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Gene · 23408

SIRT5: sirtuin 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SIRT5: sirtuin 5. Genes, record 23408. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23408

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Gene

Symbol
SIRT5
HGNC
Name
sirtuin 5
HGNC
NCBI Gene ID
23408
NCBI Gene
HGNC ID
HGNC:14933
HGNC
Ensembl
ENSG00000124523
NCBI Gene
Aliases
SIR2L5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NXA8NAD-dependent protein deacylase sirtuin-5, mitochondrial31027Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463669Q9NXA8Espacenet
EP 4650780 A22025-11-1918184Q9NXA8Espacenet
JP 2025517970 A2025-06-1218184Q9NXA8Espacenet
EP 4491229 A22025-01-15277Q9NXA8Espacenet
WO 2024230934 A12024-11-14402Q9NXA8Espacenet
US 11446398 B22022-09-2079444Q9NXA8Espacenet
JP 2022524081 A2022-04-27182415Q9NXA8Espacenet
WO 2021225781 A22021-11-112Q9NXA8Espacenet
US 11110107 B22021-09-072Q9NXA8Espacenet
WO 2020161342 A12020-08-13277Q9NXA8Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,222

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSIRT5 papersNewest fiscal year
P30DK020572Michigan Diabetes Research Center (MDRC)92025
T32AG000114Career Training in the Biology of Aging82025
P30AI027763UCSF-Bay Area Center for AIDS Research72025
P30DK026743UCSF Liver Center72025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center62025
R01AR078555Histone lactylation pathway in hair cycle: deacylases and their protein targets62025
T32AG000266Training in Basic Research on Aging and Age-Related Disease62025
ZIAHL005102Metabolic pathways linked to immunity62025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE52025
P30AG028740University of Florida Older Americans Independence Center (OAIC)42025

1 to 10 of 1,222Source NIH's project files

See all 1,222 nih grants

Papers2,327

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
AARS2-SIRT5-Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells.Adv Sci (Weinh)202642806865PubTator, text miningPubMed
SIRT5-Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate-Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis.Adv Sci (Weinh)202642801594PubTator, text miningPubMed
SphK1 membrane targeting acts on PKM2 succinylation to fuel synovial hyperplasia in rheumatoid arthritis.Int Immunopharmacol202642800384PubTator, text miningPubMed
Cancer Stem Cell Quiescence: Molecular and Microenvironmental Evidence for an Actively Regulated Adaptive Survival Strategy.Cancer Med202642768738PubTator, text miningPubMed
The expression and clinical significance of SIRT5, H2A and TOP2A in cervical cancer.Front Oncol202642755804PubTator, text miningPubMed
Experimental approaches for investigating sirtuin-mediated mitochondrial function, cellular metabolism, and epigenetic regulation.Methods Enzymol202642692759PubTator, text miningPubMed
Novel Insights into the Pleiotropic Neuroprotective Action of Synthetic Halogen Free Thyronamine-like Analogues.Molecules202642653915PubTator, text miningPubMed
Research progress on metabolic abnormalities in myocardial hypertrophy.Front Cardiovasc Med202642602298PubTator, text miningPubMed
Comparative Structure-Based Analysis of Predicted BZD9L1 Binding Modes Across Human Sirtuins.Int J Mol Sci202642589496PubTator, text miningPubMed
Beyond acetylation: Evaluating the emerging biology of lysine acylation.Cell Chem Biol202642586062PubTator, text miningPubMed

1 to 10 of 2,327

See all 2,327 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23408

GET https://conductscience.org/api/genes/v1/23408/patents?page=2