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BACE1: beta-secretase 1

1 protein, 101 patents, 4 drugs, 15 trials, 3,988 NIH grants and 10,640 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolBACE1HGNC
Namebeta-secretase 1HGNC
NCBI Gene ID23621NCBI Gene
HGNC IDHGNC:933HGNC
EnsemblENSG00000186318NCBI Gene
AliasesASP2, Asp2, BACE, HSPC104NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P56817Beta-secretase 1501431Ensembl, GeneID, HGNCUniProt

Patents 101

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195198P56817Espacenet
EP 4641201 A22025-10-294785P56817Espacenet
JP 2025529142 A2025-09-04561P56817Espacenet
US 12371689 B22025-07-29561P56817Espacenet
KR 1020250105736 A2025-07-0914P56817Espacenet
WO 2025126267 A2025-06-1913P56817Espacenet
WO 2025127056 A2025-06-1913P56817Espacenet
JP 2025517969 A2025-06-124785P56817Espacenet
JP 2025517970 A2025-06-125198P56817Espacenet
JP 2025062604 A2025-04-149057P56817Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATABECESTATCHEMBL3916243Beta-secretase 1 inhibitorINHIBITORChEMBL
ELENBECESTATCHEMBL4204869Beta-secretase 1 inhibitorINHIBITORChEMBL
LANABECESTATCHEMBL3989948Beta-secretase 1 inhibitorINHIBITORChEMBL
VERUBECESTATCHEMBL3301601Beta-secretase 1 inhibitorINHIBITORChEMBL

Trials 15

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02972658LANABECESTATPHASE32019-07-05ClinicalTrials.gov
NCT02956486ELENBECESTATPHASE32021-02-03ClinicalTrials.gov
NCT02783573LANABECESTATPHASE32019-08-06ClinicalTrials.gov
NCT02569398ATABECESTATPHASE2/PHASE32020-02-10ClinicalTrials.gov
NCT02540668LANABECESTATPHASE12019-03-25ClinicalTrials.gov
NCT02406027ATABECESTATPHASE22019-09-09ClinicalTrials.gov
NCT02360657ATABECESTATPHASE1ClinicalTrials.gov
NCT02322021ELENBECESTATPHASE22021-03-05ClinicalTrials.gov
NCT02260674ATABECESTATPHASE2ClinicalTrials.gov
NCT02245737LANABECESTATPHASE2/PHASE32019-08-06ClinicalTrials.gov

NIH grants 3988

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)252,025NIH's project files
P20GM109025Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission222,025NIH's project files
ZIAAG000311ALZHEIMERS RESEARCH PROJECT: Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)182,025NIH's project files
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study172,025NIH's project files
R01AG046929Inhibition of BACE1 for benefiting Alzheimer's patients152,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center102,025NIH's project files
P30AG072980Arizona Alzheimer's Disease Research Center92,025NIH's project files
P30CA008748Cancer Center Support Grant82,025NIH's project files
P51OD011132Emory National Primate Research Center82,025NIH's project files
P30AG072975Rush Alzheimer's Disease Research Center72,025NIH's project files

Papers 10640

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826722PubTator, text miningPubMed
42824999PubTator, text miningPubMed
42819414PubTator, text miningPubMed
42818224PubTator, text miningPubMed
42802722PubTator, text miningPubMed
42793112PubTator, text miningPubMed
42790732PubTator, text miningPubMed
42776425PubTator, text miningPubMed
42764330PubTator, text miningPubMed
42760283PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license