Gene · 23308
ICOSLG: inducible T cell costimulator ligand
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ICOSLG: inducible T cell costimulator ligand. Genes, record 23308. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23308
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O75144 | ICOS ligand | 302 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents251
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4831196 A2 | 2026-10-28 | 494 | O75144 | Espacenet |
| EP 4831196 A2 | 2026-10-28 | 5 | O75144 | Espacenet |
| US 12624087 B2 | 2026-05-12 | 5 | O75144 | Espacenet |
| US 12612446 B2 | 2026-04-28 | 447 | O75144 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 49744 | O75144 | Espacenet |
| JP 2026500896 A | 2026-01-09 | 18 | O75144 | Espacenet |
| JP 2026001069 A | 2026-01-06 | 516 | O75144 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 11814 | O75144 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 18931 | O75144 | Espacenet |
| WO 2025235604 A1 | 2025-11-13 | 18 | O75144 | Espacenet |
1 to 10 of 251
See all 251 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| AMG-557 | CHEMBL2109249 | ICOS ligand inhibitor | INHIBITOR |
Source ChEMBL
Trials6
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02391259 | AMG-557 | PHASE1 | ClinicalTrials.gov | |
| NCT02334306 | AMG-557 | PHASE2 | 2019-03-19 | ClinicalTrials.gov |
| NCT01683695 | AMG-557 | PHASE1 | ClinicalTrials.gov | |
| NCT01493518 | AMG-557 | PHASE1 | ClinicalTrials.gov | |
| NCT01389895 | AMG-557 | PHASE1 | ClinicalTrials.gov | |
| NCT00774943 | AMG-557 | PHASE1 | ClinicalTrials.gov |
NIH grants1,782
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ICOSLG papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 22 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| U01DK062422 | Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations | 8 | 2025 |
| P30CA016359 | Cancer Center Support Grant | 7 | 2025 |
| R01CA142779 | PD-1/PD-L1 modulation in cancer therapy | 7 | 2025 |
| P01CA065493 | Off-the-Shelf Immune Effector Cells for Hematological Malignancies | 6 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 6 | 2025 |
| U01DK062413 | Determining genomic and host-environment contributions to IBD phenotypes | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 5 | 2025 |
1 to 10 of 1,782Source NIH's project files
See all 1,782 nih grantsPapers2,855
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| MicroRNA-driven regulation of immunosuppressive microenvironment in hepatocellular carcinoma. | Proc Natl Acad Sci U S A | 2026 | 42804630 | PubTator, text mining | PubMed |
| Spatial transcriptomics reveals immune remodeling in lymph nodes of gastric adenocarcinoma. | Clin Exp Metastasis | 2026 | 42754734 | PubTator, text mining | PubMed |
| Structure-guided discovery of small-molecule ICOS-ICOSL antagonists that remodel intratumoral immunity and enhance anti-PD‑1 therapy in osteosarcoma. | Pathol Res Pract | 2026 | 42586025 | PubTator, text mining | PubMed |
| Nectin-4 as predictive biomarker of immune-related adverse event subtypes in adjuvant anti-programmed-death-1 treatment of melanoma. | Melanoma Res | 2026 | 42421561 | PubTator, text mining | PubMed |
| An ICOSL-armed oncolytic adenovirus activates CD4+ T cell to potentiate antitumor immunity and synergizes with anti-PD-1 or CAR-T cell therapy in colorectal cancer. | BMC Med | 2026 | 42374450 | PubTator, text mining | PubMed |
| A pan-cancer analysis of MEX3D in human tumors. | Discov Oncol | 2026 | 42364006 | PubTator, text mining | PubMed |
| Spatial multi-omics implicate the interaction between Tpex and B cells in tertiary lymphoid structures after neoadjuvant therapy. | Cancer Discov | 2026 | 42339989 | PubTator, text mining | PubMed |
| Adiposity-Associated Monocyte Costimulatory Programming in Rheumatoid Arthritis Identified by Single-Cell Transcriptomics. | medRxiv | 2026 | 42326774 | PubTator, text mining | PubMed |
| Senescent Human Liver Endothelial Cells Mediate CD4+ T Cell Recruitment via ICOSL. | Immunology | 2026 | 42324173 | PubTator, text mining | PubMed |
| Inducible T Cell Costimulator Ligand and Inducible T Cell Costimulator Stratification Identify Dichotomous Tumor Microenvironment and Guide Chemo-Immunotherapy in Small Cell Lung Cancer. | MedComm (2020) | 2026 | 42253933 | PubTator, text mining | PubMed |
1 to 10 of 2,855
See all 2,855 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23308
GET https://conductscience.org/api/genes/v1/23308/patents?page=2