Gene · 2395
FXN: frataxin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FXN: frataxin. Genes, record 2395. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2395
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16595 | Frataxin, mitochondrial | 210 | 19 | Ensembl, GeneID, HGNC |
Source UniProt
Patents125
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026151888 A1 | 2026-07-16 | 2 | Q16595 | Espacenet |
| JP 2026108757 A | 2026-06-30 | 1 | Q16595 | Espacenet |
| WO 2026017965 A1 | 2026-01-22 | 2 | Q16595 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 46693 | Q16595 | Espacenet |
| EP 4661917 A1 | 2025-12-17 | 15 | Q16595 | Espacenet |
| JP 2025179046 A | 2025-12-09 | 1725 | Q16595 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 14302 | Q16595 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5613 | Q16595 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5614 | Q16595 | Espacenet |
| EP 4611766 A1 | 2025-09-10 | 1 | Q16595 | Espacenet |
1 to 10 of 125
See all 125 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,467
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FXN papers | Newest fiscal year |
|---|---|---|---|
| P30ES013508 | Center of Excellence in Environmental Toxicology | 19 | 2025 |
| ZIAHD008814 | Mammalian iron-sulfur cluster biogenesis | 18 | 2025 |
| ZIAHD001602 | Regulation Of Intracellular Iron Metabolism | 11 | 2025 |
| ZIADK057602 | The consequences of the unusual mutation responsible for the Repeat Expansion Diseases | 9 | 2025 |
| R35GM118103 | Recognition of Cellular Targets by single and double-stranded nucleic acids | 8 | 2025 |
| R01NS072248 | Genome Studies in Hereditary Spastic Paraplegia- Beyond the Exome | 7 | 2025 |
| R01NS121038 | Defining the impact of Frataxin point mutations on Friedreich's ataxia pathogenesis | 6 | 2025 |
| R35GM130322 | Mechanisms of Genome Instability Mediated by Simple DNA Repeats | 6 | 2025 |
| T32ES019851 | Translational Research Training Program in Environmental Health Sciences | 6 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 5 | 2025 |
1 to 10 of 1,467Source NIH's project files
See all 1,467 nih grantsPapers2,919
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Calcium dysregulation amplifies fibrotic responses to TGFβ in human Friedreich's ataxia fibroblasts. | bioRxiv | 2026 | 42818031 | PubTator, text mining | PubMed |
| Large-scale genetic profiling of hereditary ataxias in China: implications for a stepwise molecular diagnostic strategy. | Transl Neurodegener | 2026 | 42806408 | PubTator, text mining | PubMed |
| Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework. | Int J Mol Sci | 2026 | 42794697 | PubTator, text mining | PubMed |
| Friedreich Ataxia: From Genetics to Mechanism to Clinical Features. | Annu Rev Pathol | 2026 | 42754241 | PubTator, text mining | PubMed |
| Serial assessment of echocardiographic measures in Friedreich ataxia. | Am Heart J Plus | 2026 | 42733758 | PubTator, text mining | PubMed |
| Ferroptosis, immune activation and MASH-related HCC. | Gut | 2026 | 42722415 | PubTator, text mining | PubMed |
| Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron-binding ridge. | FEBS J | 2026 | 42593048 | PubTator, text mining | PubMed |
| BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin. | Nat Cell Biol | 2026 | 42557413 | PubTator, text mining | PubMed |
| Multi-omics Mendelian randomization integrating GWAS, eQTL, mQTL and pQTL data prioritizes mitochondrial gene FXN as a hypothesis-generating candidate for nephrolithiasis. | Front Immunol | 2026 | 42548648 | PubTator, text mining | PubMed |
| Evolution of Friedreich's Ataxia Management Across Established and Emerging Therapies-Systematic Review and Meta-Analysis. | J Clin Med | 2026 | 42513621 | PubTator, text mining | PubMed |
1 to 10 of 2,919
See all 2,919 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2395
GET https://conductscience.org/api/genes/v1/2395/patents?page=2