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ALOX5: arachidonate 5-lipoxygenase

1 protein, 61 patents, 11 drugs, 157 trials, 3,976 NIH grants and 11,077 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolALOX5HGNC
Namearachidonate 5-lipoxygenaseHGNC
NCBI Gene ID240NCBI Gene
HGNC IDHGNC:435HGNC
EnsemblENSG00000012779NCBI Gene
Aliases5-LO, 5-LOX, 5LPG, LOG5NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P09917Polyunsaturated fatty acid 5-lipoxygenase6749Ensembl, GeneID, HGNCUniProt

Patents 61

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-299712P09917Espacenet
JP 2025517969 A2025-06-129712P09917Espacenet
JP 2025062604 A2025-04-145998P09917Espacenet
JP 2025062604 A2025-04-146003P09917Espacenet
JP 2025032204 A2025-03-1124421P09917Espacenet
JP 2025032204 A2025-03-1124424P09917Espacenet
WO 2024252368 A22024-12-12145P09917Espacenet
EP 4461818 A22024-11-1324421P09917Espacenet
EP 4461818 A22024-11-1324424P09917Espacenet
JP 2024123008 A2024-09-104883P09917Espacenet

Drugs 11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATRELEUTONCHEMBL59356Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL
BALSALAZIDECHEMBL1201346Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL
BALSALAZIDE DISODIUMCHEMBL1200760Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL
MECLOFENAMATE SODIUMCHEMBL1562610Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL
MECLOFENAMIC ACIDCHEMBL509Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL
MESALAMINECHEMBL704Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL
OLSALAZINECHEMBL425Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL
OLSALAZINE SODIUMCHEMBL1201013Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL
PF-4191834CHEMBL4297416Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL
SULFASALAZINECHEMBL421Arachidonate 5-lipoxygenase inhibitorINHIBITORChEMBL

Trials 157

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07389824MESALAMINEClinicalTrials.gov
NCT07333716MESALAMINEPHASE2ClinicalTrials.gov
NCT07248644MESALAMINEPHASE4ClinicalTrials.gov
NCT07180186MESALAMINEClinicalTrials.gov
NCT06998693MESALAMINEClinicalTrials.gov
NCT06985134SULFASALAZINEPHASE3ClinicalTrials.gov
NCT06568224MESALAMINEClinicalTrials.gov
NCT06525974MESALAMINEEARLY_PHASE1ClinicalTrials.gov
NCT06360068SULFASALAZINEPHASE2ClinicalTrials.gov
NCT06293378SULFASALAZINEClinicalTrials.gov

NIH grants 3976

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant262,025NIH's project files
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease212,025NIH's project files
P30CA008748Cancer Center Support Grant172,025NIH's project files
R01AI078908Control of Pulmonary Inflammation by Leukotriene E4162,025NIH's project files
T32AI007306Immunologic Basis of Resistance and Hypersensitivity152,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)102,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology92,025NIH's project files
R01AI136041Eicosanoid Networks in Aspirin Hypersensitivity82,025NIH's project files
T32HL007633Integrated Training in Respiratory Research72,025NIH's project files
T32HL007749Multidisciplinary Training Program in Lung Disease72,025NIH's project files

Papers 11077

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42804920PubTator, text miningPubMed
42799005PubTator, text miningPubMed
42792810PubTator, text miningPubMed
42786864PubTator, text miningPubMed
42781302PubTator, text miningPubMed
42763661PubTator, text miningPubMed
42756334PubTator, text miningPubMed
42752769PubTator, text miningPubMed
42751055PubTator, text miningPubMed
42749385PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license