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BRD4: bromodomain containing 4

1 protein, 53 patents, 6 drugs, 42 trials, 5,332 NIH grants and 9,687 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolBRD4HGNC
Namebromodomain containing 4HGNC
NCBI Gene ID23476NCBI Gene
HGNC IDHGNC:13575HGNC
EnsemblENSG00000141867NCBI Gene
AliasesCAP, CDLS6, FSHRG4, HUNK1, HUNKI, MCAPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O60885Bromodomain-containing protein 41,362624Ensembl, GeneID, HGNCUniProt

Patents 53

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439245O60885Espacenet
WO 2025243001 A12025-11-271O60885Espacenet
EP 4641201 A22025-10-291771O60885Espacenet
JP 2025517969 A2025-06-121771O60885Espacenet
JP 2025072508 A2025-05-093O60885Espacenet
JP 2025062604 A2025-04-149837O60885Espacenet
US 12161648 B22024-12-103O60885Espacenet
US 12084663 B22024-09-10375O60885Espacenet
US 12023385 B22024-07-023O60885Espacenet
JP 2023520371 A2023-05-17157O60885Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APABETALONECHEMBL2393130Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
BIRABRESIBCHEMBL3581647Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
EZOBRESIBCHEMBL4297458Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
MOLIBRESIBCHEMBL1232461Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
PELABRESIBCHEMBL4303404Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
RO-6870810CHEMBL4297423Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL

Trials 42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07357727PELABRESIBPHASE3ClinicalTrials.gov
NCT07340138PELABRESIBPHASE1ClinicalTrials.gov
NCT06590324APABETALONEPHASE2/PHASE3ClinicalTrials.gov
NCT06401356PELABRESIBPHASE3ClinicalTrials.gov
NCT05372354EZOBRESIBPHASE1/PHASE2ClinicalTrials.gov
NCT04915300APABETALONEPHASE2ClinicalTrials.gov
NCT04894266APABETALONEPHASE2/PHASE3ClinicalTrials.gov
NCT04817007EZOBRESIBPHASE1/PHASE2ClinicalTrials.gov
NCT04603495PELABRESIBPHASE32024-10-28ClinicalTrials.gov
NCT03936465EZOBRESIBPHASE1ClinicalTrials.gov

NIH grants 5332

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1032,025NIH's project files
P30CA016672Cancer Center Support Grant772,025NIH's project files
R01CA124633Pathogenesis and Treatment of NUT midline carcinoma292,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)272,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias262,025NIH's project files
P30CA045508CSHL Cancer Center Support Grant262,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research252,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program252,025NIH's project files
R35CA197589Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities252,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant242,025NIH's project files

Papers 9687

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822413PubTator, text miningPubMed
42820755PubTator, text miningPubMed
42818321PubTator, text miningPubMed
42818240PubTator, text miningPubMed
42818227PubTator, text miningPubMed
42816348PubTator, text miningPubMed
42814605PubTator, text miningPubMed
42801629PubTator, text miningPubMed
42798998PubTator, text miningPubMed
42792755PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license