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Gene · 23743

BHMT2: betaine--homocysteine S-methyltransferase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BHMT2: betaine--homocysteine S-methyltransferase 2. Genes, record 23743. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23743

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Gene

Symbol
BHMT2
HGNC
Name
betaine--homocysteine S-methyltransferase 2
HGNC
NCBI Gene ID
23743
NCBI Gene
HGNC ID
HGNC:1048
HGNC
Ensembl
ENSG00000132840
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H2M3S-methylmethionine--homocysteine S-methyltransferase BHMT23630Ensembl, GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438978Q9H2M3Espacenet
JP 2025062604 A2025-04-149053Q9H2M3Espacenet
US 11446398 B22022-09-209053Q9H2M3Espacenet
JP 2022524081 A2022-04-27112024Q9H2M3Espacenet
JP 2019054813 A2019-04-11219413Q9H2M3Espacenet
WO 2017121974 A12017-07-206Q9H2M3Espacenet
JP 2017121241 A2017-07-13219413Q9H2M3Espacenet
US 9290773 B22016-03-228305Q9H2M3Espacenet
JP 2015516143 A2015-06-08219413Q9H2M3Espacenet
WO 2013190075 A22013-12-27889Q9H2M3Espacenet

1 to 10 of 13

See all 13 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BETAINECHEMBL95889Betaine-homocysteine S-methyltransferase substrateSUBSTRATE

Source ChEMBL

Trials14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07276204BETAINEPHASE2ClinicalTrials.gov
NCT06308367BETAINEPHASE2ClinicalTrials.gov
NCT05342272BETAINEPHASE3ClinicalTrials.gov
NCT02404337BETAINEPHASE2ClinicalTrials.gov
NCT02122211BETAINEPHASE1ClinicalTrials.gov
NCT01950039BETAINEPHASE22021-04-20ClinicalTrials.gov
NCT01838941BETAINEPHASE32016-06-28ClinicalTrials.gov
NCT01371357BETAINEPHASE3ClinicalTrials.gov
NCT00882193BETAINEEARLY_PHASE1ClinicalTrials.gov
NCT00586911BETAINEPHASE2ClinicalTrials.gov

1 to 10 of 14

See all 14 trials

NIH grants231

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBHMT2 papersNewest fiscal year
K12CA090433PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAM12025
P01AI089618Structure-function analysis of infection- and vaccine-induced B-cell repertoires12025
P20GM113226Hepatobiology and Toxicology COBRE12025
P30AG066507Johns Hopkins Alzheimer's Disease Research Center12025
P30AG072972UC Davis Alzheimer's Disease Research Center12025
P30CA006516Dana-Farber/Harvard Cancer Center12025
P30CA006973Regional Oncology Research Center12025
P30CA015704Cancer Center Support Grant12025
P30CA016087Cancer Center Support Grant12025
P30CA016359Cancer Center Support Grant12025

1 to 10 of 231Source NIH's project files

See all 231 nih grants

Papers213

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Biochemical characterization of a homocysteine S-methyltransferase from Leuconostoc suionicum.J Biochem202642720554PubTator, text miningPubMed
High-throughput single-cell DNA methylation and chromatin accessibility co-profiling with SpliCOOL-seq.Clin Transl Med202641603298PubTator, text miningPubMed
The BHMT2/MAT1A/AHSG axis promotes M1 macrophage activation and exacerbates necrotizing enterocolitis.Sci Rep202541219226PubTator, text miningPubMed
Identification of serum N,N-dimethylglycine as a potential biomarker for prenatal diagnosis of congenital heart disease using 1HNMR and UPLC-MS/MS metabonomics.Anal Bioanal Chem202540864205PubTator, text miningPubMed
Integrated ubiquitomics characterization of hepatocellular carcinomas.Hepatology202539348425PubTator, text miningPubMed
Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles.Genes (Basel)202439062651PubTator, text miningPubMed
Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics.Clin Proteomics202337940875PubTator, text miningPubMed
Correlation of the methylomic signature of smoking during pregnancy with clinical traits in ADHD.J Psychiatry Neurosci202337857414PubTator, text miningPubMed
Proteomics Profiling of Bladder Cancer Tissues from Early to Advanced Stages Reveals NNMT and GALK1 as Biomarkers for Early Detection and Prognosis of BCa.Int J Mol Sci202337834386PubTator, text miningPubMed
Bioinformatical analysis of the key differentially expressed genes for screening potential biomarkers in Wilms tumor.Sci Rep202337717078PubTator, text miningPubMed

1 to 10 of 213

See all 213 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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