Gene · 23581
CASP14: caspase 14
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CASP14: caspase 14. Genes, record 23581. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23581
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P31944 | Caspase-14 | 242 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents95
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026082974 A | 2026-05-19 | 111 | P31944 | Espacenet |
| US 12539325 B2 | 2026-02-03 | 31 | P31944 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 13869 | P31944 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 13869 | P31944 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12249 | P31944 | Espacenet |
| US 12133879 B2 | 2024-11-05 | 31 | P31944 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5334 | P31944 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5335 | P31944 | Espacenet |
| US 11988676 B2 | 2024-05-21 | 20 | P31944 | Espacenet |
| JP 2024038290 A | 2024-03-19 | 20 | P31944 | Espacenet |
1 to 10 of 95
See all 95 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| EMRICASAN | CHEMBL197672 | Caspase inhibitor | INHIBITOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04803227 | EMRICASAN | PHASE1 | ClinicalTrials.gov | |
| NCT03205345 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02686762 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02230683 | EMRICASAN | PHASE2 | 2016-12-21 | ClinicalTrials.gov |
| NCT02230670 | EMRICASAN | PHASE2 | 2017-07-05 | ClinicalTrials.gov |
| NCT02138253 | EMRICASAN | PHASE2 | 2019-12-11 | ClinicalTrials.gov |
| NCT02077374 | EMRICASAN | PHASE2 | 2016-07-21 | ClinicalTrials.gov |
| NCT01937130 | EMRICASAN | PHASE2 | 2016-04-11 | ClinicalTrials.gov |
| NCT01912404 | EMRICASAN | PHASE2 | 2016-11-04 | ClinicalTrials.gov |
| NCT01653899 | EMRICASAN | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants652
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CASP14 papers | Newest fiscal year |
|---|---|---|---|
| R01GM100482 | Center for Critical Assessment of Structure Prediction (CASP) | 20 | 2025 |
| R01AI134678 | Structure-based functional annotation of microbial genomes | 8 | 2025 |
| R01GM146340 | Deep learning methods for automated and accurate reconstruction of protein structures from cryo-EM image data | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 3 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 3 | 2025 |
| R35GM118078 | Analysis and Prediction of Molecular Interactions | 3 | 2025 |
| R35GM141818 | Hybrid Methods for Dynamic Structure Analysis of Proteins from Pathogenic Microorganisms | 3 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 2 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 652Source NIH's project files
See all 652 nih grantsPapers1,191
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Trans-resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis. | Int J Cosmet Sci | 2026 | 42572371 | PubTator, text mining | PubMed |
| Identification of key candidate genes for body weight traits in male Dongfeng sika deer based on genome-wide association analysis. | Sci Rep | 2026 | 42277116 | PubTator, text mining | PubMed |
| The EGR1/caspase-14/HIF-1α axis mediates tamoxifen resistance in MCF-7 breast cancer cells. | Open Life Sci | 2026 | 42117041 | PubTator, text mining | PubMed |
| Molecular Mechanism of Caspase-8-Dependent Interleukin-18 Activation in Pancreatic Cancer Cells Induced by 5-Fluorouracil and Nutrient Starvation. | Genes Cells | 2026 | 41940532 | PubTator, text mining | PubMed |
| ECOD: Classification of domains in AFDB Swiss-Prot structure predictions. | PLoS Comput Biol | 2026 | 41911251 | PubTator, text mining | PubMed |
| Age-dependent reductions in natural moisturizing factor and caspase-14 in paediatric atopic dermatitis. | J Eur Acad Dermatol Venereol | 2026 | 41854176 | PubTator, text mining | PubMed |
| Efficacy and safety of common Chinese herbal medicines in treating psoriasis: a systematic review and meta-analysis. | Front Pharmacol | 2026 | 41800105 | PubTator, text mining | PubMed |
| Systematic Identification of Molecular Signatures Dictating Therapeutic Effects of Clinically First-Line Chemotherapy Regimens for Human Gastric Cancer Patients Based on Organoid Model. | MedComm (2020) | 2026 | 41782964 | PubTator, text mining | PubMed |
| Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils. | Pediatr Allergy Immunol | 2026 | 41760554 | PubTator, text mining | PubMed |
| MAKA-Map: Real-Valued Distance Prediction for Protein Folding Mechanisms via a Hybrid Neural Framework Integrating the Mamba and Kolmogorov-Arnold Networks. | Biomolecules | 2026 | 41750265 | PubTator, text mining | PubMed |
1 to 10 of 1,191
See all 1,191 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23581
GET https://conductscience.org/api/genes/v1/23581/patents?page=2