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Gene · 23576

DDAH1: dimethylarginine dimethylaminohydrolase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DDAH1: dimethylarginine dimethylaminohydrolase 1. Genes, record 23576. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23576

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Gene

Symbol
DDAH1
HGNC
Name
dimethylarginine dimethylaminohydrolase 1
HGNC
NCBI Gene ID
23576
NCBI Gene
HGNC ID
HGNC:2715
HGNC
Ensembl
ENSG00000153904
NCBI Gene
Aliases
DDAH, DDAH-1, DDAHI, HEL-S-16
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O94760N(G),N(G)-dimethylarginine dimethylaminohydrolase 128514Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443810O94760Espacenet
JP 2026004568 A2026-01-1443813O94760Espacenet
EP 4650780 A22025-11-193215O94760Espacenet
JP 2025517970 A2025-06-123215O94760Espacenet
JP 2022548026 A2022-11-164O94760Espacenet
JP 2022548026 A2022-11-1614O94760Espacenet
US 11446398 B22022-09-2024457O94760Espacenet
US 11446398 B22022-09-2024459O94760Espacenet
JP 2022524081 A2022-04-27127428O94760Espacenet
JP 2022524081 A2022-04-27127430O94760Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants772

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDAH1 papersNewest fiscal year
R01HL060190Metabolic reprogramming of smooth muscle cells in pulmonary hypertension52025
ZIAAI001150Nitric Oxide and Endothelial Function in Patients with Malaria32025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA016672Cancer Center Support Grant22025
P30CA021765Cancer Center Support Grant (CCSG)22025
P30CA068485Cancer Center Support Grant22025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant22025
R01HL140411Distinct Pathways of VPF/VEGF Receptors22025
R01NS017950Precursors of Stroke Incidence and Prognosis22025
R24AI067039CFAR Network of Integrated Clinical Systems (CNICS)22025

1 to 10 of 772Source NIH's project files

See all 772 nih grants

Papers1,467

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Causal Effects of Plasma Metabolites on Intervertebral Disc Degeneration and Low Back Pain: A Mendelian Randomization Study.Metabolites202642783798PubTator, text miningPubMed
Protein arginine methyltransferases in cardiovascular disease: mechanisms, therapeutic potential, and future directions.Front Physiol202642746277PubTator, text miningPubMed
Dimethylarginine Dimethylaminohydrolase 1 (DDAH1)-Arginine Metabolic Axis Is Independently Associated With Alzheimer's Disease Risk in the UK Biobank.Cureus202642729959PubTator, text miningPubMed
Structure- and Ligand-Based Discovery of Novel Non-Arginine-Based DDAH1 Inhibitors with Anti-Triple-Negative Breast Cancer Activity.ACS Med Chem Lett202642621519PubTator, text miningPubMed
DDAH1 and DDAH2 drive vasculogenic mimicry and more aggressive phenotypes in triple negative breast cancer cells.Biomed Pharmacother202642430838PubTator, text miningPubMed
Proton pump inhibitor target genes and asthma susceptibility: a Mendelian randomization study with identification of IL-2 as a potential mediator.J Asthma202642421242PubTator, text miningPubMed
A molecular perspective on dimethylarginine dimethylaminohydrolases structure and function.Biochem J202642339772PubTator, text miningPubMed
An appraisal of the role of asymmetric dimethylarginine on endothelial impairment in preeclampsia comorbid with HIV infection.Front Med (Lausanne)202642180710PubTator, text miningPubMed
Sarcopenia and chronic pain: Identification of shared genetic determinants and therapeutic implication.Medicine (Baltimore)202642152289PubTator, text miningPubMed
Endothelial and cardiac dysfunction in long COVID With cardiovascular symptoms is associated with imbalance in the ADMA-DDAH-NOx pathway.Front Cardiovasc Med202642095154PubTator, text miningPubMed

1 to 10 of 1,467

See all 1,467 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23576

GET https://conductscience.org/api/genes/v1/23576/patents?page=2