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FOLH1: folate hydrolase 1

1 protein, 480 patents, 9 drugs, 116 trials, 3,361 NIH grants and 13,509 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFOLH1HGNC
Namefolate hydrolase 1HGNC
NCBI Gene ID2346NCBI Gene
HGNC IDHGNC:3788HGNC
EnsemblENSG00000086205NCBI Gene
AliasesFGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q04609Glutamate carboxypeptidase 275088Ensembl, GeneID, HGNCUniProt

Patents 480

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026219966 A12026-10-2257Q04609Espacenet
EP 4825875 A12026-10-2157Q04609Espacenet
WO 2026213276 A12026-10-0821Q04609Espacenet
WO 2026180468 A12026-09-0329Q04609Espacenet
EP 4755403 A12026-06-101Q04609Espacenet
EP 4750803 A12026-06-033Q04609Espacenet
JP 2026514046 A2026-05-011Q04609Espacenet
JP 2026508181 A2026-03-1067Q04609Espacenet
JP 2026507228 A2026-02-272Q04609Espacenet
EP 4694941 A12026-02-181Q04609Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CYT-500 177LUCHEMBL2109553Glutamate carboxypeptidase II binding agentBINDING AGENTChEMBL
HUJ591 111INCHEMBL2109677Glutamate carboxypeptidase II binding agentBINDING AGENTChEMBL
HUJ591 177LUCHEMBL2109678Glutamate carboxypeptidase II binding agentBINDING AGENTChEMBL
J591 177LUCHEMBL2109559Glutamate carboxypeptidase II binding agentBINDING AGENTChEMBL
LUTETIUM LU-177 VIPIVOTIDE TETRAXETANCHEMBL4594406Glutamate carboxypeptidase II binding agentBINDING AGENTChEMBL
MDX-070CHEMBL2109555Glutamate carboxypeptidase II otherOTHERChEMBL
MLN-2704CHEMBL2109556Glutamate carboxypeptidase II binding agentBINDING AGENTChEMBL
VIPIVOTIDE TETRAXETAN LUTETIUMCHEMBL4594730Glutamate carboxypeptidase II binding agentBINDING AGENTChEMBL
YTTRIUM Y 90 CAPROMAB PENDETIDECHEMBL2109552Glutamate carboxypeptidase II binding agentBINDING AGENTChEMBL

Trials 116

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07562438LUTETIUM LU-177 VIPIVOTIDE TETRAXETANPHASE2ClinicalTrials.gov
NCT07550517LUTETIUM LU-177 VIPIVOTIDE TETRAXETANPHASE2ClinicalTrials.gov
NCT07542379LUTETIUM LU-177 VIPIVOTIDE TETRAXETANEARLY_PHASE1ClinicalTrials.gov
NCT07537010LUTETIUM LU-177 VIPIVOTIDE TETRAXETANPHASE1ClinicalTrials.gov
NCT07316686LUTETIUM LU-177 VIPIVOTIDE TETRAXETANPHASE1ClinicalTrials.gov
NCT07229768LUTETIUM LU-177 VIPIVOTIDE TETRAXETANEARLY_PHASE1ClinicalTrials.gov
NCT07223034LUTETIUM LU-177 VIPIVOTIDE TETRAXETANPHASE1ClinicalTrials.gov
NCT07219147LUTETIUM LU-177 VIPIVOTIDE TETRAXETANPHASE1ClinicalTrials.gov
NCT07189871LUTETIUM LU-177 VIPIVOTIDE TETRAXETANPHASE1/PHASE2ClinicalTrials.gov
NCT07185672LUTETIUM LU-177 VIPIVOTIDE TETRAXETANPHASE3ClinicalTrials.gov

NIH grants 3361

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2162,025NIH's project files
R01CA134675Enhanced imaging and treatment of aggressive subtypes of prostate cancer1032,025NIH's project files
P30CA006973Regional Oncology Research Center772,025NIH's project files
ZIABC010655Prostate Cancer Imaging492,025NIH's project files
P30CA016042Cancer Center Support Grant382,025NIH's project files
P50CA097186The Pacific Northwest Prostate Cancer SPORE382,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support322,025NIH's project files
P41EB024495Resource for Molecular Imaging Agents in Precision Medicine302,025NIH's project files
P50CA092629SPORE in Prostate Cancer302,025NIH's project files
P30CA016672Cancer Center Support Grant242,025NIH's project files

Papers 13509

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824820PubTator, text miningPubMed
42824310PubTator, text miningPubMed
42824302PubTator, text miningPubMed
42816307PubTator, text miningPubMed
42810296PubTator, text miningPubMed
42802891PubTator, text miningPubMed
42802268PubTator, text miningPubMed
42801739PubTator, text miningPubMed
42801636PubTator, text miningPubMed
42800445PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license