ConductScience.org, home

Gene · 2494

NR5A2: nuclear receptor subfamily 5 group A member 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. NR5A2: nuclear receptor subfamily 5 group A member 2. Genes, record 2494. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2494

On this page

Gene

Symbol
NR5A2
HGNC
Name
nuclear receptor subfamily 5 group A member 2
HGNC
NCBI Gene ID
2494
NCBI Gene
HGNC ID
HGNC:7984
HGNC
Ensembl
ENSG00000116833
NCBI Gene
Aliases
B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F, hB1F-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00482Nuclear receptor subfamily 5 group A member 254128Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705462 A22026-03-11156O00482Espacenet
JP 2026004568 A2026-01-1456192O00482Espacenet
EP 4641201 A22025-10-298379O00482Espacenet
JP 2025147176 A2025-10-0615435O00482Espacenet
JP 2025121934 A2025-08-203O00482Espacenet
JP 2025517969 A2025-06-128379O00482Espacenet
JP 2025028160 A2025-02-2815435O00482Espacenet
KR 1020250010750 A2025-01-2115435O00482Espacenet
JP 2024109657 A2024-08-1415274O00482Espacenet
US 12024722 B22024-07-0297O00482Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,491

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNR5A2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant152025
ZIACP010193Whole Genome Scan in the Pancreatic Cancer Cohort Consortium (PanScan)102025
P30CA016672Cancer Center Support Grant82025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant72025
UG1CA189974SWOG NCORP Research Base72025
P30CA016087Cancer Center Support Grant62025
P30DK020593Vanderbilt Diabetes Research Center62025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
R01DK115213Targeting the orphan nuclear receptor LRH-1 with small molecules52025
P30CA015704Cancer Center Support Grant42025

1 to 10 of 1,491Source NIH's project files

See all 1,491 nih grants

Papers1,984

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
NRF2-Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities.Asia Pac J Clin Oncol202642802387PubTator, text miningPubMed
Microbiome-host communication via vaccenic acid modulates LRH-1/NR5A2 activity and ameliorates metabolic liver disease.EMBO Mol Med202642754660PubTator, text miningPubMed
Integrative analysis of miRNA-RBP-splicing interactions during respiratory syncytial virus infection.J Infect Dev Ctries202642566339PubTator, text miningPubMed
NR5A2 increases inflammation and cell proliferation by regulating the nuclear factor κB pathway in polyendocrine metabolic ovarian syndrome.Reprod Biomed Online202642542018PubTator, text miningPubMed
Single-blastomere transcriptomics identifies NR5A2-associated metabolic genes during porcine zygotic genome activation.Theriogenology202642497609PubTator, text miningPubMed
Multimodal C9-66 CAR-T cell immunotherapy improves outcome in preclinical models of pancreatic cancer.Gut202642457620PubTator, text miningPubMed
Corrigendum to "LRH1 promotes pancreatic cancer metastasis" [Cancer Lett. (2014) 24 350 (1-2) 15-24].Cancer Lett202642373381PubTator, text miningPubMed
HSD3B1 links ileal steroid metabolism to bile acid regulation in patients with prostate cancer.J Clin Invest202642294886PubTator, text miningPubMed
Structure-guided compound prioritization strategy for virtual screening identifies putative binders for the nuclear receptor LRH-1.bioRxiv202642282656PubTator, text miningPubMed
Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells.Cell Stem Cell202642259293PubTator, text miningPubMed

1 to 10 of 1,984

See all 1,984 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2494

GET https://conductscience.org/api/genes/v1/2494/patents?page=2