Gene · 246243
RNASEH1: ribonuclease H1
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. RNASEH1: ribonuclease H1. Genes, record 246243. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/246243
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O60930 | Ribonuclease H1 | 286 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 61861 | O60930 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4896 | O60930 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 11472 | O60930 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7582 | O60930 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7582 | O60930 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4896 | O60930 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 11472 | O60930 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 11472 | O60930 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 11479 | O60930 | Espacenet |
| JP 2023106701 A | 2023-08-02 | 49 | O60930 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants874
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RNASEH1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD000068 | Factors Influencing Genetic Transcription Initiation And Termination | 19 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 8 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 7 | 2025 |
| R01GM119334 | Mechanisms of R-loop-Associated Genome Instability | 7 | 2025 |
| R01CA241554 | Dysregulated transcription processes in Ewing sarcoma | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| ZIABC006161 | DNA Topoisomerases as nuclear and mitochondrial targets of Anticancer Drugs | 5 | 2025 |
| ZIAES065078 | Molecular Characterization Of The Mitochondrial Dna Polymerase | 5 | 2025 |
| R01CA198279 | Shaping DNA Damage Response Networks Via Histone H2A Variants | 4 | 2025 |
1 to 10 of 874Source NIH's project files
See all 874 nih grantsPapers1,397
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Development of Antisense Gapmers for the Treatment of Huntington's Disease. | Methods Mol Biol | 2026 | 42814297 | PubTator, text mining | PubMed |
| Bepirovirsen: The first antisense oligonucleotide approved to achieve a functional cure for chronic hepatitis B. | Drug Discov Ther | 2026 | 42802047 | PubTator, text mining | PubMed |
| The DNA/RNA Helicase SETX Maintains R-Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer. | Cancer Sci | 2026 | 42713672 | PubTator, text mining | PubMed |
| SSB deficiency-induced R-loop accumulation triggers podocyte inflammation in DKD. | Front Immunol | 2026 | 42694127 | PubTator, text mining | PubMed |
| ESCRT-I complex enhances therapeutic efficacy of ASO drugs by regulating endosomal escape and glucose homeostasis. | Mol Ther Nucleic Acids | 2026 | 42662926 | PubTator, text mining | PubMed |
| An RNase domain-dependent microRNA detection with DNA-spiked nanocage for accurate cancer diagnosis. | Nat Commun | 2026 | 42660952 | PubTator, text mining | PubMed |
| Identification of Mitochondrial-Related Signature in Allergic Rhinitis: Novel Insights from Bioinformatics and Machine Learning. | J Inflamm Res | 2026 | 42609236 | PubTator, text mining | PubMed |
| α-Satellite RNA maintains centromeric cohesion through R-loops. | Mol Cell | 2026 | 42556348 | PubTator, text mining | PubMed |
| Molecular Mechanisms and Therapeutic Targets of RNA-Based and Traditional Lipid-Lowering Agents in Residual Cardiovascular Risk: A Scoping Review of Key Directions Towards Future Perspectives. | Biomolecules | 2026 | 42352274 | PubTator, text mining | PubMed |
| R-Loops Mediated Odontogenic Differentiation of hDPSCs by Activating the cGAS-STING Pathway Under Inflammatory Microenvironment. | Oral Dis | 2026 | 42286959 | PubTator, text mining | PubMed |
1 to 10 of 1,397
See all 1,397 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/246243
GET https://conductscience.org/api/genes/v1/246243/patents?page=2