Gene · 23743
BHMT2: betaine--homocysteine S-methyltransferase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BHMT2: betaine--homocysteine S-methyltransferase 2. Genes, record 23743. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23743
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H2M3 | S-methylmethionine--homocysteine S-methyltransferase BHMT2 | 363 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents13
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 38978 | Q9H2M3 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 9053 | Q9H2M3 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 9053 | Q9H2M3 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 112024 | Q9H2M3 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 219413 | Q9H2M3 | Espacenet |
| WO 2017121974 A1 | 2017-07-20 | 6 | Q9H2M3 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 219413 | Q9H2M3 | Espacenet |
| US 9290773 B2 | 2016-03-22 | 8305 | Q9H2M3 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 219413 | Q9H2M3 | Espacenet |
| WO 2013190075 A2 | 2013-12-27 | 889 | Q9H2M3 | Espacenet |
1 to 10 of 13
See all 13 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| BETAINE | CHEMBL95889 | Betaine-homocysteine S-methyltransferase substrate | SUBSTRATE |
Source ChEMBL
Trials14
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07276204 | BETAINE | PHASE2 | ClinicalTrials.gov | |
| NCT06308367 | BETAINE | PHASE2 | ClinicalTrials.gov | |
| NCT05342272 | BETAINE | PHASE3 | ClinicalTrials.gov | |
| NCT02404337 | BETAINE | PHASE2 | ClinicalTrials.gov | |
| NCT02122211 | BETAINE | PHASE1 | ClinicalTrials.gov | |
| NCT01950039 | BETAINE | PHASE2 | 2021-04-20 | ClinicalTrials.gov |
| NCT01838941 | BETAINE | PHASE3 | 2016-06-28 | ClinicalTrials.gov |
| NCT01371357 | BETAINE | PHASE3 | ClinicalTrials.gov | |
| NCT00882193 | BETAINE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT00586911 | BETAINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 14
See all 14 trialsNIH grants231
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BHMT2 papers | Newest fiscal year |
|---|---|---|---|
| K12CA090433 | PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAM | 1 | 2025 |
| P01AI089618 | Structure-function analysis of infection- and vaccine-induced B-cell repertoires | 1 | 2025 |
| P20GM113226 | Hepatobiology and Toxicology COBRE | 1 | 2025 |
| P30AG066507 | Johns Hopkins Alzheimer's Disease Research Center | 1 | 2025 |
| P30AG072972 | UC Davis Alzheimer's Disease Research Center | 1 | 2025 |
| P30CA006516 | Dana-Farber/Harvard Cancer Center | 1 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 1 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 1 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 1 | 2025 |
| P30CA016359 | Cancer Center Support Grant | 1 | 2025 |
1 to 10 of 231Source NIH's project files
See all 231 nih grantsPapers213
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Biochemical characterization of a homocysteine S-methyltransferase from Leuconostoc suionicum. | J Biochem | 2026 | 42720554 | PubTator, text mining | PubMed |
| High-throughput single-cell DNA methylation and chromatin accessibility co-profiling with SpliCOOL-seq. | Clin Transl Med | 2026 | 41603298 | PubTator, text mining | PubMed |
| The BHMT2/MAT1A/AHSG axis promotes M1 macrophage activation and exacerbates necrotizing enterocolitis. | Sci Rep | 2025 | 41219226 | PubTator, text mining | PubMed |
| Identification of serum N,N-dimethylglycine as a potential biomarker for prenatal diagnosis of congenital heart disease using 1HNMR and UPLC-MS/MS metabonomics. | Anal Bioanal Chem | 2025 | 40864205 | PubTator, text mining | PubMed |
| Integrated ubiquitomics characterization of hepatocellular carcinomas. | Hepatology | 2025 | 39348425 | PubTator, text mining | PubMed |
| Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles. | Genes (Basel) | 2024 | 39062651 | PubTator, text mining | PubMed |
| Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics. | Clin Proteomics | 2023 | 37940875 | PubTator, text mining | PubMed |
| Correlation of the methylomic signature of smoking during pregnancy with clinical traits in ADHD. | J Psychiatry Neurosci | 2023 | 37857414 | PubTator, text mining | PubMed |
| Proteomics Profiling of Bladder Cancer Tissues from Early to Advanced Stages Reveals NNMT and GALK1 as Biomarkers for Early Detection and Prognosis of BCa. | Int J Mol Sci | 2023 | 37834386 | PubTator, text mining | PubMed |
| Bioinformatical analysis of the key differentially expressed genes for screening potential biomarkers in Wilms tumor. | Sci Rep | 2023 | 37717078 | PubTator, text mining | PubMed |
1 to 10 of 213
See all 213 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23743
GET https://conductscience.org/api/genes/v1/23743/patents