Gene · 23409
SIRT4: sirtuin 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SIRT4: sirtuin 4. Genes, record 23409. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23409
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y6E7 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial | 314 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents39
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63667 | Q9Y6E7 | Espacenet |
| EP 4491229 A2 | 2025-01-15 | 276 | Q9Y6E7 | Espacenet |
| WO 2024230934 A1 | 2024-11-14 | 401 | Q9Y6E7 | Espacenet |
| US 11726088 B2 | 2023-08-15 | 2 | Q9Y6E7 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 79437 | Q9Y6E7 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 182408 | Q9Y6E7 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 10296 | Q9Y6E7 | Espacenet |
| US 10788492 B2 | 2020-09-29 | 2 | Q9Y6E7 | Espacenet |
| WO 2020161342 A1 | 2020-08-13 | 276 | Q9Y6E7 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 244102 | Q9Y6E7 | Espacenet |
1 to 10 of 39
See all 39 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants875
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SIRT4 papers | Newest fiscal year |
|---|---|---|---|
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 5 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| ZIAHL005102 | Metabolic pathways linked to immunity | 5 | 2025 |
| P30AG028716 | Duke Claude D. Pepper Older Americans Independence Center | 4 | 2025 |
| P30DK026743 | UCSF Liver Center | 4 | 2025 |
| R01HL091469 | Cysteine oxidation in the heart | 4 | 2025 |
| T32AG000114 | Career Training in the Biology of Aging | 4 | 2025 |
| ZIAES102205 | Sirtuins and nuclear receptors in aging and age-associated diseases | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 875Source NIH's project files
See all 875 nih grantsPapers1,901
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Correlation analysis of serum SIRT4, CTRP5, and galectin-3 levels with the prognosis of diabetic retinopathy patients. | J Med Biochem | 2026 | 42781214 | PubTator, text mining | PubMed |
| KRT19 promotes colorectal cancer progression through mTOR pathway via SIRT4. | Gen Physiol Biophys | 2026 | 42717787 | PubTator, text mining | PubMed |
| Experimental approaches for investigating sirtuin-mediated mitochondrial function, cellular metabolism, and epigenetic regulation. | Methods Enzymol | 2026 | 42692759 | PubTator, text mining | PubMed |
| Sirtuins in mitochondrial physiology and energy homeostasis. | Methods Enzymol | 2026 | 42624555 | PubTator, text mining | PubMed |
| Beyond acetylation: Evaluating the emerging biology of lysine acylation. | Cell Chem Biol | 2026 | 42586062 | PubTator, text mining | PubMed |
| Protective mechanisms of Sirtuin Family in myocardial ischemia-reperfusion injury and translational therapeutic perspectives. | Mol Biol Rep | 2026 | 42584557 | PubTator, text mining | PubMed |
| SIRT Family: Biological Functions and Therapeutic Targets. | MedComm (2020) | 2026 | 42488706 | PubTator, text mining | PubMed |
| Correction: Transcription factor CEBPA suppresses sepsis induced lung injury by activating SIRT4 transcription. | Sci Rep | 2026 | 42487044 | PubTator, text mining | PubMed |
| Targeting Sirtuins in Thyroid Cancer: Mechanisms, Drug Development, and Emerging Roles in Tumor Immunity and Ferroptosis. | Cancers (Basel) | 2026 | 42449637 | PubTator, text mining | PubMed |
| The Sirtuin Network: Linking NAD+ Metabolism, Mitochondrial Function, and Metabolic Homoeostasis. | Diabetes Metab Res Rev | 2026 | 42442718 | PubTator, text mining | PubMed |
1 to 10 of 1,901
See all 1,901 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23409
GET https://conductscience.org/api/genes/v1/23409/patents?page=2