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Gene · 2487

FRZB: frizzled related protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FRZB: frizzled related protein. Genes, record 2487. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2487

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Gene

Symbol
FRZB
HGNC
Name
frizzled related protein
HGNC
NCBI Gene ID
2487
NCBI Gene
HGNC ID
HGNC:3959
HGNC
Ensembl
ENSG00000162998
NCBI Gene
Aliases
FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, OS1, SFRP3, SRFP3, hFIZ
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92765Secreted frizzled-related protein 33250Ensembl, GeneID, HGNC

Source UniProt

Patents69

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026209536 A12026-10-081Q92765Espacenet
JP 2026004568 A2026-01-1446717Q92765Espacenet
EP 4650780 A22025-11-193595Q92765Espacenet
JP 2025147176 A2025-10-065562Q92765Espacenet
JP 2025529142 A2025-09-046420Q92765Espacenet
US 12371689 B22025-07-296420Q92765Espacenet
JP 2025517970 A2025-06-123595Q92765Espacenet
JP 2025028160 A2025-02-285562Q92765Espacenet
KR 1020250010750 A2025-01-215562Q92765Espacenet
JP 2024109657 A2024-08-145569Q92765Espacenet

1 to 10 of 69

See all 69 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,447

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFRZB papersNewest fiscal year
P30CA016672Cancer Center Support Grant122025
P30CA062203Cancer Center Support Grant62025
R01EY021797Development of Stem Cell-based Therapies for Limbal Stem Cell Deficiency42025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center32025
P30AG066511Goizueta Alzheimer's Disease Research Center32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025
P30CA016042Cancer Center Support Grant32025
P30EY000331Vision Research Core at UCLA32025
T32CA009056Tumor Cell Biology Training Program32025
P01CA155258Integrative Oncogenomics of Multiple Myeloma22025

1 to 10 of 1,447Source NIH's project files

See all 1,447 nih grants

Papers2,278

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Secreted frizzled-related protein 2 as a context-dependent extracellular signaling hub in development, tissue remodeling, and disease.Front Cell Dev Biol202642756375PubTator, text miningPubMed
Secreted frizzled-related protein 3 is associated with metabolic disturbances in gestational diabetes.Front Endocrinol (Lausanne)202642666239PubTator, text miningPubMed
Identification of Vital Genes Common to Dilated and Hypertrophic Cardiomyopathy Using Machine Learning and Bioinformatics.Anatol J Cardiol202642656077PubTator, text miningPubMed
Single-Cell Transcriptomic Profiling Reveals Superficial Zone Chondrocytes as a Catabolic and Senescent Focus in Osteoarthritis Cartilage.Cartilage202642647181PubTator, text miningPubMed
Multi-omics analysis of histidine metabolism reveals FRZB-CRYM-associated cellular crosstalk in heart failure.Front Cardiovasc Med202642639091PubTator, text miningPubMed
Identification and clinical evaluation of diagnostic biomarkers for ischemic cardiomyopathy based on machine learning and transcriptomics.Front Cardiovasc Med202642630293PubTator, text miningPubMed
Neurovascular-Immune Biomarkers in Ménière Disease: Insights From High-Throughput Proteomics.Otol Neurotol202642584982PubTator, text miningPubMed
Whole-Exome Analysis Identifies Candidate Genes Associated With Diabetic Retinopathy.Invest Ophthalmol Vis Sci202642417591PubTator, text miningPubMed
Automatic extraction of mesenchymal stromal cells from single-cell RNA-sequencing data of human dental pulp.BioData Min202642415183PubTator, text miningPubMed
Red-Light-Triggered In Vitro and In Vivo Photocatalytic Cancer Therapy with Polypyridyl Os(II) Photocatalysts.J Med Chem202642396916PubTator, text miningPubMed

1 to 10 of 2,278

See all 2,278 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2487

GET https://conductscience.org/api/genes/v1/2487/patents?page=2