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Gene · 23498

HAAO: 3-hydroxyanthranilate 3,4-dioxygenase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HAAO: 3-hydroxyanthranilate 3,4-dioxygenase. Genes, record 23498. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23498

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Gene

Symbol
HAAO
HGNC
Name
3-hydroxyanthranilate 3,4-dioxygenase
HGNC
NCBI Gene ID
23498
NCBI Gene
HGNC ID
HGNC:4796
HGNC
Ensembl
ENSG00000162882
NCBI Gene
Aliases
3-HAO, HAO, VCRL1, h3HAO
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P469523-hydroxyanthranilate 3,4-dioxygenase2863Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-29461P46952Espacenet
EP 4641201 A22025-10-293177P46952Espacenet
JP 2025519096 A2025-06-24461P46952Espacenet
JP 2025517969 A2025-06-123177P46952Espacenet
JP 2025062604 A2025-04-14237P46952Espacenet
US 11564998 B22023-01-315145P46952Espacenet
US 11446398 B22022-09-20237P46952Espacenet
JP 2022524081 A2022-04-27103208P46952Espacenet
US 11078247 B22021-08-034844P46952Espacenet
JP 2020062004 A2020-04-231546P46952Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants802

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHAAO papersNewest fiscal year
R01AI059374Adenoviral Vector-based Pandemic Influenza Vaccine92025
R01AI103280MEP pathway resistance in Plasmodium falciparum62025
R01GM108988Heme-Dependent Chemistry in Aromatic Oxidation52025
P30CA008748Cancer Center Support Grant32025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).32025
UL1TR001863Yale Clinical and Translational Science Award32025
P30AG028747University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC)22025
P30AI050409Center for AIDS Research at Emory University22025
P30AI060354Harvard University Center for AIDS Research22025
P30CA006516Dana-Farber/Harvard Cancer Center22025

1 to 10 of 802Source NIH's project files

See all 802 nih grants

Papers1,372

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Biallelic Variants in KMO Cause a Novel Form of Congenital NAD Deficiency.medRxiv202642798303PubTator, text miningPubMed
Micro-aeration unlocks endogenous nitrogen removal in anaerobic digesters via metabolically versatile fermentative bacteria.Water Res202642691671PubTator, text miningPubMed
Effects of pristine and citrate-coated zinc oxide nanoparticles on soil nitrogen cycling determined using multi-level assessment of enzyme activity, functional gene abundance and microbial community composition.
Environ Sci Pollut Res Int202642455285PubTator, text miningPubMed
HAAO‑derived quinolinic acid fuels FDPS‑dependent AR signaling and sensitizes prostate cancer to combination therapy.Cell Death Discov202642303969PubTator, text miningPubMed
Mechanistic insights into superior biofilm formation with heterotrophic nitrification-aerobic denitrification bacteria under polypropylene microplastic stress.Bioresour Technol202642289247PubTator, text miningPubMed
Integrated metagenomics unravels the microbial mechanisms driving greenhouse gas and odor emissions during composting.Bioresour Technol202642190956PubTator, text miningPubMed
Dimerization-Dependent Trans-Domain Coupling Enables Intermediate Transfer in Fungal Haloacid Dehalogenase-Like Terpene Cyclases.J Am Chem Soc202642139319PubTator, text miningPubMed
First evidence of the H-bonding with picoloylated compounds used as building blocks for HAD.Carbohydr Res202642127496PubTator, text miningPubMed
Citric acid-driven metabolic regulation strategy for coordinating nitrogen retention and phosphorus activation in aerobic composting.Bioresour Technol202642119612PubTator, text miningPubMed
Stage-Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune-Related Involvement in Bladder Cancer Progression.Int J Urol202642095396PubTator, text miningPubMed

1 to 10 of 1,372

See all 1,372 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23498

GET https://conductscience.org/api/genes/v1/23498/patents