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Gene · 239

ALOX12: arachidonate 12-lipoxygenase, 12S type

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ALOX12: arachidonate 12-lipoxygenase, 12S type. Genes, record 239. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/239

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Gene

Symbol
ALOX12
HGNC
Name
arachidonate 12-lipoxygenase, 12S type
HGNC
NCBI Gene ID
239
NCBI Gene
HGNC ID
HGNC:429
HGNC
Ensembl
ENSG00000108839
NCBI Gene
Aliases
12-LOX, 12S-LOX, LOG12
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18054Polyunsaturated fatty acid lipoxygenase ALOX126635Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437774P18054Espacenet
EP 4641201 A22025-10-29975P18054Espacenet
JP 2025517969 A2025-06-12975P18054Espacenet
JP 2025062604 A2025-04-145986P18054Espacenet
US 11446398 B22022-09-205986P18054Espacenet
US 11319510 B22022-05-0327P18054Espacenet
JP 2022524081 A2022-04-27108957P18054Espacenet
US 11078247 B22021-08-03465P18054Espacenet
US 11072764 B22021-07-279P18054Espacenet
US 11041209 B22021-06-221499P18054Espacenet

1 to 10 of 46

See all 46 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BENOXAPROFENCHEMBL340978Arachidonate 12-lipoxygenase inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,363

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleALOX12 papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30DK097512Indiana Diabetes Research Center82025
R01DK060581Transcriptional and Translational Mechanisms Governing Beta Cell Function82025
P30CA008748Cancer Center Support Grant72025
P30DK020595Diabetes Research and Training Center72025
P30CA068485Cancer Center Support Grant52025
R01DK090490Role of lipid droplet proteins in islet function in diabetes and obesity52025
P30CA010815Consolidated Basic Cancer Research Program42025
P30DK072476Pennington/Louisiana NORC42025
T32CA009171Training Program in Basic Cancer Research42025

1 to 10 of 1,363Source NIH's project files

See all 1,363 nih grants

Papers2,360

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Screening of Programmed Cell Death-Related Biomarkers and Exploration of Mechanisms in Zhenwu Decoction for Treating Chronic Kidney Disease.Comb Chem High Throughput Screen202642817110PubTator, text miningPubMed
Divergent mechanistic reliance on the phosphatidylinositol 4-kinase (PI4K)/oxysterol-binding protein (OSBP) axis during Zika virus versus dengue virus and West Nile virus replication organelle biogenesis.
Virus Genes202642801443PubTator, text miningPubMed
Association of ALOX12-Mediated AA/12-HETE Metabolic Dysregulation with Abdominal Aortic Aneurysm Enlargement and Dissection.J Cardiovasc Dev Dis202642783047PubTator, text miningPubMed
8-Iso-Prostaglandin F2α and Lipoxygenase Gene Expression as Candidate Molecular Markers of Training Adaptation in Professional Volleyball Players: A Pilot Study.Int J Mol Sci202642653109PubTator, text miningPubMed
High-Density Co-Based Single-Atom Nanozymes Alleviate Myocardial Ischemia-Reperfusion Injury by Disrupting the Cycle of Oxidative Stress-Ferroptosis-Inflammatory Response.Angew Chem Int Ed Engl202642599808PubTator, text miningPubMed
ALOX12 suppresses colon cancer progression by promoting p53-mediated ferroptosis through upregulating ROS-induced stress.Transl Cancer Res202642591750PubTator, text miningPubMed
Metabolic and Oxylipin Signature of Testicular Germ Cell Tumors in Seminal Plasma.Andrology202642572366PubTator, text miningPubMed
Repetin Regulates Epidermal Barrier Homeostasis and Is Associated With Inflammatory Skin Diseases.Exp Dermatol202642544840PubTator, text miningPubMed
Ferroptosis-associated ALOX12 suppresses ovarian cancer progression through MAPK signaling pathway.Tissue Cell202642526085PubTator, text miningPubMed
Lipid peroxidation impacts orthoflavivirus infection in a virus-dependent manner.Cell Death Dis202642420242PubTator, text miningPubMed

1 to 10 of 2,360

See all 2,360 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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