Gene · 23345
SYNE1: spectrin repeat containing nuclear envelope protein 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SYNE1: spectrin repeat containing nuclear envelope protein 1. Genes, record 23345. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23345
On this page
Gene
- Aliases
- 8B, AMC3, AMCM, ARCA1, C6orf98, CPG2, EDMD4, KASH1, KIAA0796, MYNE1, Nesp1, Nesprin-1, SCAR8, SYNE-1B, dJ45H2.2, enaptin
- NCBI Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8NF91 | Nesprin-1 | 8,797 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65078 | Q8NF91 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8357 | Q8NF91 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 451 | Q8NF91 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4538 | Q8NF91 | Espacenet |
| JP 2025128208 A | 2025-09-02 | 22 | Q8NF91 | Espacenet |
| JP 2025111747 A | 2025-07-30 | 134 | Q8NF91 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4538 | Q8NF91 | Espacenet |
| JP 2025102886 A | 2025-07-08 | 102 | Q8NF91 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8357 | Q8NF91 | Espacenet |
| WO 2025040788 A1 | 2025-02-27 | 31 | Q8NF91 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,489
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SYNE1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 6 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 4 | 2025 |
| P30CA118100 | University of New Mexico Cancer Center Support Grant | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,489Source NIH's project files
See all 1,489 nih grantsPapers2,274
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Fine-tuning a compact large language model on real-world cases yields diagnostic performance comparable to flagship models in rheumatology. | Int J Med Inform | 2026 | 42763976 | PubTator, text mining | PubMed |
| Analysis of single nucleotide polymorphism of SYNE1 gene in Oral squamous cell carcinoma. | J Cancer | 2026 | 42741643 | PubTator, text mining | PubMed |
| The role of SYNE1/2 variants as a potential predisposition factor for the onset of endometriosis. | Front Immunol | 2026 | 42712468 | PubTator, text mining | PubMed |
| Integrating clinical and genomic features to predict response to neoadjuvant therapy in microsatellite-stable rectal cancer. | Ther Adv Med Oncol | 2026 | 42682925 | PubTator, text mining | PubMed |
| Whole-exome sequencing in individuals with obsessive-compulsive disorder and chronic tic disorders identifies 36 large-effect risk genes. | Nat Neurosci | 2026 | 42680906 | PubTator, text mining | PubMed |
| Endothelial miR-15a/16-1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury. | Adv Sci (Weinh) | 2026 | 42584458 | PubTator, text mining | PubMed |
| Lessons from a systematic review of family-based studies in ALS. | Amyotroph Lateral Scler Frontotemporal Degener | 2026 | 42584174 | PubTator, text mining | PubMed |
| Unveiling the power of TIIC: A prognostic tool for esophageal adenocarcinoma. | Transl Oncol | 2026 | 42556130 | PubTator, text mining | PubMed |
| Shared Genetic Architecture and Pleiotropic Loci Linking Endometriosis and Inflammatory Bowel Disease: An Integrative GWAS, Colocalization, and Mendelian Randomization Study. | Biomed Res Int | 2026 | 42515984 | PubTator, text mining | PubMed |
| Exome Sequencing uncovers Homozygous Stop-Gained variant in the SYNE1 Gene Leading to Spinocerebellar Ataxia. | Pak J Med Sci | 2026 | 42487839 | PubTator, text mining | PubMed |
1 to 10 of 2,274
See all 2,274 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23345
GET https://conductscience.org/api/genes/v1/23345/patents?page=2