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Gene · 248

ALPI: alkaline phosphatase, intestinal

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ALPI: alkaline phosphatase, intestinal. Genes, record 248. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/248

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Gene

Symbol
ALPI
HGNC
Name
alkaline phosphatase, intestinal
HGNC
NCBI Gene ID
248
NCBI Gene
HGNC ID
HGNC:437
HGNC
Ensembl
ENSG00000163295
NCBI Gene
Aliases
IAP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09923Intestinal-type alkaline phosphatase5280Ensembl, GeneID, HGNC

Source UniProt

Patents89

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12648987 B22026-06-091P09923Espacenet
JP 2026516499 A2026-05-2512P09923Espacenet
JP 2026516225 A2026-05-2019P09923Espacenet
EP 4709762 A22026-03-1812P09923Espacenet
EP 4704882 A22026-03-1119P09923Espacenet
JP 2026004568 A2026-01-1437085P09923Espacenet
US 12508304 B22025-12-301P09923Espacenet
EP 4650780 A22025-11-193619P09923Espacenet
US 12472147 B22025-11-181P09923Espacenet
EP 4641201 A22025-10-293214P09923Espacenet

1 to 10 of 89

See all 89 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,273

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleALPI papersNewest fiscal year
P30CA016672Cancer Center Support Grant142025
P30CA030199Cancer Center Support Grant (CCSG)102025
P30DK034854Integrated Epithelial and Muscosal Biology92025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)92025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital92025
P01HL131474Protein Glycosylation in the Coagulopathy and Inflammation of Sepsis62025
P30CA008748Cancer Center Support Grant62025
T32DK007754Research Training in Alimentary Tract Surgery62025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant52025

1 to 10 of 1,273Source NIH's project files

See all 1,273 nih grants

Papers2,303

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Non-genetic remodeling drives leukemia propagation and reveals actionable vulnerabilities in acute myeloid leukemia.Cell Rep Med202642673946PubTator, text miningPubMed
EnView: a tunable microphysiological platform with human crypt-scale topography and independent apical-basal flow for long-term culture and imaging of colonic epithelial monolayers.Lab Chip202642614112PubTator, text miningPubMed
Redefining biologically borderline resectable pancreatic cancer: a data-driven reassessment of CA19-9 cutoff and a preoperative lymph node metastasis prediction model.Surg Today202642566027PubTator, text miningPubMed
Linker attachment points: "finishing touch" in PROTAC design.RSC Med Chem202642519712PubTator, text miningPubMed
Integrative Proteomics and Phosphoproteomics Profiling of Chronic Enteropathy Associated with SLCO2A1 Gene Reveals Mucosal Barrier Impairment and Focal Adhesion Pathway Alterations.Biomedicines202642511887PubTator, text miningPubMed
Proteome-Wide Mendelian Randomization Identifies Causal Proteins for Multiple Sclerosis Susceptibility and Severity.Genes (Basel)202642510850PubTator, text miningPubMed
Exploring the Dynamic Interplay of Carbon Nanotubes with Apoptosis In-vitro and In-vivo: Insights from Bcl-2 and IAP Families.Iran J Biotechnol202642473593PubTator, text miningPubMed
SYNGR2 as a Multifaceted Biomarker in Hepatocellular Carcinoma Linking Prognosis, Immune Microenvironment and Therapeutic Response.Technol Cancer Res Treat202642470438PubTator, text miningPubMed
From charge shifting to membrane engagement: next-generation cubosomes for enhanced intracellular drug delivery.Int J Pharm202642468653PubTator, text miningPubMed
Co-exposure to polystyrene nanoparticles and tetrabromobisphenol A induces genotoxicity and interferes with intestinal barrier differentiation.Cell Biol Toxicol202642432198PubTator, text miningPubMed

1 to 10 of 2,303

See all 2,303 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/248

GET https://conductscience.org/api/genes/v1/248/patents?page=2