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Gene · 23533

PIK3R5: phosphoinositide-3-kinase regulatory subunit 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIK3R5: phosphoinositide-3-kinase regulatory subunit 5. Genes, record 23533. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23533

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Gene

Symbol
PIK3R5
HGNC
Name
phosphoinositide-3-kinase regulatory subunit 5
HGNC
NCBI Gene ID
23533
NCBI Gene
HGNC ID
HGNC:30035
HGNC
Ensembl
ENSG00000141506
NCBI Gene
Aliases
F730038I15Rik, FOAP-2, P101-PI3K, p101
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8WYR1Phosphoinositide 3-kinase regulatory subunit 58800Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2913798Q8WYR1Espacenet
JP 2025517969 A2025-06-1213798Q8WYR1Espacenet
JP 2024123008 A2024-09-107640Q8WYR1Espacenet
JP 2024123008 A2024-09-107641Q8WYR1Espacenet
US 11446398 B22022-09-2063172Q8WYR1Espacenet
US 11446398 B22022-09-2063174Q8WYR1Espacenet
JP 2022524081 A2022-04-27166143Q8WYR1Espacenet
JP 2022524081 A2022-04-27166145Q8WYR1Espacenet
US 11078247 B22021-08-038487Q8WYR1Espacenet
US 10918740 B22021-02-169242Q8WYR1Espacenet

1 to 10 of 36

See all 36 patents

Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APITOLISIBCHEMBL1922094PI3-kinase class I inhibitorINHIBITORChEMBL
AZD-6482CHEMBL2165191PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226CHEMBL3545096PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226 FREE BASECHEMBL3218578PI3-kinase class I inhibitorINHIBITORChEMBL
BUPARLISIBCHEMBL2017974PI3-kinase class I inhibitorINHIBITORChEMBL
DACTOLISIBCHEMBL1879463PI3-kinase class I inhibitorINHIBITORChEMBL
DS-7423CHEMBL3545248PI3-kinase class I inhibitorINHIBITORChEMBL
GEDATOLISIBCHEMBL592445PI3-kinase class I inhibitorINHIBITORChEMBL
GSK-1059615CHEMBL3544966PI3-kinase class I inhibitorINHIBITORChEMBL
IZORLISIBCHEMBL1684984PI3-kinase class I inhibitorINHIBITORChEMBL

1 to 10 of 28

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Trials203

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07447076PAXALISIBPHASE2ClinicalTrials.gov
NCT07391215PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT07287202PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT06757634GEDATOLISIBPHASE3ClinicalTrials.gov
NCT06208657PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT06190899GEDATOLISIBPHASE1/PHASE2ClinicalTrials.gov
NCT05501886GEDATOLISIBPHASE3ClinicalTrials.gov
NCT05183204PAXALISIBPHASE2ClinicalTrials.gov
NCT05009992PAXALISIBPHASE2ClinicalTrials.gov
NCT04906096PAXALISIBPHASE2ClinicalTrials.gov

1 to 10 of 203

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NIH grants680

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIK3R5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant62025
P30CA043703Case Comprehensive Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
I01BX002301Combining Immune Therapy with Targeted Therapies to Improve Melanoma Survival22025
K12CA090625Vanderbilt Clinical Oncology Research Career Development Award22025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN22025
P30AI060354Harvard University Center for AIDS Research22025
R01CA167426Role of PI3Kgamma in Tumor Progression and Metastasis22025
R35GM136397GPCR anterograde trafficking22025

1 to 10 of 680Source NIH's project files

See all 680 nih grants

Papers819

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Serglycin-ROS axis mediates synergistic lethality of PI3Kγ inhibition and Azacitidine in TP53-mutated AML.BMC Cancer202642464230PubTator, text miningPubMed
Systemic Drug Effects in Vortioxetine-Induced Time-Series Datasets.Int J Mol Sci202642450323PubTator, text miningPubMed
Screening of Inflammatory Biomarkers in Atherosclerosis Based on WGCNA Analysis and Machine Learning.Curr Mol Med202642227555PubTator, text miningPubMed
Mapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning.Nat Commun202642056104PubTator, text miningPubMed
Leveraging Deep Learning to Construct a Programmed Cell Death-Driven Prognostic Signature in Acute Myeloid Leukemia.Curr Issues Mol Biol202642042014PubTator, text miningPubMed
ALOX5 Expression and Pathomics Features Reveal New Insights Into Lung Adenocarcinoma Prognosis: Model Construction and Functional Validation.Hum Mutat202641809565PubTator, text miningPubMed
New Dual Pan-PI3K/mTOR Inhibitor: Design, Synthesis, Cytotoxic Action, Permeation, Metabolic Stability, and In Silico Protein-Ligand Interaction.ACS Omega202641726721PubTator, text miningPubMed
NF-κB and STAT3 signaling uniquely stratify survival in female glioblastoma patients.iScience202641716996PubTator, text miningPubMed
Effects of ascorbic acid on trabecular meshwork gene expression and collagen secretion.BMJ Open Ophthalmol202641692493PubTator, text miningPubMed
The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke.Sci Rep202541136446PubTator, text miningPubMed

1 to 10 of 819

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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