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Gene · 23645

PPP1R15A: protein phosphatase 1 regulatory subunit 15A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPP1R15A: protein phosphatase 1 regulatory subunit 15A. Genes, record 23645. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23645

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Gene

Symbol
PPP1R15A
HGNC
Name
protein phosphatase 1 regulatory subunit 15A
HGNC
NCBI Gene ID
23645
NCBI Gene
HGNC ID
HGNC:14375
HGNC
Ensembl
ENSG00000087074
NCBI Gene
Aliases
GADD34
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75807Protein phosphatase 1 regulatory subunit 15A6744Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19205O75807Espacenet
EP 4641202 A22025-10-294299O75807Espacenet
JP 2025517970 A2025-06-12205O75807Espacenet
JP 2025032204 A2025-03-1133959O75807Espacenet
JP 2025505936 A2025-03-055O75807Espacenet
KR 1020250017231 A2025-02-044299O75807Espacenet
EP 4472664 A12024-12-115O75807Espacenet
EP 4461818 A22024-11-1333959O75807Espacenet
JP 2024123008 A2024-09-107878O75807Espacenet
US 11873486 B22024-01-1627O75807Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,798

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPP1R15A papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
R01CA109182Functional Determinants of Metastatic Dormancy82025
P30CA008748Cancer Center Support Grant72025
P30CA047904Cancer Center Support Grant72025
ZIAHD001010Mechanism and Regulation of Eukaryotic Protein Synthesis72025
R01DK060596Translational control by nutrients62025
P30CA016058Cancer Center Support Grant52025
P30CA030199Cancer Center Support Grant (CCSG)52025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant52025
P30CA021765Cancer Center Support Grant (CCSG)42025

1 to 10 of 1,798Source NIH's project files

See all 1,798 nih grants

Papers2,536

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Synthesis and biological evaluation of cyanoenone- and enone-fused 4-androstene-3,17-dione derivatives against triple-negative breast cancer.Bioorg Chem202642748754PubTator, text miningPubMed
Proteostasis in the regulation of pancreatic islet cell plasticity.J Diabetes Investig202642723547PubTator, text miningPubMed
Enhancing lysosome function via TFEB activation reduces lipofuscin-like granules in the retinal pigment epithelium.Exp Eye Res202642637174PubTator, text miningPubMed
Patient-specific iPSC-derived ECs identify QKI-7 as a key regulator of endothelial dysfunction and potential therapeutic target in diabetes.Stem Cells Transl Med202642560887PubTator, text miningPubMed
GRHAL1, a novel lncRNA, regulates HIV-1 gene expression by modulating Tat- and Sp1-mediated HIV-1 LTR activation.J Gen Virol202642391287PubTator, text miningPubMed
Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer.Adv Sci (Weinh)202642371785PubTator, text miningPubMed
TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites.Nat Commun202642248860PubTator, text miningPubMed
Integrated transcriptomic profiling of programmed cell death patterns unveils macrophage-hepatocyte crosstalk via THBS1-CD47 axis in hepatic ischemia-reperfusion injury.Front Immunol202642238567PubTator, text miningPubMed
Identification of Autophagy-Associated Molecular Signatures in Osteoarthritis Revealed by Integrative Multi-Omics and Experimental Validation.Chem Biol Drug Des202642233387PubTator, text miningPubMed
Identification and validation of autophagy-related genes in keratoconus and their correlation with immune infiltration.Medicine (Baltimore)202642216341PubTator, text miningPubMed

1 to 10 of 2,536

See all 2,536 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23645

GET https://conductscience.org/api/genes/v1/23645/patents?page=2