Gene · 2535
FZD2: frizzled class receptor 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FZD2: frizzled class receptor 2. Genes, record 2535. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2535
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14332 | Frizzled-2 | 565 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents78
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026183201 A1 | 2026-09-03 | 2 | Q14332 | Espacenet |
| WO 2026183314 A1 | 2026-09-03 | 2 | Q14332 | Espacenet |
| JP 2026120541 A | 2026-07-22 | 59 | Q14332 | Espacenet |
| JP 2026082857 A | 2026-05-19 | 59 | Q14332 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 46704 | Q14332 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5524 | Q14332 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1639 | Q14332 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1639 | Q14332 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5524 | Q14332 | Espacenet |
| JP 2023532431 A | 2023-07-28 | 79 | Q14332 | Espacenet |
1 to 10 of 78
See all 78 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| VANTICTUMAB | CHEMBL2364652 | Frizzled-2 antagonist | ANTAGONIST |
Source ChEMBL
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02005315 | VANTICTUMAB | PHASE1 | ClinicalTrials.gov | |
| NCT01973309 | VANTICTUMAB | PHASE1 | ClinicalTrials.gov | |
| NCT01957007 | VANTICTUMAB | PHASE1 | ClinicalTrials.gov |
NIH grants1,046
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FZD2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA046934 | University of Colorado Cancer Center Support Grant | 6 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 5 | 2025 |
| R01NS080833 | Biology and Engineering of Botulinum Neurotoxins. | 5 | 2025 |
| I01BX002943 | The role of toxins in Clostridioides difficile infection pathogenesis. | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| R01DK062277 | Role of Wnt-Beta-catenin in liver development and metabolic zonation | 3 | 2025 |
| R35NS105078 | STRUCTURAL VARIATION IN NEUROLOGICAL DISEASE | 3 | 2025 |
| P30AR069589 | Penn Skin Biology and Diseases Resource-based Center | 2 | 2025 |
| P30AR073752 | Washington University Rheumatic Diseases Research Resource-based Center | 2 | 2025 |
1 to 10 of 1,046Source NIH's project files
See all 1,046 nih grantsPapers1,304
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Diagnostic and mechanistic roles of miR-5584-5p in endometriosis via the FZD2-mediated Wnt/β-catenin EMT axis. | Hereditas | 2026 | 42823710 | PubTator, text mining | PubMed |
| A systems microbiology framework for reproducible multi-dataset omics integration with application to long COVID. | Front Syst Biol | 2026 | 42755588 | PubTator, text mining | PubMed |
| Expression Profiling and Transcriptional Coordination of Canonical Wnt Signaling Pathway Genes (FZD2, DVL2, and AXIN1) in Chronic Venous Insufficiency. | Biomedicines | 2026 | 42652108 | PubTator, text mining | PubMed |
| Comprehensive bioinformatics analysis identifies KYNU as a novel Helicobacter pylori -associated biomarker with prognostic and therapeutic potential in gastric cancer. | Sci Rep | 2026 | 42365091 | PubTator, text mining | PubMed |
| Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation. | J Biomed Mater Res B Appl Biomater | 2026 | 42032797 | PubTator, text mining | PubMed |
| Culture-dependent baseline states and drug response programs in myxofibrosarcoma models across 2D and 3D systems. | Hum Cell | 2026 | 42012768 | PubTator, text mining | PubMed |
| Fabrication and Functional Modification Strategies of Squid Ink-Derived Nanoparticles: From Natural Melanin to Multifunctional Biomaterials. | Mar Drugs | 2026 | 41892948 | PubTator, text mining | PubMed |
| The effect of cold ischemia time on hypoxia, EMT, and apoptosis pathways in normal colon mucosa. | PLoS One | 2026 | 41860925 | PubTator, text mining | PubMed |
| Roles of RNA-binding proteins in macrophage function regulation and immunotherapy. | Front Cell Dev Biol | 2026 | 41808933 | PubTator, text mining | PubMed |
| FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy. | FASEB J | 2026 | 41808415 | PubTator, text mining | PubMed |
1 to 10 of 1,304
See all 1,304 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2535
GET https://conductscience.org/api/genes/v1/2535/patents?page=2