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FYN: FYN proto-oncogene, Src family tyrosine kinase

1 protein, 72 patents, 6 drugs, 225 trials, 5,533 NIH grants and 8,248 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFYNHGNC
NameFYN proto-oncogene, Src family tyrosine kinaseHGNC
NCBI Gene ID2534NCBI Gene
HGNC IDHGNC:4037HGNC
EnsemblENSG00000010810NCBI Gene
AliasesMGC45350, SLK, SYN, p59-FYNNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P06241Tyrosine-protein kinase Fyn53753Ensembl, GeneID, HGNCUniProt

Patents 72

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446812P06241Espacenet
JP 2026004568 A2026-01-1446814P06241Espacenet
WO 2025252547 A12025-12-1140P06241Espacenet
EP 4660322 A12025-12-1040P06241Espacenet
WO 2025247951 A12025-12-045P06241Espacenet
EP 4650780 A22025-11-197082P06241Espacenet
EP 4641201 A22025-10-296987P06241Espacenet
JP 2025517969 A2025-06-126987P06241Espacenet
JP 2025517970 A2025-06-127082P06241Espacenet
US 12215347 B22025-02-044P06241Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DASATINIB ANHYDROUSCHEMBL1421SRC inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885SRC inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297SRC inhibitorINHIBITORChEMBL
JNJ-26483327CHEMBL3109738Tyrosine-protein kinase FYN inhibitorINHIBITORChEMBL
TG100-801CHEMBL403989SRC inhibitorINHIBITORChEMBL
XL-228CHEMBL3545085SRC inhibitorINHIBITORChEMBL

Trials 225

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06390319DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06355037DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06336395DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06124157DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06055621DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT05993949DASATINIB ANHYDROUSPHASE1ClinicalTrials.gov
NCT05751044DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov
NCT05559008DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov
NCT05432518DASATINIB ANHYDROUSEARLY_PHASE1ClinicalTrials.gov
NCT05422885DASATINIB ANHYDROUSPHASE1/PHASE22025-03-17ClinicalTrials.gov

NIH grants 5533

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant542,025NIH's project files
P30CA008748Cancer Center Support Grant312,025NIH's project files
R01AG034924mGluR5 and Phase State Dependent Synaptic Loss in Alzheimer's Disease152,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant142,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase122,025NIH's project files
P30CA068485Cancer Center Support Grant122,025NIH's project files
P30CA086862Cancer Center Support Grant122,025NIH's project files
P20GM103449Vermont Biomedical Research Network-Vermont INBRE92,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)82,025NIH's project files
R01GM086858New Molecular Probes For Protein Kinases82,025NIH's project files

Papers 8248

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819776PubTator, text miningPubMed
42818077PubTator, text miningPubMed
42816892PubTator, text miningPubMed
42811976PubTator, text miningPubMed
42809056PubTator, text miningPubMed
42783847PubTator, text miningPubMed
42737428PubTator, text miningPubMed
42690719PubTator, text miningPubMed
42664871PubTator, text miningPubMed
42662874PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license