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ALK: ALK receptor tyrosine kinase

1 protein, 115 patents, 20 drugs, 339 trials, 6,157 NIH grants and 34,371 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolALKHGNC
NameALK receptor tyrosine kinaseHGNC
NCBI Gene ID238NCBI Gene
HGNC IDHGNC:427HGNC
EnsemblENSG00000171094NCBI Gene
AliasesALK1, CD246, NBLST3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9UM73ALK tyrosine kinase receptor1,62079Ensembl, GeneID, HGNCUniProt

Patents 115

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026511570 A2026-04-1430Q9UM73Espacenet
EP 4704864 A22026-03-1132968Q9UM73Espacenet
EP 4704864 A22026-03-1133008Q9UM73Espacenet
EP 4684803 A12026-01-283Q9UM73Espacenet
EP 4670728 A12025-12-3130Q9UM73Espacenet
KR 1020250166953 A2025-11-2830Q9UM73Espacenet
EP 4650780 A22025-11-1910655Q9UM73Espacenet
EP 4641201 A22025-10-2911042Q9UM73Espacenet
JP 2025529142 A2025-09-04377Q9UM73Espacenet
US 12371689 B22025-07-29377Q9UM73Espacenet

Drugs 20

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALECTINIBCHEMBL1738797ALK tyrosine kinase receptor inhibitorINHIBITORChEMBL
ALECTINIBCHEMBL1738797EML4-ALK inhibitorINHIBITORChEMBL
ALECTINIB HYDROCHLORIDECHEMBL3707320ALK tyrosine kinase receptor inhibitorINHIBITORChEMBL
ALECTINIB HYDROCHLORIDECHEMBL3707320EML4-ALK inhibitorINHIBITORChEMBL
ASP-3026CHEMBL3545360ALK tyrosine kinase receptor inhibitorINHIBITORChEMBL
BRIGATINIBCHEMBL3545311ALK tyrosine kinase receptor inhibitorINHIBITORChEMBL
CEP-37440CHEMBL3951811ALK tyrosine kinase receptor inhibitorINHIBITORChEMBL
CERITINIBCHEMBL2403108ALK tyrosine kinase receptor inhibitorINHIBITORChEMBL
CERITINIBCHEMBL2403108EML4-ALK inhibitorINHIBITORChEMBL
CERITINIBCHEMBL2403108NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) inhibitorINHIBITORChEMBL

Trials 339

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07573696ALECTINIBPHASE2ClinicalTrials.gov
NCT07567352LORLATINIBClinicalTrials.gov
NCT07560410ALECTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07560410CRIZOTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07556549LORLATINIBClinicalTrials.gov
NCT07415005LORLATINIBPHASE2ClinicalTrials.gov
NCT07354061ENSARTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07235306ENSARTINIBPHASE2ClinicalTrials.gov
NCT07207278ALECTINIBClinicalTrials.gov
NCT07207278CRIZOTINIBClinicalTrials.gov

NIH grants 6157

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant6282,025NIH's project files
P30CA016672Cancer Center Support Grant3092,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant1002,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)972,025NIH's project files
R01CA164273Overcoming Resistance Mechanisms to Anaplastic Lymphoma Kinase Inhibitors642,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant602,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award542,025NIH's project files
P30CA006973Regional Oncology Research Center482,025NIH's project files
T32CA009207Investigational Cancer Therapeutics Training Program (ICTTP)482,025NIH's project files
P30CA047904Cancer Center Support Grant452,025NIH's project files

Papers 34371

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827359PubTator, text miningPubMed
42823962PubTator, text miningPubMed
42823821PubTator, text miningPubMed
42820355PubTator, text miningPubMed
42816387PubTator, text miningPubMed
42813170PubTator, text miningPubMed
42809935PubTator, text miningPubMed
42806342PubTator, text miningPubMed
42804986PubTator, text miningPubMed
42803850PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license