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Gene · 23409

SIRT4: sirtuin 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SIRT4: sirtuin 4. Genes, record 23409. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23409

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Gene

Symbol
SIRT4
HGNC
Name
sirtuin 4
HGNC
NCBI Gene ID
23409
NCBI Gene
HGNC ID
HGNC:14932
HGNC
Ensembl
ENSG00000089163
NCBI Gene
Aliases
SIR2L4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y6E7NAD-dependent protein lipoamidase sirtuin-4, mitochondrial3140Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463667Q9Y6E7Espacenet
EP 4491229 A22025-01-15276Q9Y6E7Espacenet
WO 2024230934 A12024-11-14401Q9Y6E7Espacenet
US 11726088 B22023-08-152Q9Y6E7Espacenet
US 11446398 B22022-09-2079437Q9Y6E7Espacenet
JP 2022524081 A2022-04-27182408Q9Y6E7Espacenet
US 11078247 B22021-08-0310296Q9Y6E7Espacenet
US 10788492 B22020-09-292Q9Y6E7Espacenet
WO 2020161342 A12020-08-13276Q9Y6E7Espacenet
JP 2019054813 A2019-04-11244102Q9Y6E7Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants875

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSIRT4 papersNewest fiscal year
P30AI027763UCSF-Bay Area Center for AIDS Research52025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
ZIAHL005102Metabolic pathways linked to immunity52025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center42025
P30DK026743UCSF Liver Center42025
R01HL091469Cysteine oxidation in the heart42025
T32AG000114Career Training in the Biology of Aging42025
ZIAES102205Sirtuins and nuclear receptors in aging and age-associated diseases42025
P30CA008748Cancer Center Support Grant32025
P30CA033572Cancer Center Support Grant32025

1 to 10 of 875Source NIH's project files

See all 875 nih grants

Papers1,901

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Correlation analysis of serum SIRT4, CTRP5, and galectin-3 levels with the prognosis of diabetic retinopathy patients.J Med Biochem202642781214PubTator, text miningPubMed
KRT19 promotes colorectal cancer progression through mTOR pathway via SIRT4.Gen Physiol Biophys202642717787PubTator, text miningPubMed
Experimental approaches for investigating sirtuin-mediated mitochondrial function, cellular metabolism, and epigenetic regulation.Methods Enzymol202642692759PubTator, text miningPubMed
Sirtuins in mitochondrial physiology and energy homeostasis.Methods Enzymol202642624555PubTator, text miningPubMed
Beyond acetylation: Evaluating the emerging biology of lysine acylation.Cell Chem Biol202642586062PubTator, text miningPubMed
Protective mechanisms of Sirtuin Family in myocardial ischemia-reperfusion injury and translational therapeutic perspectives.Mol Biol Rep202642584557PubTator, text miningPubMed
SIRT Family: Biological Functions and Therapeutic Targets.MedComm (2020)202642488706PubTator, text miningPubMed
Correction: Transcription factor CEBPA suppresses sepsis induced lung injury by activating SIRT4 transcription.Sci Rep202642487044PubTator, text miningPubMed
Targeting Sirtuins in Thyroid Cancer: Mechanisms, Drug Development, and Emerging Roles in Tumor Immunity and Ferroptosis.Cancers (Basel)202642449637PubTator, text miningPubMed
The Sirtuin Network: Linking NAD+ Metabolism, Mitochondrial Function, and Metabolic Homoeostasis.Diabetes Metab Res Rev202642442718PubTator, text miningPubMed

1 to 10 of 1,901

See all 1,901 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23409

GET https://conductscience.org/api/genes/v1/23409/patents?page=2