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Gene · 2395

FXN: frataxin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FXN: frataxin. Genes, record 2395. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2395

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Gene

Symbol
FXN
HGNC
Name
frataxin
HGNC
NCBI Gene ID
2395
NCBI Gene
HGNC ID
HGNC:3951
HGNC
Ensembl
ENSG00000165060
NCBI Gene
Aliases
CyaY, FA, FARR, FRDA, X25
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16595Frataxin, mitochondrial21019Ensembl, GeneID, HGNC

Source UniProt

Patents125

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026151888 A12026-07-162Q16595Espacenet
JP 2026108757 A2026-06-301Q16595Espacenet
WO 2026017965 A12026-01-222Q16595Espacenet
JP 2026004568 A2026-01-1446693Q16595Espacenet
EP 4661917 A12025-12-1715Q16595Espacenet
JP 2025179046 A2025-12-091725Q16595Espacenet
EP 4650780 A22025-11-1914302Q16595Espacenet
JP 2025147176 A2025-10-065613Q16595Espacenet
JP 2025147176 A2025-10-065614Q16595Espacenet
EP 4611766 A12025-09-101Q16595Espacenet

1 to 10 of 125

See all 125 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,467

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFXN papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology192025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis182025
ZIAHD001602Regulation Of Intracellular Iron Metabolism112025
ZIADK057602The consequences of the unusual mutation responsible for the Repeat Expansion Diseases92025
R35GM118103Recognition of Cellular Targets by single and double-stranded nucleic acids82025
R01NS072248Genome Studies in Hereditary Spastic Paraplegia- Beyond the Exome72025
R01NS121038Defining the impact of Frataxin point mutations on Friedreich's ataxia pathogenesis62025
R35GM130322Mechanisms of Genome Instability Mediated by Simple DNA Repeats62025
T32ES019851Translational Research Training Program in Environmental Health Sciences62025
P01CA092584Structural Cell Biology of DNA Repair Machines52025

1 to 10 of 1,467Source NIH's project files

See all 1,467 nih grants

Papers2,919

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Calcium dysregulation amplifies fibrotic responses to TGFβ in human Friedreich's ataxia fibroblasts.bioRxiv202642818031PubTator, text miningPubMed
Large-scale genetic profiling of hereditary ataxias in China: implications for a stepwise molecular diagnostic strategy.Transl Neurodegener202642806408PubTator, text miningPubMed
Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework.Int J Mol Sci202642794697PubTator, text miningPubMed
Friedreich Ataxia: From Genetics to Mechanism to Clinical Features.Annu Rev Pathol202642754241PubTator, text miningPubMed
Serial assessment of echocardiographic measures in Friedreich ataxia.Am Heart J Plus202642733758PubTator, text miningPubMed
Ferroptosis, immune activation and MASH-related HCC.Gut202642722415PubTator, text miningPubMed
Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron-binding ridge.FEBS J202642593048PubTator, text miningPubMed
BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin.Nat Cell Biol202642557413PubTator, text miningPubMed
Multi-omics Mendelian randomization integrating GWAS, eQTL, mQTL and pQTL data prioritizes mitochondrial gene FXN as a hypothesis-generating candidate for nephrolithiasis.Front Immunol202642548648PubTator, text miningPubMed
Evolution of Friedreich's Ataxia Management Across Established and Emerging Therapies-Systematic Review and Meta-Analysis.J Clin Med202642513621PubTator, text miningPubMed

1 to 10 of 2,919

See all 2,919 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2395

GET https://conductscience.org/api/genes/v1/2395/patents?page=2