ConductScience.org, home

Gene · 2535

FZD2: frizzled class receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. FZD2: frizzled class receptor 2. Genes, record 2535. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2535

On this page

Gene

Symbol
FZD2
HGNC
Name
frizzled class receptor 2
HGNC
NCBI Gene ID
2535
NCBI Gene
HGNC ID
HGNC:4040
HGNC
Ensembl
ENSG00000180340
NCBI Gene
Aliases
Fz2, OMOD2, fz-2, fzE2, hFz2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14332Frizzled-25655Ensembl, GeneID, HGNC

Source UniProt

Patents78

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026183201 A12026-09-032Q14332Espacenet
WO 2026183314 A12026-09-032Q14332Espacenet
JP 2026120541 A2026-07-2259Q14332Espacenet
JP 2026082857 A2026-05-1959Q14332Espacenet
JP 2026004568 A2026-01-1446704Q14332Espacenet
EP 4650780 A22025-11-195524Q14332Espacenet
JP 2025529142 A2025-09-041639Q14332Espacenet
US 12371689 B22025-07-291639Q14332Espacenet
JP 2025517970 A2025-06-125524Q14332Espacenet
JP 2023532431 A2023-07-2879Q14332Espacenet

1 to 10 of 78

See all 78 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VANTICTUMABCHEMBL2364652Frizzled-2 antagonistANTAGONIST

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02005315VANTICTUMABPHASE1ClinicalTrials.gov
NCT01973309VANTICTUMABPHASE1ClinicalTrials.gov
NCT01957007VANTICTUMABPHASE1ClinicalTrials.gov

NIH grants1,046

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFZD2 papersNewest fiscal year
P30CA046934University of Colorado Cancer Center Support Grant62025
P30DK034854Integrated Epithelial and Muscosal Biology52025
R01NS080833Biology and Engineering of Botulinum Neurotoxins.52025
I01BX002943The role of toxins in Clostridioides difficile infection pathogenesis.32025
P30CA008748Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
R01DK062277Role of Wnt-Beta-catenin in liver development and metabolic zonation32025
R35NS105078STRUCTURAL VARIATION IN NEUROLOGICAL DISEASE32025
P30AR069589Penn Skin Biology and Diseases Resource-based Center22025
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center22025

1 to 10 of 1,046Source NIH's project files

See all 1,046 nih grants

Papers1,304

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diagnostic and mechanistic roles of miR-5584-5p in endometriosis via the FZD2-mediated Wnt/β-catenin EMT axis.Hereditas202642823710PubTator, text miningPubMed
A systems microbiology framework for reproducible multi-dataset omics integration with application to long COVID.Front Syst Biol202642755588PubTator, text miningPubMed
Expression Profiling and Transcriptional Coordination of Canonical Wnt Signaling Pathway Genes (FZD2, DVL2, and AXIN1) in Chronic Venous Insufficiency.Biomedicines202642652108PubTator, text miningPubMed
Comprehensive bioinformatics analysis identifies KYNU as a novel Helicobacter pylori -associated biomarker with prognostic and therapeutic potential in gastric cancer.Sci Rep202642365091PubTator, text miningPubMed
Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.J Biomed Mater Res B Appl Biomater202642032797PubTator, text miningPubMed
Culture-dependent baseline states and drug response programs in myxofibrosarcoma models across 2D and 3D systems.Hum Cell202642012768PubTator, text miningPubMed
Fabrication and Functional Modification Strategies of Squid Ink-Derived Nanoparticles: From Natural Melanin to Multifunctional Biomaterials.Mar Drugs202641892948PubTator, text miningPubMed
The effect of cold ischemia time on hypoxia, EMT, and apoptosis pathways in normal colon mucosa.PLoS One202641860925PubTator, text miningPubMed
Roles of RNA-binding proteins in macrophage function regulation and immunotherapy.Front Cell Dev Biol202641808933PubTator, text miningPubMed
FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy.FASEB J202641808415PubTator, text miningPubMed

1 to 10 of 1,304

See all 1,304 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2535

GET https://conductscience.org/api/genes/v1/2535/patents?page=2