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Gene · 23649

POLA2: DNA polymerase alpha 2, accessory subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POLA2: DNA polymerase alpha 2, accessory subunit. Genes, record 23649. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23649

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Gene

Symbol
POLA2
HGNC
Name
DNA polymerase alpha 2, accessory subunit
HGNC
NCBI Gene ID
23649
NCBI Gene
HGNC ID
HGNC:30073
HGNC
Ensembl
ENSG00000014138
NCBI Gene
Aliases
FLJ21662
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14181DNA polymerase alpha subunit B59813Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 11446398 B22022-09-2064908Q14181Espacenet
JP 2022524081 A2022-04-27167879Q14181Espacenet
US 11078247 B22021-08-038696Q14181Espacenet
JP 2019033757 A2019-03-0723980Q14181Espacenet
JP 2017123847 A2017-07-2023980Q14181Espacenet
US 9504734 B22016-11-295364Q14181Espacenet
US 9283287 B22016-03-155364Q14181Espacenet
JP 2015519881 A2015-07-1623980Q14181Espacenet
US 9050297 B22015-06-095364Q14181Espacenet
EP 2834358 A22015-02-115364Q14181Espacenet

1 to 10 of 23

See all 23 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASPACYTARABINECHEMBL4297599DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CLOFARABINECHEMBL1750DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CYTARABINECHEMBL803DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
FLUDARABINE PHOSPHATECHEMBL1096882DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINECHEMBL888DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINE HYDROCHLORIDECHEMBL1637DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
TROXACITABINECHEMBL359164DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL

Trials4,186

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766GEMCITABINEPHASE3ClinicalTrials.gov
NCT07604233CYTARABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07603557FLUDARABINE PHOSPHATEPHASE2ClinicalTrials.gov
NCT07602140GEMCITABINEPHASE2ClinicalTrials.gov
NCT07598318GEMCITABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07588360CYTARABINEClinicalTrials.gov
NCT07583888CYTARABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07579195GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07575191GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07570849GEMCITABINEPHASE2ClinicalTrials.gov

1 to 10 of 4,186

See all 4,186 trials

NIH grants354

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOLA2 papersNewest fiscal year
P30CA036727Buffett Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
R35CA210036Genome instability in cancer: telomeres and DNA repair32025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens22025
R01CA234266Molecular modulator of RAD51 in maintaining genome stability22025
R35GM122481Development and Testing of New Computational Methods for Ligand Discovery and Mechanism22025
R35GM131754Structural mechanism of DNA replication22025
T32AI060537Integrative Microbiology Program22025
U19AI135972SARS-CoV adaptations through a Systems Biology Lens (SYBIL)22025
U19AI135990HPMI: Host Pathogen Mapping Initiative22025

1 to 10 of 354Source NIH's project files

See all 354 nih grants

Papers419

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR.Genes Dev202642140672PubTator, text miningPubMed
Comprehensive Multi-Omics Characterization of CYP2R1 as a Diagnostic and Functional Biomarker in Hepatocellular Carcinoma.Med Sci (Basel)202642029602PubTator, text miningPubMed
An updated view on lagging strand DNA replication: implications for the replication stress response.Cell Cycle202641865289PubTator, text miningPubMed
Non-invasive host transcriptome and HPV oncogene expression map the molecular landscape of HPV-driven cervical lesions.PLoS One202641855211PubTator, text miningPubMed
Charting the multilevel molecular response to palbociclib in ER-positive breast cancer.NAR Cancer202641710088PubTator, text miningPubMed
Identification of FANCG as a prognostic factor for prostate cancer.Eur J Med Res202540635081PubTator, text miningPubMed
DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication.Nat Commun202540593507PubTator, text miningPubMed
A-to-I RNA edited POLA2 attains carcinogenesis in prostatic cancer by impeding immune infiltration and upregulating BTBD7.Discov Oncol202540366506PubTator, text miningPubMed
The identification and prediction of lung adenocarcinoma prognosis using a novel gene signature associated with DNA replication.Transl Cancer Res202540224989PubTator, text miningPubMed
Identification of biallelic POLA2 variants in two families with an autosomal recessive telomere biology disorder.Eur J Hum Genet202539616267PubTator, text miningPubMed

1 to 10 of 419

See all 419 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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