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Gene · 23345

SYNE1: spectrin repeat containing nuclear envelope protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SYNE1: spectrin repeat containing nuclear envelope protein 1. Genes, record 23345. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23345

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Gene

Symbol
SYNE1
HGNC
Name
spectrin repeat containing nuclear envelope protein 1
HGNC
NCBI Gene ID
23345
NCBI Gene
HGNC ID
HGNC:17089
HGNC
Ensembl
ENSG00000131018
NCBI Gene
Aliases
8B, AMC3, AMCM, ARCA1, C6orf98, CPG2, EDMD4, KASH1, KIAA0796, MYNE1, Nesp1, Nesprin-1, SCAR8, SYNE-1B, dJ45H2.2, enaptin
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8NF91Nesprin-18,7973Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465078Q8NF91Espacenet
EP 4641201 A22025-10-298357Q8NF91Espacenet
EP 4641202 A22025-10-29451Q8NF91Espacenet
JP 2025529142 A2025-09-044538Q8NF91Espacenet
JP 2025128208 A2025-09-0222Q8NF91Espacenet
JP 2025111747 A2025-07-30134Q8NF91Espacenet
US 12371689 B22025-07-294538Q8NF91Espacenet
JP 2025102886 A2025-07-08102Q8NF91Espacenet
JP 2025517969 A2025-06-128357Q8NF91Espacenet
WO 2025040788 A12025-02-2731Q8NF91Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,489

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSYNE1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA015704Cancer Center Support Grant62025
P30CA076292Moffitt Cancer Center Support Grant52025
P30CA008748Cancer Center Support Grant42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA118100University of New Mexico Cancer Center Support Grant42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
P30CA016086Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025

1 to 10 of 1,489Source NIH's project files

See all 1,489 nih grants

Papers2,274

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Fine-tuning a compact large language model on real-world cases yields diagnostic performance comparable to flagship models in rheumatology.Int J Med Inform202642763976PubTator, text miningPubMed
Analysis of single nucleotide polymorphism of SYNE1 gene in Oral squamous cell carcinoma.J Cancer202642741643PubTator, text miningPubMed
The role of SYNE1/2 variants as a potential predisposition factor for the onset of endometriosis.Front Immunol202642712468PubTator, text miningPubMed
Integrating clinical and genomic features to predict response to neoadjuvant therapy in microsatellite-stable rectal cancer.Ther Adv Med Oncol202642682925PubTator, text miningPubMed
Whole-exome sequencing in individuals with obsessive-compulsive disorder and chronic tic disorders identifies 36 large-effect risk genes.Nat Neurosci202642680906PubTator, text miningPubMed
Endothelial miR-15a/16-1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury.Adv Sci (Weinh)202642584458PubTator, text miningPubMed
Lessons from a systematic review of family-based studies in ALS.Amyotroph Lateral Scler Frontotemporal Degener202642584174PubTator, text miningPubMed
Unveiling the power of TIIC: A prognostic tool for esophageal adenocarcinoma.Transl Oncol202642556130PubTator, text miningPubMed
Shared Genetic Architecture and Pleiotropic Loci Linking Endometriosis and Inflammatory Bowel Disease: An Integrative GWAS, Colocalization, and Mendelian Randomization Study.Biomed Res Int202642515984PubTator, text miningPubMed
Exome Sequencing uncovers Homozygous Stop-Gained variant in the SYNE1 Gene Leading to Spinocerebellar Ataxia.Pak J Med Sci202642487839PubTator, text miningPubMed

1 to 10 of 2,274

See all 2,274 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23345

GET https://conductscience.org/api/genes/v1/23345/patents?page=2