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Gene · 24145

PANX1: pannexin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PANX1: pannexin 1. Genes, record 24145. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/24145

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Gene

Symbol
PANX1
HGNC
Name
pannexin 1
HGNC
NCBI Gene ID
24145
NCBI Gene
HGNC ID
HGNC:8599
HGNC
Ensembl
ENSG00000110218
NCBI Gene
Aliases
MRS1, OOMD7, OZEMA7, PX1, UNQ2529
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96RD7Pannexin-142633Ensembl, GeneID, HGNC

Source UniProt

Patents187

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026088213 A2026-05-2888Q96RD7Espacenet
EP 4650780 A22025-11-19687Q96RD7Espacenet
EP 4640849 A22025-10-2982Q96RD7Espacenet
EP 4641201 A22025-10-29481Q96RD7Espacenet
JP 2025529142 A2025-09-043334Q96RD7Espacenet
US 12371689 B22025-07-293334Q96RD7Espacenet
JP 2025519096 A2025-06-2482Q96RD7Espacenet
JP 2025517969 A2025-06-12481Q96RD7Espacenet
JP 2025517970 A2025-06-12687Q96RD7Espacenet
JP 2023512587 A2023-03-2779Q96RD7Espacenet

1 to 10 of 187

See all 187 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,454

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePANX1 papersNewest fiscal year
R01HL137112Purinergic Regulation of Veinous Endothelial Permeability112025
T32HL007284Basic Cardiovascular Research Training Grant112025
P40OD010440Caenorhabditis Genetics Center82025
P30EY014801Miami Center for Vision Research72025
R01GM114379Structure and Function of Pannexins: Activation Mechanism72025
ZIAHD000195Intracellular Signaling In Endocrine Cells72025
P30EY001583P30 Core Grant For Vision Research42025
R01DK103723Regulation of enteric motor neurocircuits by enteric glia in health and disease42025
R01HL142808Paracrine TNF signaling impairs endothelial TRPV4 microdomains in obesity42025
R01HL146914Flow-Activated Calcium Signaling Microdomains in Small Pulmonary Arteries42025

1 to 10 of 1,454Source NIH's project files

See all 1,454 nih grants

Papers2,465

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Role of liver connexins and pannexins in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) in the context of overnutrition: A narrative review.Mol Cell Endocrinol202742648696PubTator, text miningPubMed
Pannexin1 promotes cellular senescence by triggering mtDNA release to activate the cGAS-STING pathway.Biochim Biophys Acta Mol Basis Dis202742521040PubTator, text miningPubMed
Immunohistochemical and bioinformatic analysis of pannexin-1 expression in cutaneous basal and cutaneous squamous cell carcinomas.Open Med (Wars)202642820025PubTator, text miningPubMed
Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.Front Cell Neurosci202642819782PubTator, text miningPubMed
Targeting vascular inflammation and endothelial dysfunction with nanobodies: emerging therapeutic strategies for cardiovascular disease.Front Immunol202642812766PubTator, text miningPubMed
Pannexin 1 beyond the plasma membrane in neuroinflammation: An organelle-centered perspective and therapeutic opportunities.Pharmacol Res202642790832PubTator, text miningPubMed
Developmental synchrony of retinal waves, apoptosis, and angiogenesis in postnatal retina.Elife202642781866PubTator, text miningPubMed
Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes.J Cachexia Sarcopenia Muscle202642773997PubTator, text miningPubMed
Gap junctions and hemichannels in cancer: A "Wired versus Broadcast" framework for tumor microenvironment routing of cGAMP-STING signals and therapy response.Transl Oncol202642743660PubTator, text miningPubMed
SIV/HIV Induces Arachidonic Acid-Mediated Inflammation in the Heart by a Pannexin-1 Mechanism.Am J Pathol202642665161PubTator, text miningPubMed

1 to 10 of 2,465

See all 2,465 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/24145

GET https://conductscience.org/api/genes/v1/24145/patents?page=2