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Gene · 2348

FOLR1: folate receptor alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FOLR1: folate receptor alpha. Genes, record 2348. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2348

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Gene

Symbol
FOLR1
HGNC
Name
folate receptor alpha
HGNC
NCBI Gene ID
2348
NCBI Gene
HGNC ID
HGNC:3791
HGNC
Ensembl
ENSG00000110195
NCBI Gene
Aliases
FBP, FOLR, FR-alpha, FRalpha, FRα, NCFTD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P15328Folate receptor alpha2575Ensembl, GeneID, HGNC

Source UniProt

Patents538

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026169921 A12026-08-1337P15328Espacenet
EP 4772183 A22026-07-081P15328Espacenet
EP 4741423 A22026-05-1312P15328Espacenet
US 12600781 B22026-04-14139P15328Espacenet
EP 4684803 A12026-01-2812P15328Espacenet
JP 2026004432 A2026-01-1449P15328Espacenet
JP 2026004568 A2026-01-1446491P15328Espacenet
JP 2026004568 A2026-01-1446492P15328Espacenet
JP 2026004568 A2026-01-1446493P15328Espacenet
JP 2026004568 A2026-01-1446494P15328Espacenet

1 to 10 of 538

See all 538 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FARLETUZUMABCHEMBL1743016Folate receptor alpha inhibitorINHIBITORChEMBL
MIRVETUXIMABCHEMBL3545192Folate receptor alpha binding agentBINDING AGENTChEMBL
MIRVETUXIMAB SORAVTANSINECHEMBL3545132Folate receptor alpha binding agentBINDING AGENTChEMBL
VINTAFOLIDECHEMBL3039521Folate receptor alpha binding agentBINDING AGENTChEMBL

Trials46

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07218809MIRVETUXIMAB SORAVTANSINEPHASE3ClinicalTrials.gov
NCT07059845MIRVETUXIMAB SORAVTANSINEPHASE2ClinicalTrials.gov
NCT06890338MIRVETUXIMAB SORAVTANSINEPHASE2ClinicalTrials.gov
NCT06682988MIRVETUXIMAB SORAVTANSINEPHASE2ClinicalTrials.gov
NCT06390995MIRVETUXIMAB SORAVTANSINEPHASE1/PHASE2ClinicalTrials.gov
NCT05887609MIRVETUXIMAB SORAVTANSINEPHASE2ClinicalTrials.gov
NCT05622890MIRVETUXIMAB SORAVTANSINEPHASE3ClinicalTrials.gov
NCT05604209FARLETUZUMABPHASE12025-08-24ClinicalTrials.gov
NCT05483933MIRVETUXIMAB SORAVTANSINEPHASE12025-12-23ClinicalTrials.gov
NCT05456685MIRVETUXIMAB SORAVTANSINEPHASE2ClinicalTrials.gov

1 to 10 of 46

See all 46 trials

NIH grants1,396

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFOLR1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant372025
P30CA016672Cancer Center Support Grant162025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer152025
T32CA009531Training Program in the Biology of Cancer132025
P30CA022453CANCER CENTER SUPPORT GRANT112025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant82025
P30CA016359Cancer Center Support Grant72025
P30CA016520Abramson Cancer Center Support Grant72025
P01CA254859Intraoperative Near Infrared Molecular Imaging of Lung Cancer62025
P30CA006973Regional Oncology Research Center62025

1 to 10 of 1,396Source NIH's project files

See all 1,396 nih grants

Papers3,253

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Label-free fiber-optic cascade sensor for rapid and ultrasensitive serum folate quantification.Talanta202742691716PubTator, text miningPubMed
DOTAM-TCB: Universal Small Molecule-guided Hapten- and T Cell-bispecific Antibodies for Cancer Immunotherapy.Antib Ther202642824820PubTator, text miningPubMed
Biomarker-Driven Treatments for Ovarian Cancer: Moving Beyond HRD?Int J Womens Health202642824309PubTator, text miningPubMed
An integrated microfluidic platform for tunable-stringency competitive affinity selection of folate receptor alpha aptamers.Lab Chip202642820463PubTator, text miningPubMed
Plasma and cerebrospinal fluid proteomics reveal distinct patterns of senescence and neuropathology in aging rhesus macaques.Geroscience202642799938PubTator, text miningPubMed
Prenatal Folinic Acid in FRAA-Positive Pregnancies: Preschool Neurodevelopmental Outcomes from a Pilot RCT Follow-Up.Nutrients202642796952PubTator, text miningPubMed
Search for leukemia-restricted targets: a new paradigm for precision immunotherapy in acute myeloid leukemia.Haematologica202642779343PubTator, text miningPubMed
Near-Infrared Fluorescent Zwitterionic Folic Acid Probe and Serum CA125 for Enhancing Diagnostic Accuracy of Malignant Ovarian Cancer Ascites.Technol Cancer Res Treat202642753264PubTator, text miningPubMed
Post-marketing safety assessment of mirvetuximab soravtansine: a disproportionality analysis based on the FDA Adverse Event Reporting System.J Gynecol Oncol202642750304PubTator, text miningPubMed
Comparative Transcriptomic and Immune Profiling Reveals a Shared Molecular Identity Between Clear Cell Odontogenic Carcinoma and Hyalinizing Clear Cell Carcinoma.Mol Cancer Res202642743086PubTator, text miningPubMed

1 to 10 of 3,253

See all 3,253 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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