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ALOX12: arachidonate 12-lipoxygenase, 12S type
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Gene · 239

Papers2,360

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,360

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TitleJournalYearPMIDFound bySource
Screening of Programmed Cell Death-Related Biomarkers and Exploration of Mechanisms in Zhenwu Decoction for Treating Chronic Kidney Disease.Comb Chem High Throughput Screen202642817110PubTator, text miningPubMed
Divergent mechanistic reliance on the phosphatidylinositol 4-kinase (PI4K)/oxysterol-binding protein (OSBP) axis during Zika virus versus dengue virus and West Nile virus replication organelle biogenesis.
Virus Genes202642801443PubTator, text miningPubMed
Association of ALOX12-Mediated AA/12-HETE Metabolic Dysregulation with Abdominal Aortic Aneurysm Enlargement and Dissection.J Cardiovasc Dev Dis202642783047PubTator, text miningPubMed
8-Iso-Prostaglandin F2α and Lipoxygenase Gene Expression as Candidate Molecular Markers of Training Adaptation in Professional Volleyball Players: A Pilot Study.Int J Mol Sci202642653109PubTator, text miningPubMed
High-Density Co-Based Single-Atom Nanozymes Alleviate Myocardial Ischemia-Reperfusion Injury by Disrupting the Cycle of Oxidative Stress-Ferroptosis-Inflammatory Response.Angew Chem Int Ed Engl202642599808PubTator, text miningPubMed
ALOX12 suppresses colon cancer progression by promoting p53-mediated ferroptosis through upregulating ROS-induced stress.Transl Cancer Res202642591750PubTator, text miningPubMed
Metabolic and Oxylipin Signature of Testicular Germ Cell Tumors in Seminal Plasma.Andrology202642572366PubTator, text miningPubMed
Repetin Regulates Epidermal Barrier Homeostasis and Is Associated With Inflammatory Skin Diseases.Exp Dermatol202642544840PubTator, text miningPubMed
Ferroptosis-associated ALOX12 suppresses ovarian cancer progression through MAPK signaling pathway.Tissue Cell202642526085PubTator, text miningPubMed
Lipid peroxidation impacts orthoflavivirus infection in a virus-dependent manner.Cell Death Dis202642420242PubTator, text miningPubMed
Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis.J Lipid Res202642372877PubTator, text miningPubMed
Reactivity of mammalian lipoxygenases (ALOX isoforms) with phospholipids, biomembranes and lipoproteins.Commun Biol202642260098PubTator, text miningPubMed
Tumour-associated high endothelial venules drive portal-specific immune evasion in lymph nodes via ALOX12.Nat Commun202642115618PubTator, text miningPubMed
ATF3 links endoplasmic reticulum stress to ferroptosis via transcriptional activation of ALOX12 in benzene-induced hematotoxicity.Ecotoxicol Environ Saf202641966022PubTator, text miningPubMed
VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia.Blood Vessel Thromb Hemost202641909515PubTator, text miningPubMed
Inhibition of endothelial ALOX12 mitigates cerebral ischemia-reperfusion injury by suppressing 12-HETE.Free Radic Biol Med202641887376PubTator, text miningPubMed
Maternal 12-HETE is associated with childhood asthma and the responses to prenatal omega-3 supplementation.Cell Rep Med202641850235PubTator, text miningPubMed
Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target.Mol Biomed202641795043PubTator, text miningPubMed
Regulatory roles of bioactive lipids in vascular homeostasis and remodeling.Med Rev (2021)202641783891PubTator, text miningPubMed
Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches.Mol Biomed202641772328PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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