Gene · 239
ALOX12: arachidonate 12-lipoxygenase, 12S type
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ALOX12: arachidonate 12-lipoxygenase, 12S type. Genes, record 239. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/239
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P18054 | Polyunsaturated fatty acid lipoxygenase ALOX12 | 663 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37774 | P18054 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 975 | P18054 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 975 | P18054 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 5986 | P18054 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 5986 | P18054 | Espacenet |
| US 11319510 B2 | 2022-05-03 | 27 | P18054 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 108957 | P18054 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 465 | P18054 | Espacenet |
| US 11072764 B2 | 2021-07-27 | 9 | P18054 | Espacenet |
| US 11041209 B2 | 2021-06-22 | 1499 | P18054 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| BENOXAPROFEN | CHEMBL340978 | Arachidonate 12-lipoxygenase inhibitor | INHIBITOR |
Source ChEMBL
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,363
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ALOX12 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P30DK097512 | Indiana Diabetes Research Center | 8 | 2025 |
| R01DK060581 | Transcriptional and Translational Mechanisms Governing Beta Cell Function | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30DK020595 | Diabetes Research and Training Center | 7 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| R01DK090490 | Role of lipid droplet proteins in islet function in diabetes and obesity | 5 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 4 | 2025 |
| P30DK072476 | Pennington/Louisiana NORC | 4 | 2025 |
| T32CA009171 | Training Program in Basic Cancer Research | 4 | 2025 |
1 to 10 of 1,363Source NIH's project files
See all 1,363 nih grantsPapers2,360
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Screening of Programmed Cell Death-Related Biomarkers and Exploration of Mechanisms in Zhenwu Decoction for Treating Chronic Kidney Disease. | Comb Chem High Throughput Screen | 2026 | 42817110 | PubTator, text mining | PubMed |
Divergent mechanistic reliance on the phosphatidylinositol 4-kinase (PI4K)/oxysterol-binding protein (OSBP) axis during Zika virus versus dengue virus and West Nile virus replication organelle biogenesis. | Virus Genes | 2026 | 42801443 | PubTator, text mining | PubMed |
| Association of ALOX12-Mediated AA/12-HETE Metabolic Dysregulation with Abdominal Aortic Aneurysm Enlargement and Dissection. | J Cardiovasc Dev Dis | 2026 | 42783047 | PubTator, text mining | PubMed |
| 8-Iso-Prostaglandin F2α and Lipoxygenase Gene Expression as Candidate Molecular Markers of Training Adaptation in Professional Volleyball Players: A Pilot Study. | Int J Mol Sci | 2026 | 42653109 | PubTator, text mining | PubMed |
| High-Density Co-Based Single-Atom Nanozymes Alleviate Myocardial Ischemia-Reperfusion Injury by Disrupting the Cycle of Oxidative Stress-Ferroptosis-Inflammatory Response. | Angew Chem Int Ed Engl | 2026 | 42599808 | PubTator, text mining | PubMed |
| ALOX12 suppresses colon cancer progression by promoting p53-mediated ferroptosis through upregulating ROS-induced stress. | Transl Cancer Res | 2026 | 42591750 | PubTator, text mining | PubMed |
| Metabolic and Oxylipin Signature of Testicular Germ Cell Tumors in Seminal Plasma. | Andrology | 2026 | 42572366 | PubTator, text mining | PubMed |
| Repetin Regulates Epidermal Barrier Homeostasis and Is Associated With Inflammatory Skin Diseases. | Exp Dermatol | 2026 | 42544840 | PubTator, text mining | PubMed |
| Ferroptosis-associated ALOX12 suppresses ovarian cancer progression through MAPK signaling pathway. | Tissue Cell | 2026 | 42526085 | PubTator, text mining | PubMed |
| Lipid peroxidation impacts orthoflavivirus infection in a virus-dependent manner. | Cell Death Dis | 2026 | 42420242 | PubTator, text mining | PubMed |
1 to 10 of 2,360
See all 2,360 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/239
GET https://conductscience.org/api/genes/v1/239/patents?page=2