shot generalization across cellular contexts.Cell202642648290PubTator, text miningPubMed
In vivo and in vitro investigation of skin anti-inflammatory effect of Sumac (Rhus coriaria L.).Inflammopharmacology202642645720PubTator, text miningPubMed
From Molecules to Minds: Redefining the Power of Psychedelics and Entactogens in Treating Brain Disorders.CNS Neurol Disord Drug Targets202642613695PubTator, text miningPubMed
Results from the first clinical trial of bitopertin for steroid-relapsed/refractory Diamond-Blackfan anemia.Blood Red Cells Iron202642583025PubTator, text miningPubMed

1 to 10 of 3,775

See all 3,775 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23237

GET https://conductscience.org/api/genes/v1/23237/patents?page=2