Gene · 23408
SIRT5: sirtuin 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SIRT5: sirtuin 5. Genes, record 23408. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23408
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NXA8 | NAD-dependent protein deacylase sirtuin-5, mitochondrial | 310 | 27 | Ensembl, GeneID, HGNC |
Source UniProt
Patents38
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63669 | Q9NXA8 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 18184 | Q9NXA8 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 18184 | Q9NXA8 | Espacenet |
| EP 4491229 A2 | 2025-01-15 | 277 | Q9NXA8 | Espacenet |
| WO 2024230934 A1 | 2024-11-14 | 402 | Q9NXA8 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 79444 | Q9NXA8 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 182415 | Q9NXA8 | Espacenet |
| WO 2021225781 A2 | 2021-11-11 | 2 | Q9NXA8 | Espacenet |
| US 11110107 B2 | 2021-09-07 | 2 | Q9NXA8 | Espacenet |
| WO 2020161342 A1 | 2020-08-13 | 277 | Q9NXA8 | Espacenet |
1 to 10 of 38
See all 38 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,222
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SIRT5 papers | Newest fiscal year |
|---|---|---|---|
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 9 | 2025 |
| T32AG000114 | Career Training in the Biology of Aging | 8 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 7 | 2025 |
| P30DK026743 | UCSF Liver Center | 7 | 2025 |
| P30AG028716 | Duke Claude D. Pepper Older Americans Independence Center | 6 | 2025 |
| R01AR078555 | Histone lactylation pathway in hair cycle: deacylases and their protein targets | 6 | 2025 |
| T32AG000266 | Training in Basic Research on Aging and Age-Related Disease | 6 | 2025 |
| ZIAHL005102 | Metabolic pathways linked to immunity | 6 | 2025 |
| P20GM103449 | Vermont Biomedical Research Network-Vermont INBRE | 5 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 4 | 2025 |
1 to 10 of 1,222Source NIH's project files
See all 1,222 nih grantsPapers2,327
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| AARS2-SIRT5-Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells. | Adv Sci (Weinh) | 2026 | 42806865 | PubTator, text mining | PubMed |
| SIRT5-Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate-Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis. | Adv Sci (Weinh) | 2026 | 42801594 | PubTator, text mining | PubMed |
| SphK1 membrane targeting acts on PKM2 succinylation to fuel synovial hyperplasia in rheumatoid arthritis. | Int Immunopharmacol | 2026 | 42800384 | PubTator, text mining | PubMed |
| Cancer Stem Cell Quiescence: Molecular and Microenvironmental Evidence for an Actively Regulated Adaptive Survival Strategy. | Cancer Med | 2026 | 42768738 | PubTator, text mining | PubMed |
| The expression and clinical significance of SIRT5, H2A and TOP2A in cervical cancer. | Front Oncol | 2026 | 42755804 | PubTator, text mining | PubMed |
| Experimental approaches for investigating sirtuin-mediated mitochondrial function, cellular metabolism, and epigenetic regulation. | Methods Enzymol | 2026 | 42692759 | PubTator, text mining | PubMed |
| Novel Insights into the Pleiotropic Neuroprotective Action of Synthetic Halogen Free Thyronamine-like Analogues. | Molecules | 2026 | 42653915 | PubTator, text mining | PubMed |
| Research progress on metabolic abnormalities in myocardial hypertrophy. | Front Cardiovasc Med | 2026 | 42602298 | PubTator, text mining | PubMed |
| Comparative Structure-Based Analysis of Predicted BZD9L1 Binding Modes Across Human Sirtuins. | Int J Mol Sci | 2026 | 42589496 | PubTator, text mining | PubMed |
| Beyond acetylation: Evaluating the emerging biology of lysine acylation. | Cell Chem Biol | 2026 | 42586062 | PubTator, text mining | PubMed |
1 to 10 of 2,327
See all 2,327 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23408
GET https://conductscience.org/api/genes/v1/23408/patents?page=2