Gene · 24145
PANX1: pannexin 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PANX1: pannexin 1. Genes, record 24145. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/24145
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96RD7 | Pannexin-1 | 426 | 33 | Ensembl, GeneID, HGNC |
Source UniProt
Patents187
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026088213 A | 2026-05-28 | 88 | Q96RD7 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 687 | Q96RD7 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 82 | Q96RD7 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 481 | Q96RD7 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3334 | Q96RD7 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3334 | Q96RD7 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 82 | Q96RD7 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 481 | Q96RD7 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 687 | Q96RD7 | Espacenet |
| JP 2023512587 A | 2023-03-27 | 79 | Q96RD7 | Espacenet |
1 to 10 of 187
See all 187 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,454
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PANX1 papers | Newest fiscal year |
|---|---|---|---|
| R01HL137112 | Purinergic Regulation of Veinous Endothelial Permeability | 11 | 2025 |
| T32HL007284 | Basic Cardiovascular Research Training Grant | 11 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 8 | 2025 |
| P30EY014801 | Miami Center for Vision Research | 7 | 2025 |
| R01GM114379 | Structure and Function of Pannexins: Activation Mechanism | 7 | 2025 |
| ZIAHD000195 | Intracellular Signaling In Endocrine Cells | 7 | 2025 |
| P30EY001583 | P30 Core Grant For Vision Research | 4 | 2025 |
| R01DK103723 | Regulation of enteric motor neurocircuits by enteric glia in health and disease | 4 | 2025 |
| R01HL142808 | Paracrine TNF signaling impairs endothelial TRPV4 microdomains in obesity | 4 | 2025 |
| R01HL146914 | Flow-Activated Calcium Signaling Microdomains in Small Pulmonary Arteries | 4 | 2025 |
1 to 10 of 1,454Source NIH's project files
See all 1,454 nih grantsPapers2,465
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Role of liver connexins and pannexins in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) in the context of overnutrition: A narrative review. | Mol Cell Endocrinol | 2027 | 42648696 | PubTator, text mining | PubMed |
| Pannexin1 promotes cellular senescence by triggering mtDNA release to activate the cGAS-STING pathway. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42521040 | PubTator, text mining | PubMed |
| Immunohistochemical and bioinformatic analysis of pannexin-1 expression in cutaneous basal and cutaneous squamous cell carcinomas. | Open Med (Wars) | 2026 | 42820025 | PubTator, text mining | PubMed |
| Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities. | Front Cell Neurosci | 2026 | 42819782 | PubTator, text mining | PubMed |
| Targeting vascular inflammation and endothelial dysfunction with nanobodies: emerging therapeutic strategies for cardiovascular disease. | Front Immunol | 2026 | 42812766 | PubTator, text mining | PubMed |
| Pannexin 1 beyond the plasma membrane in neuroinflammation: An organelle-centered perspective and therapeutic opportunities. | Pharmacol Res | 2026 | 42790832 | PubTator, text mining | PubMed |
| Developmental synchrony of retinal waves, apoptosis, and angiogenesis in postnatal retina. | Elife | 2026 | 42781866 | PubTator, text mining | PubMed |
| Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes. | J Cachexia Sarcopenia Muscle | 2026 | 42773997 | PubTator, text mining | PubMed |
| Gap junctions and hemichannels in cancer: A "Wired versus Broadcast" framework for tumor microenvironment routing of cGAMP-STING signals and therapy response. | Transl Oncol | 2026 | 42743660 | PubTator, text mining | PubMed |
| SIV/HIV Induces Arachidonic Acid-Mediated Inflammation in the Heart by a Pannexin-1 Mechanism. | Am J Pathol | 2026 | 42665161 | PubTator, text mining | PubMed |
1 to 10 of 2,465
See all 2,465 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/24145
GET https://conductscience.org/api/genes/v1/24145/patents?page=2