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SIRT1: sirtuin 1

1 protein, 140 patents, 2 drugs, 4 trials, 10,025 NIH grants and 34,814 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSIRT1HGNC
Namesirtuin 1HGNC
NCBI Gene ID23411NCBI Gene
HGNC IDHGNC:14929HGNC
EnsemblENSG00000096717NCBI Gene
AliasesSIR2, SIR2L1, SIR2alphaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q96EB6NAD-dependent protein deacetylase sirtuin-17479Ensembl, GeneID, HGNCUniProt

Patents 140

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19256Q96EB6Espacenet
JP 2025169942 A2025-11-141279Q96EB6Espacenet
EP 4641201 A22025-10-29219Q96EB6Espacenet
JP 2025517969 A2025-06-12219Q96EB6Espacenet
JP 2025517970 A2025-06-12256Q96EB6Espacenet
EP 4541897 A22025-04-2317Q96EB6Espacenet
EP 4491229 A22025-01-15257Q96EB6Espacenet
WO 2024230934 A12024-11-14382Q96EB6Espacenet
US 12116592 B22024-10-152Q96EB6Espacenet
JP 2024112982 A2024-08-214573Q96EB6Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EX-527CHEMBL382277NAD-dependent deacetylase sirtuin 1 inhibitorINHIBITORChEMBL
SRT-2104CHEMBL4297436NAD-dependent deacetylase sirtuin 1 activatorACTIVATORChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01453491SRT-2104PHASE1ClinicalTrials.gov
NCT01031108SRT-2104PHASE1ClinicalTrials.gov
NCT01018017SRT-2104PHASE2ClinicalTrials.gov
NCT00937326SRT-2104PHASE22018-04-09ClinicalTrials.gov

NIH grants 10025

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant552,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)352,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center352,025NIH's project files
ZIAES102205Sirtuins and nuclear receptors in aging and age-associated diseases322,025NIH's project files
P30ES001247Environmental Agents as Modulators of Disease Processes302,025NIH's project files
P30CA008748Cancer Center Support Grant272,025NIH's project files
ZIAAG000363Aging Intervention Program262,025NIH's project files
P30AG028740University of Florida Older Americans Independence Center (OAIC)252,025NIH's project files
P30DK072476Pennington/Louisiana NORC252,025NIH's project files
ZIAAG000393Influence of Post-transcriptional Gene Regulation on Cell Senescence and Aging232,025NIH's project files

Papers 34814

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821781PubTator, text miningPubMed
42821770PubTator, text miningPubMed
42821470PubTator, text miningPubMed
42821192PubTator, text miningPubMed
42817107PubTator, text miningPubMed
42816692PubTator, text miningPubMed
42815331PubTator, text miningPubMed
42813623PubTator, text miningPubMed
42813448PubTator, text miningPubMed
42811505PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license