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Gene · 23462

HEY1: hes related family bHLH transcription factor with YRPW motif 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HEY1: hes related family bHLH transcription factor with YRPW motif 1. Genes, record 23462. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23462

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Gene

Symbol
HEY1
HGNC
Name
hes related family bHLH transcription factor with YRPW motif 1
HGNC
NCBI Gene ID
23462
NCBI Gene
HGNC ID
HGNC:4880
HGNC
Ensembl
ENSG00000164683
NCBI Gene
Aliases
BHLHb31, CHF-2, CHF2, HERP2, HESR-1, HESR1, HRT-1, NERP2, OAF1, bHLHb31, hHRT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y5J3Hairy/enhancer-of-split related with YRPW motif protein 13041Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025147176 A2025-10-0615078Q9Y5J3Espacenet
JP 2025028160 A2025-02-2815078Q9Y5J3Espacenet
KR 1020250010750 A2025-01-2115078Q9Y5J3Espacenet
EP 4491229 A22025-01-15100Q9Y5J3Espacenet
WO 2024230934 A12024-11-14225Q9Y5J3Espacenet
JP 2024109657 A2024-08-1414917Q9Y5J3Espacenet
US 11564998 B22023-01-315863Q9Y5J3Espacenet
US 11446398 B22022-09-2037944Q9Y5J3Espacenet
JP 2022092366 A2022-06-22580Q9Y5J3Espacenet
JP 2022524081 A2022-04-27140915Q9Y5J3Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,288

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHEY1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant252025
P30CA016672Cancer Center Support Grant212025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028102025
UL1TR001863Yale Clinical and Translational Science Award92025
P30CA006973Regional Oncology Research Center72025
P30CA016520Abramson Cancer Center Support Grant72025
P30CA010815Consolidated Basic Cancer Research Program62025
P30CA006516Dana-Farber/Harvard Cancer Center52025
P30CA015704Cancer Center Support Grant52025
P30CA168524The University of Kansas Cancer Center52025

1 to 10 of 2,288Source NIH's project files

See all 2,288 nih grants

Papers3,005

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Functional interplay between LSD1 and HDAC6 supports malignant phenotypes in breast cancer models and is associated with notch-related protein changes.Cell Signal202642805446PubTator, text miningPubMed
Establishment of a cell line-based 3-D coculture model of the endometrium for studying endometrial receptivity.Am J Physiol Cell Physiol202642775555PubTator, text miningPubMed
Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte-to-DC Differentiation Via Microbiota-Associated IAA.Adv Sci (Weinh)202642750356PubTator, text miningPubMed
PM10 Exposure Impairs Differentiation and Induces Inflammation in Human Small Airway Epithelial Cells Cultured at the Air-Liquid Interface.Tuberc Respir Dis (Seoul)202642693576PubTator, text miningPubMed
MLL1 Regulates T-Cell Phenotype via Notch Signaling During Abdominal Aortic Aneurysm Development.Arterioscler Thromb Vasc Biol202642619610PubTator, text miningPubMed
Integrin-Associated Signalling Regulates Jagged1-Induced Osteogenic Differentiation of Human Dental Pulp Stem Cells.Int Dent J202642607518PubTator, text miningPubMed
Anandamide modulates NOTCH1 signalling and inflammatory responses during human endometrial stromal cell decidualization.Reproduction202642606559PubTator, text miningPubMed
Bioinformatics and experimental studies of atherosclerosis-related endothelial dysfunction genes in renal calculi and exploration of their molecular mechanisms.PLoS One202642550868PubTator, text miningPubMed
Plectin 1d Isoform as a Potential Regulator of Metastatic Progression in Papillary Thyroid Carcinoma.Int J Mol Sci202642511682PubTator, text miningPubMed
Ion-Responsive Microneedles Delivering Subtype-Specific Mitochondrial Extracellular Vesicles from HEY1⁺ Cardiomyocytes for Cardiac Repair in Bama Minipigs with Myocardial Ischemia-Reperfusion Injury.Theranostics202642370197PubTator, text miningPubMed

1 to 10 of 3,005

See all 3,005 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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