Gene · 2494
NR5A2: nuclear receptor subfamily 5 group A member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NR5A2: nuclear receptor subfamily 5 group A member 2. Genes, record 2494. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2494
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00482 | Nuclear receptor subfamily 5 group A member 2 | 541 | 28 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4705462 A2 | 2026-03-11 | 156 | O00482 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 56192 | O00482 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8379 | O00482 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15435 | O00482 | Espacenet |
| JP 2025121934 A | 2025-08-20 | 3 | O00482 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8379 | O00482 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15435 | O00482 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15435 | O00482 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15274 | O00482 | Espacenet |
| US 12024722 B2 | 2024-07-02 | 97 | O00482 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,491
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NR5A2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 15 | 2025 |
| ZIACP010193 | Whole Genome Scan in the Pancreatic Cancer Cohort Consortium (PanScan) | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 7 | 2025 |
| UG1CA189974 | SWOG NCORP Research Base | 7 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 6 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 6 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| R01DK115213 | Targeting the orphan nuclear receptor LRH-1 with small molecules | 5 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,491Source NIH's project files
See all 1,491 nih grantsPapers1,984
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| NRF2-Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities. | Asia Pac J Clin Oncol | 2026 | 42802387 | PubTator, text mining | PubMed |
| Microbiome-host communication via vaccenic acid modulates LRH-1/NR5A2 activity and ameliorates metabolic liver disease. | EMBO Mol Med | 2026 | 42754660 | PubTator, text mining | PubMed |
| Integrative analysis of miRNA-RBP-splicing interactions during respiratory syncytial virus infection. | J Infect Dev Ctries | 2026 | 42566339 | PubTator, text mining | PubMed |
| NR5A2 increases inflammation and cell proliferation by regulating the nuclear factor κB pathway in polyendocrine metabolic ovarian syndrome. | Reprod Biomed Online | 2026 | 42542018 | PubTator, text mining | PubMed |
| Single-blastomere transcriptomics identifies NR5A2-associated metabolic genes during porcine zygotic genome activation. | Theriogenology | 2026 | 42497609 | PubTator, text mining | PubMed |
| Multimodal C9-66 CAR-T cell immunotherapy improves outcome in preclinical models of pancreatic cancer. | Gut | 2026 | 42457620 | PubTator, text mining | PubMed |
| Corrigendum to "LRH1 promotes pancreatic cancer metastasis" [Cancer Lett. (2014) 24 350 (1-2) 15-24]. | Cancer Lett | 2026 | 42373381 | PubTator, text mining | PubMed |
| HSD3B1 links ileal steroid metabolism to bile acid regulation in patients with prostate cancer. | J Clin Invest | 2026 | 42294886 | PubTator, text mining | PubMed |
| Structure-guided compound prioritization strategy for virtual screening identifies putative binders for the nuclear receptor LRH-1. | bioRxiv | 2026 | 42282656 | PubTator, text mining | PubMed |
| Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells. | Cell Stem Cell | 2026 | 42259293 | PubTator, text mining | PubMed |
1 to 10 of 1,984
See all 1,984 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2494
GET https://conductscience.org/api/genes/v1/2494/patents?page=2