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FLT4: fms related receptor tyrosine kinase 4

1 protein, 125 patents, 52 drugs, 3,315 trials, 3,507 NIH grants and 8,872 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFLT4HGNC
Namefms related receptor tyrosine kinase 4HGNC
NCBI Gene ID2324NCBI Gene
HGNC IDHGNC:3767HGNC
EnsemblENSG00000037280NCBI Gene
AliasesCHTD7, FLT-4, FLT41, LMPH1A, LMPHM1, PCL, VEGFR-3, VEGFR3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P35916Vascular endothelial growth factor receptor 31,3632Ensembl, GeneID, HGNCUniProt

Patents 125

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086863 A2026-05-2613P35916Espacenet
EP 4705273 A22026-03-11231P35916Espacenet
EP 4650780 A22025-11-191989P35916Espacenet
EP 4641201 A22025-10-291563P35916Espacenet
EP 4641202 A22025-10-2998P35916Espacenet
EP 4641203 A22025-10-2961P35916Espacenet
JP 2025163070 A2025-10-28387P35916Espacenet
WO 2025219562 A12025-10-23523P35916Espacenet
JP 2025147176 A2025-10-065464P35916Espacenet
JP 2025529142 A2025-09-041589P35916Espacenet

Drugs 52

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
4SC-203CHEMBL5314406Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
AG-13958CHEMBL3545335Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
AXITINIBCHEMBL1289926Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
BMS-690514CHEMBL3545396Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
BRIVANIBCHEMBL377300Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
BRIVANIB ALANINATECHEMBL270995Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
CATEQUENTINIBCHEMBL4303201Vascular endothelial growth factor receptor 3 inhibitorINHIBITORChEMBL
CEDIRANIBCHEMBL491473Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
CEP-11981CHEMBL2010872Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
CEP-5214CHEMBL150894Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL

Trials 3315

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07602101CATEQUENTINIBPHASE2ClinicalTrials.gov
NCT07594015LENVATINIBPHASE2ClinicalTrials.gov
NCT07593040LENVATINIBPHASE2ClinicalTrials.gov
NCT07591597FRUQUINTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07583589NINTEDANIBPHASE2ClinicalTrials.gov
NCT07581821CATEQUENTINIBPHASE2ClinicalTrials.gov
NCT07572695SORAFENIBClinicalTrials.gov
NCT07571551LENVATINIBPHASE2ClinicalTrials.gov
NCT07562581CATEQUENTINIBPHASE2ClinicalTrials.gov
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov

NIH grants 3507

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant782,025NIH's project files
P30CA016672Cancer Center Support Grant732,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant172,025NIH's project files
P30EY001792P30 Core Grant for Vision Research172,025NIH's project files
P30CA006973Regional Oncology Research Center142,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant132,025NIH's project files
T32CA009501Surgical Oncology Research Training Grant132,025NIH's project files
R01EY012963Mechanisms of Sensitization in High Risk Corneal Grafts122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award122,025NIH's project files
ZIAHL002541Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)112,025NIH's project files

Papers 8872

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42793248PubTator, text miningPubMed
42789362PubTator, text miningPubMed
42775509PubTator, text miningPubMed
42746480PubTator, text miningPubMed
42739253PubTator, text miningPubMed
42735790PubTator, text miningPubMed
42717534PubTator, text miningPubMed
42659620PubTator, text miningPubMed
42642422PubTator, text miningPubMed
42624826PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license