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MTOR: mechanistic target of rapamycin kinase

1 protein, 142 patents, 29 drugs, 210 trials, 33,350 NIH grants and 142,439 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMTORHGNC
Namemechanistic target of rapamycin kinaseHGNC
NCBI Gene ID2475NCBI Gene
HGNC IDHGNC:3942HGNC
EnsemblENSG00000198793NCBI Gene
AliasesFLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mTORNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P42345Serine/threonine-protein kinase mTOR2,54973Ensembl, GeneID, HGNCUniProt

Patents 142

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12558356 B22026-02-241P42345Espacenet
US 12544448 B22026-02-101P42345Espacenet
US 12539305 B22026-02-031P42345Espacenet
EP 4661970 A12025-12-1762161P42345Espacenet
EP 4650780 A22025-11-197886P42345Espacenet
EP 4641201 A22025-10-297989P42345Espacenet
EP 4618968 A12025-09-2427P42345Espacenet
JP 2025522296 A2025-07-151P42345Espacenet
JP 2025517969 A2025-06-127989P42345Espacenet
JP 2025517970 A2025-06-127886P42345Espacenet

Drugs 29

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APITOLISIBCHEMBL1922094Serine/threonine-protein kinase mTOR inhibitorINHIBITORChEMBL
AZD-8055CHEMBL1801204Serine/threonine-protein kinase mTOR inhibitorINHIBITORChEMBL
BGT-226CHEMBL3545096Serine/threonine-protein kinase mTOR inhibitorINHIBITORChEMBL
BGT-226 FREE BASECHEMBL3218578Serine/threonine-protein kinase mTOR inhibitorINHIBITORChEMBL
CC-115CHEMBL3586573Serine/threonine-protein kinase mTOR inhibitorINHIBITORChEMBL
DACTOLISIBCHEMBL1879463Serine/threonine-protein kinase mTOR inhibitorINHIBITORChEMBL
DS-3078ACHEMBL3544963Serine/threonine-protein kinase mTOR inhibitorINHIBITORChEMBL
DS-7423CHEMBL3545248Serine/threonine-protein kinase mTOR inhibitorINHIBITORChEMBL
GEDATOLISIBCHEMBL592445Serine/threonine-protein kinase mTOR inhibitorINHIBITORChEMBL
INDOXIMODCHEMBL571209mTORC1 activatorACTIVATORChEMBL

Trials 210

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07558733SAPANISERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT06811116SAPANISERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT06757634GEDATOLISIBPHASE3ClinicalTrials.gov
NCT06463028SAPANISERTIBPHASE2ClinicalTrials.gov
NCT06390865SAPANISERTIBPHASE2ClinicalTrials.gov
NCT06385496SAPANISERTIBPHASE2ClinicalTrials.gov
NCT06190899GEDATOLISIBPHASE1/PHASE2ClinicalTrials.gov
NCT05501886GEDATOLISIBPHASE3ClinicalTrials.gov
NCT05354362ONATASERTIBPHASE1ClinicalTrials.gov
NCT05275673SAPANISERTIBPHASE22025-04-24ClinicalTrials.gov

NIH grants 33350

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1,1452,025NIH's project files
P30CA008748Cancer Center Support Grant8442,025NIH's project files
P30CA006973Regional Oncology Research Center2162,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award1612,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes1412,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant1282,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant1202,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase1182,025NIH's project files
P30CA016058Cancer Center Support Grant1172,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)1152,025NIH's project files

Papers 142439

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827183PubTator, text miningPubMed
42827142PubTator, text miningPubMed
42826912PubTator, text miningPubMed
42825909PubTator, text miningPubMed
42825353PubTator, text miningPubMed
42825013PubTator, text miningPubMed
42824816PubTator, text miningPubMed
42823563PubTator, text miningPubMed
42823298PubTator, text miningPubMed
42822936PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license