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Gene · 23581

CASP14: caspase 14

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CASP14: caspase 14. Genes, record 23581. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23581

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Gene

Symbol
CASP14
HGNC
Name
caspase 14
HGNC
NCBI Gene ID
23581
NCBI Gene
HGNC ID
HGNC:1502
HGNC
Ensembl
ENSG00000105141
NCBI Gene
Aliases
ARCI12, MGC119078, MGC119079, MICE, caspase-14
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P31944Caspase-142420Ensembl, GeneID, HGNC

Source UniProt

Patents95

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082974 A2026-05-19111P31944Espacenet
US 12539325 B22026-02-0331P31944Espacenet
EP 4641201 A22025-10-2913869P31944Espacenet
JP 2025517969 A2025-06-1213869P31944Espacenet
JP 2025062604 A2025-04-1412249P31944Espacenet
US 12133879 B22024-11-0531P31944Espacenet
JP 2024123008 A2024-09-105334P31944Espacenet
JP 2024123008 A2024-09-105335P31944Espacenet
US 11988676 B22024-05-2120P31944Espacenet
JP 2024038290 A2024-03-1920P31944Espacenet

1 to 10 of 95

See all 95 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
EMRICASANCHEMBL197672Caspase inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants652

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCASP14 papersNewest fiscal year
R01GM100482Center for Critical Assessment of Structure Prediction (CASP)202025
R01AI134678Structure-based functional annotation of microbial genomes82025
R01GM146340Deep learning methods for automated and accurate reconstruction of protein structures from cryo-EM image data42025
P30CA008748Cancer Center Support Grant32025
P30CA014520UW Comprehensive Cancer Center Support32025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
R35GM118078Analysis and Prediction of Molecular Interactions32025
R35GM141818Hybrid Methods for Dynamic Structure Analysis of Proteins from Pathogenic Microorganisms32025
P30CA016058Cancer Center Support Grant22025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant22025

1 to 10 of 652Source NIH's project files

See all 652 nih grants

Papers1,191

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Trans-resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis.Int J Cosmet Sci202642572371PubTator, text miningPubMed
Identification of key candidate genes for body weight traits in male Dongfeng sika deer based on genome-wide association analysis.Sci Rep202642277116PubTator, text miningPubMed
The EGR1/caspase-14/HIF-1α axis mediates tamoxifen resistance in MCF-7 breast cancer cells.Open Life Sci202642117041PubTator, text miningPubMed
Molecular Mechanism of Caspase-8-Dependent Interleukin-18 Activation in Pancreatic Cancer Cells Induced by 5-Fluorouracil and Nutrient Starvation.Genes Cells202641940532PubTator, text miningPubMed
ECOD: Classification of domains in AFDB Swiss-Prot structure predictions.PLoS Comput Biol202641911251PubTator, text miningPubMed
Age-dependent reductions in natural moisturizing factor and caspase-14 in paediatric atopic dermatitis.J Eur Acad Dermatol Venereol202641854176PubTator, text miningPubMed
Efficacy and safety of common Chinese herbal medicines in treating psoriasis: a systematic review and meta-analysis.Front Pharmacol202641800105PubTator, text miningPubMed
Systematic Identification of Molecular Signatures Dictating Therapeutic Effects of Clinically First-Line Chemotherapy Regimens for Human Gastric Cancer Patients Based on Organoid Model.MedComm (2020)202641782964PubTator, text miningPubMed
Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils.Pediatr Allergy Immunol202641760554PubTator, text miningPubMed
MAKA-Map: Real-Valued Distance Prediction for Protein Folding Mechanisms via a Hybrid Neural Framework Integrating the Mamba and Kolmogorov-Arnold Networks.Biomolecules202641750265PubTator, text miningPubMed

1 to 10 of 1,191

See all 1,191 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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