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Gene · 23239

PHLPP1: PH domain and leucine rich repeat protein phosphatase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PHLPP1: PH domain and leucine rich repeat protein phosphatase 1. Genes, record 23239. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23239

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Gene

Symbol
PHLPP1
HGNC
Name
PH domain and leucine rich repeat protein phosphatase 1
HGNC
NCBI Gene ID
23239
NCBI Gene
HGNC ID
HGNC:20610
HGNC
Ensembl
ENSG00000081913
NCBI Gene
Aliases
KIAA0606, PHLPP, PLEKHE1, PPM3A, SCOP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60346PH domain leucine-rich repeat-containing protein phosphatase 11,7170Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192110O60346Espacenet
EP 4641201 A22025-10-291677O60346Espacenet
JP 2025517969 A2025-06-121677O60346Espacenet
JP 2025517970 A2025-06-122110O60346Espacenet
JP 2024123008 A2024-09-107585O60346Espacenet
JP 2022141755 A2022-09-29549O60346Espacenet
US 11446398 B22022-09-2062203O60346Espacenet
JP 2022524081 A2022-04-27165174O60346Espacenet
US 11078247 B22021-08-038428O60346Espacenet
US 10501513 B22019-12-107585O60346Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,005

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePHLPP1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant182025
R35GM122523Molecular Mechanisms of Cell Signaling142025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant72025
P50CA097186The Pacific Northwest Prostate Cancer SPORE62025
T32AR056950Musculoskeletal Research Training Program62025
P30CA008748Cancer Center Support Grant52025
P30CA016087Cancer Center Support Grant42025
P30CA045508CSHL Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
P50CA092629SPORE in Prostate Cancer42025

1 to 10 of 1,005Source NIH's project files

See all 1,005 nih grants

Papers1,563

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity.Postepy Kardiol Interwencyjnej202642598495PubTator, text miningPubMed
PHLPP1 Regulates Inflammatory Signaling in Degenerated Nucleus Pulposus Cells in Mice and Humans.Cells202642587772PubTator, text miningPubMed
PHLPP is neither a Phosphatase nor a Tumor Suppressor.Bioessays202642438210PubTator, text miningPubMed
Tumor-enriched circRNA TAFCR1 drives cancer progression and metastasis by disrupting UBE1-dependent TRIM21-mediated CD44 ubiquitination.Biomark Res202642265572PubTator, text miningPubMed
Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.Alzheimers Dement202642043782PubTator, text miningPubMed
PLAG1-rearranged uterine mesenchymal tumours: A study of 11 cases showing distinct histological features beyond myxoid morphology.Histopathology202642021529PubTator, text miningPubMed
Novel Prognostic and Predictive miRNA Biomarkers Shape the Landscape of T Cell Dysfunction in Cancer.J Cell Mol Med202641923561PubTator, text miningPubMed
Implication of Epigenetic Alterations of ZEB1 in Colorectal Cancer (CRC) Pathogenesis and Therapy Development.Curr Issues Mol Biol202641899428PubTator, text miningPubMed
Thermodynamic and exergoeconomic analysis of a solar-assisted LiBr/H₂O ejector-absorption refrigeration system with triple-layer thermal storage.Sci Rep202641857085PubTator, text miningPubMed
Amyloid fibril polymorphism: Structural mechanisms of assembly and the links to disease.Curr Opin Struct Biol202641830661PubTator, text miningPubMed

1 to 10 of 1,563

See all 1,563 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23239

GET https://conductscience.org/api/genes/v1/23239/patents