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ABL1: ABL proto-oncogene 1, non-receptor tyrosine kinase

1 protein, 87 patents, 36 drugs, 1,467 trials, 10,675 NIH grants and 34,797 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolABL1HGNC
NameABL proto-oncogene 1, non-receptor tyrosine kinaseHGNC
NCBI Gene ID25NCBI Gene
HGNC IDHGNC:76HGNC
EnsemblENSG00000097007NCBI Gene
AliasesABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-ablNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00519Tyrosine-protein kinase ABL11,13085Ensembl, GeneID, HGNCUniProt

Patents 87

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195486P00519Espacenet
EP 4641201 A22025-10-295100P00519Espacenet
JP 2025147176 A2025-10-0616579P00519Espacenet
EP 4623078 A12025-10-01226P00519Espacenet
EP 4623996 A22025-10-015P00519Espacenet
JP 2025531266 A2025-09-196P00519Espacenet
EP 4587819 A22025-07-236P00519Espacenet
JP 2025517969 A2025-06-125100P00519Espacenet
JP 2025517970 A2025-06-125486P00519Espacenet
JP 2025062604 A2025-04-14890P00519Espacenet

Drugs 36

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASCIMINIBCHEMBL4208229Tyrosine-protein kinase ABL inhibitorINHIBITORChEMBL
ASCIMINIBCHEMBL4208229Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
ASCIMINIB HYDROCHLORIDECHEMBL4297220Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
AT-9283CHEMBL495727Tyrosine-protein kinase ABL inhibitorINHIBITORChEMBL
AZD-0424CHEMBL5314408Tyrosine-protein kinase ABL inhibitorINHIBITORChEMBL
AZM-475271CHEMBL426161Tyrosine-protein kinase ABL inhibitorINHIBITORChEMBL
BAFETINIBCHEMBL206834Tyrosine-protein kinase ABL inhibitorINHIBITORChEMBL
BOSUTINIBCHEMBL288441Tyrosine-protein kinase ABL inhibitorINHIBITORChEMBL
BOSUTINIBCHEMBL288441Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
BOSUTINIB MONOHYDRATECHEMBL2095206Bcr/Abl fusion protein inhibitorINHIBITORChEMBL

Trials 1467

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604233ASCIMINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07559370IMATINIBPHASE2ClinicalTrials.gov
NCT07538401ASCIMINIBPHASE2ClinicalTrials.gov
NCT07538401DASATINIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07530367IMATINIBPHASE3ClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov

NIH grants 10675

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant6962,025NIH's project files
P30CA008748Cancer Center Support Grant2512,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)1682,025NIH's project files
P30CA006973Regional Oncology Research Center732,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias592,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant582,025NIH's project files
P30CA016058Cancer Center Support Grant562,025NIH's project files
P30CA033572Cancer Center Support Grant562,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant542,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase512,025NIH's project files

Papers 34797

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818859PubTator, text miningPubMed
42815640PubTator, text miningPubMed
42812292PubTator, text miningPubMed
42803180PubTator, text miningPubMed
42801758PubTator, text miningPubMed
42794727PubTator, text miningPubMed
42794529PubTator, text miningPubMed
42787271PubTator, text miningPubMed
42783235PubTator, text miningPubMed
42781115PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license