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ALOX5AP: arachidonate 5-lipoxygenase activating protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ALOX5AP: arachidonate 5-lipoxygenase activating protein. Genes, record 241. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/241

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Gene

Symbol
ALOX5AP
HGNC
Name
arachidonate 5-lipoxygenase activating protein
HGNC
NCBI Gene ID
241
NCBI Gene
HGNC ID
HGNC:436
HGNC
Ensembl
ENSG00000132965
NCBI Gene
Aliases
FLAP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20292Arachidonate 5-lipoxygenase-activating protein1614Ensembl, GeneID, HGNC

Source UniProt

Patents59

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437779P20292Espacenet
EP 4641202 A22025-10-29590P20292Espacenet
JP 2025529142 A2025-09-04378P20292Espacenet
US 12371689 B22025-07-29378P20292Espacenet
JP 2025062604 A2025-04-146004P20292Espacenet
KR 1020250017231 A2025-02-04590P20292Espacenet
WO 2024252368 A22024-12-12205P20292Espacenet
US 12023385 B22024-07-0234P20292Espacenet
EP 4119552 A12023-01-1848P20292Espacenet
US 11446398 B22022-09-206004P20292Espacenet

1 to 10 of 59

See all 59 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FIBOFLAPONCHEMBL19226605-lipoxygenase activating protein inhibitorINHIBITORChEMBL
FIBOFLAPON SODIUMCHEMBL19226735-lipoxygenase activating protein inhibitorINHIBITORChEMBL
VELIFLAPONCHEMBL887125-lipoxygenase activating protein inhibitorINHIBITORChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07079761FIBOFLAPON SODIUMPHASE2ClinicalTrials.gov
NCT01471665FIBOFLAPONPHASE2ClinicalTrials.gov
NCT01286844FIBOFLAPONPHASE2ClinicalTrials.gov
NCT01156792FIBOFLAPONPHASE22017-02-03ClinicalTrials.gov
NCT01147744FIBOFLAPONPHASE22017-09-06ClinicalTrials.gov
NCT00850642FIBOFLAPONPHASE22018-03-01ClinicalTrials.gov
NCT00812929FIBOFLAPONPHASE22017-09-19ClinicalTrials.gov
NCT00812773FIBOFLAPONPHASE2ClinicalTrials.gov
NCT00748306FIBOFLAPONPHASE2ClinicalTrials.gov

NIH grants1,513

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleALOX5AP papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30CA008748Cancer Center Support Grant72025
P30ES013508Center of Excellence in Environmental Toxicology62025
P30CA068485Cancer Center Support Grant42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease42025
P30CA013696Cancer Center Support Grant32025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease32025
R01AI136041Eicosanoid Networks in Aspirin Hypersensitivity32025
R01NS017950Precursors of Stroke Incidence and Prognosis32025

1 to 10 of 1,513Source NIH's project files

See all 1,513 nih grants

Papers2,196

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Construction of multivalent aptamer-based fluorogenic DNA nanostructures for label-free fluorescent biosensors.Talanta202742685561PubTator, text miningPubMed
The 5-Lipoxygenase Pathway in Ovarian Cancer: Mechanisms of Metastasis, Chemoresistance, and Translational Targeting.Int J Womens Health202642763661PubTator, text miningPubMed
Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps Associated with Allergic Sensitization.Int J Mol Sci202642737845PubTator, text miningPubMed
Identifying JAK2 and ANXA5 as Key Genes Linking Obstructive Sleep Apnea and Oxidative Stress via Machine Learning and Multilayer Transcriptomic Integration With Functional Validation.FASEB J202642730994PubTator, text miningPubMed
Integrated Immunological Analysis of Interactions Between CXCL13+ T Cells and LAMP3+ DC in the Immunotherapy Response of Bladder Cancer.Mol Carcinog202642555166PubTator, text miningPubMed
Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation.Acta Neuropathol202642550249PubTator, text miningPubMed
A Functional Variant of CYP4V2 Contributes to Asthma Susceptibility Through Methylation-Mediated Regulation of the Arachidonic Acid Pathway.J Asthma Allergy202642540736PubTator, text miningPubMed
Multi-omic profiling identifies TREM2+ lipid-laden macrophages as inflammatory drivers and therapeutic targets of colorectal cancer liver metastasis.Cancer Lett202642250756PubTator, text miningPubMed
Dual biomarkers ALOX5AP and INPP4A are associated with lipid metabolism and neutrophil extracellular traps in periodontitis: A bioinformatics and clinical validation study.Arch Oral Biol202641962331PubTator, text miningPubMed
Canopy Flap: A Specially Shaped Flap for the Repair of Complex Hand Defects.Orthopedics202641944656PubTator, text miningPubMed

1 to 10 of 2,196

See all 2,196 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/241

GET https://conductscience.org/api/genes/v1/241/patents?page=2