Gene · 23385
NCSTN: nicastrin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NCSTN: nicastrin. Genes, record 23385. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23385
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92542 | Nicastrin | 709 | 30 | Ensembl, GeneID, HGNC |
Source UniProt
Patents228
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 55670 | Q92542 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3578 | Q92542 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 9217 | Q92542 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2792 | Q92542 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7120 | Q92542 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2792 | Q92542 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7120 | Q92542 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3578 | Q92542 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 9217 | Q92542 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 9217 | Q92542 | Espacenet |
1 to 10 of 228
See all 228 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AVAGACESTAT | CHEMBL1090771 | Gamma-secretase inhibitor | INHIBITOR | ChEMBL |
| BEGACESTAT | CHEMBL463981 | Gamma-secretase inhibitor | INHIBITOR | ChEMBL |
| NIROGACESTAT | CHEMBL1770916 | Gamma-secretase inhibitor | INHIBITOR | ChEMBL |
| NIROGACESTAT HYDROBROMIDE | CHEMBL4298153 | Gamma-secretase inhibitor | INHIBITOR | ChEMBL |
| RG-4733 | CHEMBL4297422 | Gamma-secretase inhibitor | INHIBITOR | ChEMBL |
| SEMAGACESTAT | CHEMBL520733 | Gamma-secretase inhibitor | INHIBITOR | ChEMBL |
| TARENFLURBIL | CHEMBL190083 | Gamma-secretase modulator | MODULATOR | ChEMBL |
Trials67
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07539454 | NIROGACESTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07176689 | NIROGACESTAT | PHASE4 | ClinicalTrials.gov | |
| NCT07170644 | NIROGACESTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07150104 | NIROGACESTAT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07150091 | NIROGACESTAT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07084896 | NIROGACESTAT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05949099 | NIROGACESTAT | PHASE2 | ClinicalTrials.gov | |
| NCT05879146 | NIROGACESTAT | PHASE2 | ClinicalTrials.gov | |
| NCT05573802 | NIROGACESTAT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05556798 | NIROGACESTAT | PHASE1 | ClinicalTrials.gov |
1 to 10 of 67
See all 67 trialsNIH grants1,282
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NCSTN papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA168524 | The University of Kansas Cancer Center | 5 | 2025 |
| ZIAAG000311 | ALZHEIMERS RESEARCH PROJECT: Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease) | 4 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 3 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 3 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 3 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 3 | 2025 |
| P50CA058223 | SPORE in Breast Cancer | 3 | 2025 |
1 to 10 of 1,282Source NIH's project files
See all 1,282 nih grantsPapers1,830
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Use of an Intramolecular Quenched Fluorescence (IQF) Cleavage Assay for Assessing Enzyme Kinetics of Gamma-Secretase in Human Skin Fibroblasts and Keratinocytes. | Methods Mol Biol | 2027 | 39776075 | PubTator, text mining | PubMed |
| Targeting mannosylation of nicastrin N-glycans attenuates γ-secretase activity and notch-dependent leukemia progression. | J Clin Invest | 2026 | 42820286 | PubTator, text mining | PubMed |
| Nicastrin Regulates Cutaneous Squamous Cell Carcinoma Progression Through the MAPK/ERK Signalling. | Exp Dermatol | 2026 | 42712002 | PubTator, text mining | PubMed |
| The role of Notch signalling and its crosstalk with oestrogen receptor signalling in breast cancer. | Cancer Metastasis Rev | 2026 | 41894035 | PubTator, text mining | PubMed |
| 5-Hydroxymethylcytosine profiles in circulating cell-free DNA serve as potential biomarkers for diagnosis and classification of adenomyosis. | EBioMedicine | 2026 | 41861514 | PubTator, text mining | PubMed |
| TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins. | Autophagy Rep | 2026 | 41799849 | PubTator, text mining | PubMed |
| Distinct Regulatory Genomic Architectures Distinguish Early-Onset from Late-Onset Alzheimer's Disease. | Genes (Basel) | 2026 | 41751570 | PubTator, text mining | PubMed |
| Exploring Gene Expression Patterns in Alzheimer's Disease Using a Human Microarray Data Meta-Analysis. | Biology (Basel) | 2026 | 41744654 | PubTator, text mining | PubMed |
| Evidence that extra copies of chromosome 1q play a role in the early phases of pancreatic neoplasia. | Sci Adv | 2026 | 41719404 | PubTator, text mining | PubMed |
| Amyloid Beta Oligomers as Early Triggers of Neuronal Cytoskeleton Dysfunction in Alzheimer's Disease. | Pathophysiology | 2026 | 41718392 | PubTator, text mining | PubMed |
1 to 10 of 1,830
See all 1,830 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23385
GET https://conductscience.org/api/genes/v1/23385/patents?page=2