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Gene · 23308

ICOSLG: inducible T cell costimulator ligand

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ICOSLG: inducible T cell costimulator ligand. Genes, record 23308. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23308

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Gene

Symbol
ICOSLG
HGNC
Name
inducible T cell costimulator ligand
HGNC
NCBI Gene ID
23308
NCBI Gene
HGNC ID
HGNC:17087
HGNC
Ensembl
ENSG00000160223
NCBI Gene
Aliases
B7-H2, B7H2, B7RP-1, B7RP1, B7h, CD275, GL50, ICOS-L, ICOSL, IMD119, KIAA0653, LICOS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75144ICOS ligand3022Ensembl, GeneID, HGNC

Source UniProt

Patents251

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4831196 A22026-10-28494O75144Espacenet
EP 4831196 A22026-10-285O75144Espacenet
US 12624087 B22026-05-125O75144Espacenet
US 12612446 B22026-04-28447O75144Espacenet
JP 2026004568 A2026-01-1449744O75144Espacenet
JP 2026500896 A2026-01-0918O75144Espacenet
JP 2026001069 A2026-01-06516O75144Espacenet
EP 4650780 A22025-11-1911814O75144Espacenet
EP 4650780 A22025-11-1918931O75144Espacenet
WO 2025235604 A12025-11-1318O75144Espacenet

1 to 10 of 251

See all 251 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
AMG-557CHEMBL2109249ICOS ligand inhibitorINHIBITOR

Source ChEMBL

Trials6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02391259AMG-557PHASE1ClinicalTrials.gov
NCT02334306AMG-557PHASE22019-03-19ClinicalTrials.gov
NCT01683695AMG-557PHASE1ClinicalTrials.gov
NCT01493518AMG-557PHASE1ClinicalTrials.gov
NCT01389895AMG-557PHASE1ClinicalTrials.gov
NCT00774943AMG-557PHASE1ClinicalTrials.gov

NIH grants1,782

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleICOSLG papersNewest fiscal year
P30CA016672Cancer Center Support Grant222025
P30CA008748Cancer Center Support Grant132025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations82025
P30CA016359Cancer Center Support Grant72025
R01CA142779PD-1/PD-L1 modulation in cancer therapy72025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies62025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital62025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes62025
UL1TR001863Yale Clinical and Translational Science Award62025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)52025

1 to 10 of 1,782Source NIH's project files

See all 1,782 nih grants

Papers2,855

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MicroRNA-driven regulation of immunosuppressive microenvironment in hepatocellular carcinoma.Proc Natl Acad Sci U S A202642804630PubTator, text miningPubMed
Spatial transcriptomics reveals immune remodeling in lymph nodes of gastric adenocarcinoma.Clin Exp Metastasis202642754734PubTator, text miningPubMed
Structure-guided discovery of small-molecule ICOS-ICOSL antagonists that remodel intratumoral immunity and enhance anti-PD‑1 therapy in osteosarcoma.Pathol Res Pract202642586025PubTator, text miningPubMed
Nectin-4 as predictive biomarker of immune-related adverse event subtypes in adjuvant anti-programmed-death-1 treatment of melanoma.Melanoma Res202642421561PubTator, text miningPubMed
An ICOSL-armed oncolytic adenovirus activates CD4+ T cell to potentiate antitumor immunity and synergizes with anti-PD-1 or CAR-T cell therapy in colorectal cancer.BMC Med202642374450PubTator, text miningPubMed
A pan-cancer analysis of MEX3D in human tumors.Discov Oncol202642364006PubTator, text miningPubMed
Spatial multi-omics implicate the interaction between Tpex and B cells in tertiary lymphoid structures after neoadjuvant therapy.Cancer Discov202642339989PubTator, text miningPubMed
Adiposity-Associated Monocyte Costimulatory Programming in Rheumatoid Arthritis Identified by Single-Cell Transcriptomics.medRxiv202642326774PubTator, text miningPubMed
Senescent Human Liver Endothelial Cells Mediate CD4+ T Cell Recruitment via ICOSL.Immunology202642324173PubTator, text miningPubMed
Inducible T Cell Costimulator Ligand and Inducible T Cell Costimulator Stratification Identify Dichotomous Tumor Microenvironment and Guide Chemo-Immunotherapy in Small Cell Lung Cancer.MedComm (2020)202642253933PubTator, text miningPubMed

1 to 10 of 2,855

See all 2,855 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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