Gene · 23239
PHLPP1: PH domain and leucine rich repeat protein phosphatase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PHLPP1: PH domain and leucine rich repeat protein phosphatase 1. Genes, record 23239. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23239
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O60346 | PH domain leucine-rich repeat-containing protein phosphatase 1 | 1,717 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents18
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 2110 | O60346 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1677 | O60346 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1677 | O60346 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2110 | O60346 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7585 | O60346 | Espacenet |
| JP 2022141755 A | 2022-09-29 | 549 | O60346 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 62203 | O60346 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 165174 | O60346 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8428 | O60346 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 7585 | O60346 | Espacenet |
1 to 10 of 18
See all 18 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,005
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PHLPP1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 18 | 2025 |
| R35GM122523 | Molecular Mechanisms of Cell Signaling | 14 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 7 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 6 | 2025 |
| T32AR056950 | Musculoskeletal Research Training Program | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P50CA092629 | SPORE in Prostate Cancer | 4 | 2025 |
1 to 10 of 1,005Source NIH's project files
See all 1,005 nih grantsPapers1,563
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity. | Postepy Kardiol Interwencyjnej | 2026 | 42598495 | PubTator, text mining | PubMed |
| PHLPP1 Regulates Inflammatory Signaling in Degenerated Nucleus Pulposus Cells in Mice and Humans. | Cells | 2026 | 42587772 | PubTator, text mining | PubMed |
| PHLPP is neither a Phosphatase nor a Tumor Suppressor. | Bioessays | 2026 | 42438210 | PubTator, text mining | PubMed |
| Tumor-enriched circRNA TAFCR1 drives cancer progression and metastasis by disrupting UBE1-dependent TRIM21-mediated CD44 ubiquitination. | Biomark Res | 2026 | 42265572 | PubTator, text mining | PubMed |
| Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. | Alzheimers Dement | 2026 | 42043782 | PubTator, text mining | PubMed |
| PLAG1-rearranged uterine mesenchymal tumours: A study of 11 cases showing distinct histological features beyond myxoid morphology. | Histopathology | 2026 | 42021529 | PubTator, text mining | PubMed |
| Novel Prognostic and Predictive miRNA Biomarkers Shape the Landscape of T Cell Dysfunction in Cancer. | J Cell Mol Med | 2026 | 41923561 | PubTator, text mining | PubMed |
| Implication of Epigenetic Alterations of ZEB1 in Colorectal Cancer (CRC) Pathogenesis and Therapy Development. | Curr Issues Mol Biol | 2026 | 41899428 | PubTator, text mining | PubMed |
| Thermodynamic and exergoeconomic analysis of a solar-assisted LiBr/H₂O ejector-absorption refrigeration system with triple-layer thermal storage. | Sci Rep | 2026 | 41857085 | PubTator, text mining | PubMed |
| Amyloid fibril polymorphism: Structural mechanisms of assembly and the links to disease. | Curr Opin Struct Biol | 2026 | 41830661 | PubTator, text mining | PubMed |
1 to 10 of 1,563
See all 1,563 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23239
GET https://conductscience.org/api/genes/v1/23239/patents