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Gene · 23493

HEY2: hes related family bHLH transcription factor with YRPW motif 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HEY2: hes related family bHLH transcription factor with YRPW motif 2. Genes, record 23493. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23493

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Gene

Symbol
HEY2
HGNC
Name
hes related family bHLH transcription factor with YRPW motif 2
HGNC
NCBI Gene ID
23493
NCBI Gene
HGNC ID
HGNC:4881
HGNC
Ensembl
ENSG00000135547
NCBI Gene
Aliases
CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UBP5Hairy/enhancer-of-split related with YRPW motif protein 23370Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448655Q9UBP5Espacenet
JP 2025147176 A2025-10-0615079Q9UBP5Espacenet
JP 2025032204 A2025-03-1129540Q9UBP5Espacenet
JP 2025028160 A2025-02-2815079Q9UBP5Espacenet
KR 1020250010750 A2025-01-2115079Q9UBP5Espacenet
EP 4461818 A22024-11-1329540Q9UBP5Espacenet
JP 2024109657 A2024-08-1414918Q9UBP5Espacenet
JP 2023058610 A2023-04-2529540Q9UBP5Espacenet
US 11446398 B22022-09-2037947Q9UBP5Espacenet
JP 2022524081 A2022-04-27140918Q9UBP5Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,433

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHEY2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025
P30CA068485Cancer Center Support Grant52025
T32HL007208Integrated, Multidisciplinary Training in Cardiovascular Research52025
U54CA1186381/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA008748Cancer Center Support Grant42025
P30CA010815Consolidated Basic Cancer Research Program42025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment42025
T32HL007381Cardiovascular Sciences Training Grant42025

1 to 10 of 1,433Source NIH's project files

See all 1,433 nih grants

Papers1,569

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Establishment of a cell line-based 3-D coculture model of the endometrium for studying endometrial receptivity.Am J Physiol Cell Physiol202642775555PubTator, text miningPubMed
MLL1 Regulates T-Cell Phenotype via Notch Signaling During Abdominal Aortic Aneurysm Development.Arterioscler Thromb Vasc Biol202642619610PubTator, text miningPubMed
Identification of genes differentially expressed in granulosa cells from women with high vs. low ovarian responsiveness.Front Reprod Health202642358728PubTator, text miningPubMed
Relationship of oxytocin and cortisol response to psychosocial stress in children and adolescents with anxiety disorders.Sci Rep202641888549PubTator, text miningPubMed
ESRP1-Associated CD44 Alternative Splicing Stratifies Epithelial-Mesenchymal Identity States in a Non-Transformed Human Cell System.Curr Issues Mol Biol202641751394PubTator, text miningPubMed
A Comprehensive Adenoid Cystic Carcinoma-Derived Organoid Platform for Disease Modeling and Drug Screening Captures Interpatient Heterogeneity.Cells202641744826PubTator, text miningPubMed
Prdm16 Amplifies Notch Signaling and Suppresses Venous Lineage Specification to Prevent Arteriovenous Malformations During Vascular Development.Arterioscler Thromb Vasc Biol202641711027PubTator, text miningPubMed
A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis.Nat Commun202641547848PubTator, text miningPubMed
Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes.Nat Commun202641526351PubTator, text miningPubMed
GATA6 inhibits the periodontitis progression through regulating the Notch signaling pathway.Odontology202640788377PubTator, text miningPubMed

1 to 10 of 1,569

See all 1,569 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23493

GET https://conductscience.org/api/genes/v1/23493/patents?page=2