Gene · 23327
NEDD4L: NEDD4 like E3 ubiquitin protein ligase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NEDD4L: NEDD4 like E3 ubiquitin protein ligase. Genes, record 23327. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23327
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96PU5 | E3 ubiquitin-protein ligase NEDD4-like | 975 | 20 | Ensembl, GeneID, HGNC |
Source UniProt
Patents17
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026063204 A | 2026-04-10 | 5 | Q96PU5 | Espacenet |
| JP 2026507518 A | 2026-03-04 | 151 | Q96PU5 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55259 | Q96PU5 | Espacenet |
| EP 4665771 A1 | 2025-12-24 | 151 | Q96PU5 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 32206 | Q96PU5 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 32206 | Q96PU5 | Espacenet |
| JP 2023097901 A | 2023-07-10 | 6 | Q96PU5 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 32206 | Q96PU5 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 56028 | Q96PU5 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 158999 | Q96PU5 | Espacenet |
1 to 10 of 17
See all 17 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,832
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NEDD4L papers | Newest fiscal year |
|---|---|---|---|
| R01DK056695 | SGK Regulation of Epithelial Sodium Transport | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 8 | 2025 |
| R01HL121253 | L-type channel trafficking and modulation in heart | 7 | 2025 |
| R01DA014204 | Regulation of Dopamine Transporter by Trafficking | 6 | 2025 |
| R01DK051496 | WNK Kinase Regulation of Thiazide-sensitive NaCl Transport | 6 | 2025 |
| R01GM058202 | Ubiquitin-dependent sorting in endosomes and the TGN | 6 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
| R01ES010563 | Mechanisms of Manganese Neurotoxicity | 5 | 2025 |
1 to 10 of 1,832Source NIH's project files
See all 1,832 nih grantsPapers2,568
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| MX1 promotes gastric cancer cell migration via inhibiting ANXA2 ubiquitination and degradation. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42641668 | PubTator, text mining | PubMed |
| Nav1.5 Beyond Genetics: Loss of Cardiac Sodium-Channel Function in Brugada Syndrome. | Europace | 2026 | 42758283 | PubTator, text mining | PubMed |
| Propofol alleviates OGD/R-induced cerebral ischemia-reperfusion injury-related neuronal injury by regulating NEDD4L-mediated ubiquitination of HTR2B. | Biochem Biophys Res Commun | 2026 | 42748874 | PubTator, text mining | PubMed |
| Activation of serum and glucocorticoid-induced kinase 1 promotes the release of coronavirus infectious bronchitis virus particles in cultured cells. | Vet Microbiol | 2026 | 42743771 | PubTator, text mining | PubMed |
| SGK2 Promotes NEDD4L-Mediated ACSL4 Ubiquitination to Inhibit Ferroptosis and Alleviate Diabetic Kidney Disease. | Antioxid Redox Signal | 2026 | 42730475 | PubTator, text mining | PubMed |
| Real-world pharmacogenomics-guided antihypertensive treatment response in clinical practice underrepresented population: implications for precision prescribing and medication safety. | Eur J Clin Pharmacol | 2026 | 42722881 | PubTator, text mining | PubMed |
| RIBOTAC-mediated degradation of hsa-microRNA-301a-3p suppresses TNBC bone metastasis. | Sci Adv | 2026 | 42647607 | PubTator, text mining | PubMed |
| Expanding the clinical and molecular spectrum of SETD5, NEDD4L, and TBL1X related disorders: A case report and literature review. | Gene | 2026 | 42595145 | PubTator, text mining | PubMed |
| Quercetin inhibits breast cancer progression by inducing ferroptosis via the NEDD4L-SLC7A11 axis. | Gen Physiol Biophys | 2026 | 42583684 | PubTator, text mining | PubMed |
| Nutritional and dietary drivers in the pathogenesis of acute appendicitis: the nutrition-microbiome-genetic axis. | Proc Nutr Soc | 2026 | 42396694 | PubTator, text mining | PubMed |
1 to 10 of 2,568
See all 2,568 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23327
GET https://conductscience.org/api/genes/v1/23327/patents