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Gene · 249

ALPL: alkaline phosphatase, biomineralization associated

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ALPL: alkaline phosphatase, biomineralization associated. Genes, record 249. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/249

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Gene

Symbol
ALPL
HGNC
Name
alkaline phosphatase, biomineralization associated
HGNC
NCBI Gene ID
249
NCBI Gene
HGNC ID
HGNC:438
HGNC
Ensembl
ENSG00000162551
NCBI Gene
Aliases
AP-TNAP, APTNAP, HOPS, HPPA, HPPC, HPPI, HPPO, TNALP, TNAP, TNS-ALP, TNSALP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P05186Alkaline phosphatase, tissue-nonspecific isozyme5245Ensembl, GeneID, HGNC

Source UniProt

Patents177

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026516225 A2026-05-202P05186Espacenet
JP 2026516225 A2026-05-204P05186Espacenet
JP 2026516225 A2026-05-205P05186Espacenet
EP 4704882 A22026-03-112P05186Espacenet
EP 4704882 A22026-03-114P05186Espacenet
EP 4704882 A22026-03-115P05186Espacenet
JP 2026004568 A2026-01-1437088P05186Espacenet
JP 2026004568 A2026-01-1437089P05186Espacenet
JP 2026004568 A2026-01-1437090P05186Espacenet
EP 4650780 A22025-11-199532P05186Espacenet

1 to 10 of 177

See all 177 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,408

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleALPL papersNewest fiscal year
R01CA142746Subcellular enzyme-instructed self-assembly for molecular anticancer nanomedicines132025
P30CA008748Cancer Center Support Grant82025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases52025
U19AG055373Trans-omics Integration of Multi-omics Studies for Osteoporosis52025
U54GM115516Northern New England Clinical and Translational Research Network52025
ZIAAG001050The InChianti Study52025
P30DK063491Diabetes Research Center (DRC)42025
U54GM115677Advance Clinical and Translational Research (Advance-CTR)42025
UL1TR002243Vanderbilt Institute for Clinical and Translational Research (VICTR)42025
P30AR069620Michigan Integrative Musculoskeletal Health Core Center (Overall Application)32025

1 to 10 of 1,408Source NIH's project files

See all 1,408 nih grants

Papers3,295

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diagnostic Yield of Laboratory-Based Screening for Hypophosphatasia Among Chinese Children With Low Alkaline Phosphatase.J Clin Endocrinol Metab202642810859PubTator, text miningPubMed
Tissue-nonspecific alkaline phosphatase deficiency is associated with altered immune cell profiles in hypophosphatasia.Front Immunol202642807128PubTator, text miningPubMed
Synergistic Variants in C-terminal Binding Protein 1 and Alkaline Phosphatase Lead to Mandibular Hypoplasia Through Impaired Wnt Signaling: An Oligogenic Model.bioRxiv202642780217PubTator, text miningPubMed
In vitro chondrogenic differentiation is improved by the BMP7-derived peptide p[63-82].Peptides202642778025PubTator, text miningPubMed
Physicochemical performance and biological response of ready-to-use bioceramic endodontic sealers.Clin Oral Investig202642706430PubTator, text miningPubMed
Air Pollution-Associated Intracellular Metals, Immune Gene Expression, and Erythrocyte Indices in COPD with Anemia.Int J Chron Obstruct Pulmon Dis202642699267PubTator, text miningPubMed
Twist1 Promotes Endothelial Phenotypic Transition and Unstable Plaque Phenotype During Atherosclerosis.Arterioscler Thromb Vasc Biol202642689320PubTator, text miningPubMed
Adult hypophosphatasia with a single heterozygous c.572A > G p.Glu191Gly mutation in the ALPL gene: Case report.Mod Rheumatol Case Rep202642644750PubTator, text miningPubMed
Possible adult-onset hypophosphatasia variant presenting as young-onset parkinsonism with limited levodopa responsiveness.BMJ Case Rep202642608077PubTator, text miningPubMed
Magnesium-containing Calcium Silicate Sealer Modulates Bioactive Gene Expression in Immortalized Human Periodontal Ligament Stem Cells.J Endod202642595254PubTator, text miningPubMed

1 to 10 of 3,295

See all 3,295 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/249

GET https://conductscience.org/api/genes/v1/249/patents?page=2