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SIRT5: sirtuin 5
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Gene · 23408

Papers2,327

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,327

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TitleJournalYearPMIDFound bySource
AARS2-SIRT5-Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells.Adv Sci (Weinh)202642806865PubTator, text miningPubMed
SIRT5-Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate-Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis.Adv Sci (Weinh)202642801594PubTator, text miningPubMed
SphK1 membrane targeting acts on PKM2 succinylation to fuel synovial hyperplasia in rheumatoid arthritis.Int Immunopharmacol202642800384PubTator, text miningPubMed
Cancer Stem Cell Quiescence: Molecular and Microenvironmental Evidence for an Actively Regulated Adaptive Survival Strategy.Cancer Med202642768738PubTator, text miningPubMed
The expression and clinical significance of SIRT5, H2A and TOP2A in cervical cancer.Front Oncol202642755804PubTator, text miningPubMed
Experimental approaches for investigating sirtuin-mediated mitochondrial function, cellular metabolism, and epigenetic regulation.Methods Enzymol202642692759PubTator, text miningPubMed
Novel Insights into the Pleiotropic Neuroprotective Action of Synthetic Halogen Free Thyronamine-like Analogues.Molecules202642653915PubTator, text miningPubMed
Research progress on metabolic abnormalities in myocardial hypertrophy.Front Cardiovasc Med202642602298PubTator, text miningPubMed
Comparative Structure-Based Analysis of Predicted BZD9L1 Binding Modes Across Human Sirtuins.Int J Mol Sci202642589496PubTator, text miningPubMed
Beyond acetylation: Evaluating the emerging biology of lysine acylation.Cell Chem Biol202642586062PubTator, text miningPubMed
Protective mechanisms of Sirtuin Family in myocardial ischemia-reperfusion injury and translational therapeutic perspectives.Mol Biol Rep202642584557PubTator, text miningPubMed
RETRACTION: SIRT5-Related Desuccinylation Modification Contributes to Quercetin-Induced Protection against Heart Failure and High Glucose-Prompted Cardiomyocytes Injured through Regulation of Mitochondrial Quality Surveillance.
Oxid Med Cell Longev202642559745PubTator, text miningPubMed
Sirtuin five knockdown induced the ferroptosis of hepatic stellate cells in hepatic fibrosis progression through de-succinylation modification of GPX4.J Biol Chem202642497991PubTator, text miningPubMed
SIRT Family: Biological Functions and Therapeutic Targets.MedComm (2020)202642488706PubTator, text miningPubMed
The SIRT5-SUCLG2 desuccinylation axis delays ovarian aging via a mitochondrial-epigenetic regulatory mechanism.Nat Commun202642457680PubTator, text miningPubMed
SIRT5/7 desuccinylation in cancer: linking metabolism, immunity, and drug resistance.Biochem Pharmacol202642456824PubTator, text miningPubMed
The Sirtuin Network: Linking NAD+ Metabolism, Mitochondrial Function, and Metabolic Homoeostasis.Diabetes Metab Res Rev202642442718PubTator, text miningPubMed
SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function.bioRxiv202642427712PubTator, text miningPubMed
Carvacrol-Based Formulations Modulate Sirtuins and Exert Cytotoxic and Antimicrobial Effects in Lung Cancer Models.Antioxidants (Basel)202642352025PubTator, text miningPubMed
SIRT5 mediates the pro-osteogenic effects of estrogen through FDX1 demalonylation and cuproptosis inhibition in mesenchymal stem cells.Genes Dis202642290657PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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