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SIRT3: sirtuin 3

1 protein, 33 patents, 0 drugs, 0 trials, 2,870 NIH grants and 7,130 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSIRT3HGNC
Namesirtuin 3HGNC
NCBI Gene ID23410NCBI Gene
HGNC IDHGNC:14931HGNC
EnsemblENSG00000142082NCBI Gene
AliasesSIR2L3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9NTG7NAD-dependent protein deacetylase sirtuin-3, mitochondrial39944Ensembl, GeneID, HGNCUniProt

Patents 33

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463664Q9NTG7Espacenet
WO 2025181335 A12025-09-0416Q9NTG7Espacenet
EP 4491229 A22025-01-15268Q9NTG7Espacenet
WO 2024230934 A12024-11-14393Q9NTG7Espacenet
US 11446398 B22022-09-2079424Q9NTG7Espacenet
JP 2022524081 A2022-04-27182395Q9NTG7Espacenet
WO 2020161342 A12020-08-13268Q9NTG7Espacenet
JP 2019054813 A2019-04-11244099Q9NTG7Espacenet
JP 2017121241 A2017-07-13244099Q9NTG7Espacenet
US 9597347 B22017-03-218Q9NTG7Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2870

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA060553The Robert H. Lurie Comprehensive Cancer Center142,025NIH's project files
ZIAHL006047Role of intracellular organelle homeostasis in adaptation to dietary restrictive interventions142,025NIH's project files
ZIAHL005102Metabolic pathways linked to immunity122,025NIH's project files
P30DK026743UCSF Liver Center112,025NIH's project files
P30AG028740University of Florida Older Americans Independence Center (OAIC)102,025NIH's project files
P30CA086862Cancer Center Support Grant102,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research92,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)92,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support82,025NIH's project files
P30DK048520Colorado Nutrition Obesity Research Center82,025NIH's project files

Papers 7130

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827417PubTator, text miningPubMed
42826841PubTator, text miningPubMed
42822579PubTator, text miningPubMed
42814283PubTator, text miningPubMed
42809895PubTator, text miningPubMed
42807349PubTator, text miningPubMed
42801737PubTator, text miningPubMed
42801604PubTator, text miningPubMed
42795268PubTator, text miningPubMed
42780667PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license