Gene · 241
ALOX5AP: arachidonate 5-lipoxygenase activating protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ALOX5AP: arachidonate 5-lipoxygenase activating protein. Genes, record 241. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/241
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P20292 | Arachidonate 5-lipoxygenase-activating protein | 161 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents59
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37779 | P20292 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 590 | P20292 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 378 | P20292 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 378 | P20292 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 6004 | P20292 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 590 | P20292 | Espacenet |
| WO 2024252368 A2 | 2024-12-12 | 205 | P20292 | Espacenet |
| US 12023385 B2 | 2024-07-02 | 34 | P20292 | Espacenet |
| EP 4119552 A1 | 2023-01-18 | 48 | P20292 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 6004 | P20292 | Espacenet |
1 to 10 of 59
See all 59 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials9
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07079761 | FIBOFLAPON SODIUM | PHASE2 | ClinicalTrials.gov | |
| NCT01471665 | FIBOFLAPON | PHASE2 | ClinicalTrials.gov | |
| NCT01286844 | FIBOFLAPON | PHASE2 | ClinicalTrials.gov | |
| NCT01156792 | FIBOFLAPON | PHASE2 | 2017-02-03 | ClinicalTrials.gov |
| NCT01147744 | FIBOFLAPON | PHASE2 | 2017-09-06 | ClinicalTrials.gov |
| NCT00850642 | FIBOFLAPON | PHASE2 | 2018-03-01 | ClinicalTrials.gov |
| NCT00812929 | FIBOFLAPON | PHASE2 | 2017-09-19 | ClinicalTrials.gov |
| NCT00812773 | FIBOFLAPON | PHASE2 | ClinicalTrials.gov | |
| NCT00748306 | FIBOFLAPON | PHASE2 | ClinicalTrials.gov |
NIH grants1,513
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ALOX5AP papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 6 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 4 | 2025 |
| U19AI095219 | Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease | 4 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 3 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 3 | 2025 |
| R01AI136041 | Eicosanoid Networks in Aspirin Hypersensitivity | 3 | 2025 |
| R01NS017950 | Precursors of Stroke Incidence and Prognosis | 3 | 2025 |
1 to 10 of 1,513Source NIH's project files
See all 1,513 nih grantsPapers2,196
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Construction of multivalent aptamer-based fluorogenic DNA nanostructures for label-free fluorescent biosensors. | Talanta | 2027 | 42685561 | PubTator, text mining | PubMed |
| The 5-Lipoxygenase Pathway in Ovarian Cancer: Mechanisms of Metastasis, Chemoresistance, and Translational Targeting. | Int J Womens Health | 2026 | 42763661 | PubTator, text mining | PubMed |
| Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps Associated with Allergic Sensitization. | Int J Mol Sci | 2026 | 42737845 | PubTator, text mining | PubMed |
| Identifying JAK2 and ANXA5 as Key Genes Linking Obstructive Sleep Apnea and Oxidative Stress via Machine Learning and Multilayer Transcriptomic Integration With Functional Validation. | FASEB J | 2026 | 42730994 | PubTator, text mining | PubMed |
| Integrated Immunological Analysis of Interactions Between CXCL13+ T Cells and LAMP3+ DC in the Immunotherapy Response of Bladder Cancer. | Mol Carcinog | 2026 | 42555166 | PubTator, text mining | PubMed |
| Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation. | Acta Neuropathol | 2026 | 42550249 | PubTator, text mining | PubMed |
| A Functional Variant of CYP4V2 Contributes to Asthma Susceptibility Through Methylation-Mediated Regulation of the Arachidonic Acid Pathway. | J Asthma Allergy | 2026 | 42540736 | PubTator, text mining | PubMed |
| Multi-omic profiling identifies TREM2+ lipid-laden macrophages as inflammatory drivers and therapeutic targets of colorectal cancer liver metastasis. | Cancer Lett | 2026 | 42250756 | PubTator, text mining | PubMed |
| Dual biomarkers ALOX5AP and INPP4A are associated with lipid metabolism and neutrophil extracellular traps in periodontitis: A bioinformatics and clinical validation study. | Arch Oral Biol | 2026 | 41962331 | PubTator, text mining | PubMed |
| Canopy Flap: A Specially Shaped Flap for the Repair of Complex Hand Defects. | Orthopedics | 2026 | 41944656 | PubTator, text mining | PubMed |
1 to 10 of 2,196
See all 2,196 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/241
GET https://conductscience.org/api/genes/v1/241/patents?page=2