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Gene · 23327

NEDD4L: NEDD4 like E3 ubiquitin protein ligase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NEDD4L: NEDD4 like E3 ubiquitin protein ligase. Genes, record 23327. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23327

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Gene

Symbol
NEDD4L
HGNC
Name
NEDD4 like E3 ubiquitin protein ligase
HGNC
NCBI Gene ID
23327
NCBI Gene
HGNC ID
HGNC:7728
HGNC
Ensembl
ENSG00000049759
NCBI Gene
Aliases
KIAA0439, NEDD4-2, NEDD4.2, PVNH7, RSP5, hNEDD4-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96PU5E3 ubiquitin-protein ligase NEDD4-like97520Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026063204 A2026-04-105Q96PU5Espacenet
JP 2026507518 A2026-03-04151Q96PU5Espacenet
JP 2026004568 A2026-01-1455259Q96PU5Espacenet
EP 4665771 A12025-12-24151Q96PU5Espacenet
JP 2025032204 A2025-03-1132206Q96PU5Espacenet
EP 4461818 A22024-11-1332206Q96PU5Espacenet
JP 2023097901 A2023-07-106Q96PU5Espacenet
JP 2023058610 A2023-04-2532206Q96PU5Espacenet
US 11446398 B22022-09-2056028Q96PU5Espacenet
JP 2022524081 A2022-04-27158999Q96PU5Espacenet

1 to 10 of 17

See all 17 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,832

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNEDD4L papersNewest fiscal year
R01DK056695SGK Regulation of Epithelial Sodium Transport102025
P30CA016672Cancer Center Support Grant92025
P30CA008748Cancer Center Support Grant82025
P30CA013696Cancer Center Support Grant82025
R01HL121253L-type channel trafficking and modulation in heart72025
R01DA014204Regulation of Dopamine Transporter by Trafficking62025
R01DK051496WNK Kinase Regulation of Thiazide-sensitive NaCl Transport62025
R01GM058202Ubiquitin-dependent sorting in endosomes and the TGN62025
P30CA016058Cancer Center Support Grant52025
R01ES010563Mechanisms of Manganese Neurotoxicity52025

1 to 10 of 1,832Source NIH's project files

See all 1,832 nih grants

Papers2,568

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MX1 promotes gastric cancer cell migration via inhibiting ANXA2 ubiquitination and degradation.Biochim Biophys Acta Mol Basis Dis202742641668PubTator, text miningPubMed
Nav1.5 Beyond Genetics: Loss of Cardiac Sodium-Channel Function in Brugada Syndrome.Europace202642758283PubTator, text miningPubMed
Propofol alleviates OGD/R-induced cerebral ischemia-reperfusion injury-related neuronal injury by regulating NEDD4L-mediated ubiquitination of HTR2B.Biochem Biophys Res Commun202642748874PubTator, text miningPubMed
Activation of serum and glucocorticoid-induced kinase 1 promotes the release of coronavirus infectious bronchitis virus particles in cultured cells.Vet Microbiol202642743771PubTator, text miningPubMed
SGK2 Promotes NEDD4L-Mediated ACSL4 Ubiquitination to Inhibit Ferroptosis and Alleviate Diabetic Kidney Disease.Antioxid Redox Signal202642730475PubTator, text miningPubMed
Real-world pharmacogenomics-guided antihypertensive treatment response in clinical practice underrepresented population: implications for precision prescribing and medication safety.Eur J Clin Pharmacol202642722881PubTator, text miningPubMed
RIBOTAC-mediated degradation of hsa-microRNA-301a-3p suppresses TNBC bone metastasis.Sci Adv202642647607PubTator, text miningPubMed
Expanding the clinical and molecular spectrum of SETD5, NEDD4L, and TBL1X related disorders: A case report and literature review.Gene202642595145PubTator, text miningPubMed
Quercetin inhibits breast cancer progression by inducing ferroptosis via the NEDD4L-SLC7A11 axis.Gen Physiol Biophys202642583684PubTator, text miningPubMed
Nutritional and dietary drivers in the pathogenesis of acute appendicitis: the nutrition-microbiome-genetic axis.Proc Nutr Soc202642396694PubTator, text miningPubMed

1 to 10 of 2,568

See all 2,568 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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