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Gene · 2537

IFI6: interferon alpha inducible protein 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IFI6: interferon alpha inducible protein 6. Genes, record 2537. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2537

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Gene

Symbol
IFI6
HGNC
Name
interferon alpha inducible protein 6
HGNC
NCBI Gene ID
2537
NCBI Gene
HGNC ID
HGNC:4054
HGNC
Ensembl
ENSG00000126709
NCBI Gene
Aliases
6-16, FAM14C, G1P3, IFI-6-16, IFI616
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09912Interferon alpha-inducible protein 61300Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-197934P09912Espacenet
JP 2025529142 A2025-09-042036P09912Espacenet
US 12371689 B22025-07-292036P09912Espacenet
JP 2025517970 A2025-06-127934P09912Espacenet
US 11884978 B22024-01-30540P09912Espacenet
US 11446398 B22022-09-2041208P09912Espacenet
US 11400116 B22022-08-022538P09912Espacenet
JP 2022524081 A2022-04-27144179P09912Espacenet
KR 1020210130270 A2021-10-297P09912Espacenet
JP 2021167336 A2021-10-217P09912Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,741

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIFI6 papersNewest fiscal year
P30AG017265USC/UCLA Center on Biodemography and Population Health92025
U19AI089992Immune signatures of vaccine responses in vulnerable populations72025
P01AI039671Costimulatory Mechanisms of Autoimmunity62025
P30CA091842Cancer Center Support Grant62025
P51OD011132Emory National Primate Research Center62025
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro62025
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy62025
UL1TR001863Yale Clinical and Translational Science Award62025
P30AI036214San Diego Center for AIDS Research (SD CFAR)52025
P30CA016042Cancer Center Support Grant52025

1 to 10 of 1,741Source NIH's project files

See all 1,741 nih grants

Papers1,927

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single-cell and bulk transcriptomic analyses define an IFI27-centered interferon-response epithelial state in bladder cancer and its transcriptional response to irradiation.Front Cell Dev Biol202642798643PubTator, text miningPubMed
IGF2-associated tumor cells and APOE-positive macrophages define an imatinib resistance-associated niche in gastrointestinal stromal tumors.Gastric Cancer202642758452PubTator, text miningPubMed
Histopathological Assessment of IFI6- and RSAD2-DNA Aptamers in Oral Squamous Cell Carcinoma: A Preliminary Study Based on In Silico Analysis.Biomedicines202642652067PubTator, text miningPubMed
IFI6 is associated with interferon activation and complement-associated immune responses in primary Sjögren's disease.Funct Integr Genomics202642552444PubTator, text miningPubMed
Dual roles of SBSN in renal cancer progression and tumor thrombus: Cell-autonomous NF-κB-CD44 axis and IFI6-driven paracrine angiogenesis.iScience202642542584PubTator, text miningPubMed
Label-free plasma proteomics reveals the regulatory mechanism of Chaige Qingsan Decoction on complement and interferon pathways against influenza.J Pharm Biomed Anal202642520626PubTator, text miningPubMed
Repeated aminoglycoside exposure activates interferon-stimulated genes in human renal proximal tubular models.Arch Toxicol202642446670PubTator, text miningPubMed
Single-cell RNA sequencing and cross-species analysis revealed the role of T cell-driven inflammatory responses in the pathogenesis of aortic dissection.BMC Cardiovasc Disord202642436415PubTator, text miningPubMed
Single-cell profiling of immune activation, dysregulation, and reconstitution in rhesus macaques after measles virus infection.J Immunol202642343163PubTator, text miningPubMed
The paradox of action: Trajectories in distress, meaning, and gene regulation following self-directed activist engagement among Black women.SSM Ment Health202642312185PubTator, text miningPubMed

1 to 10 of 1,927

See all 1,927 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2537

GET https://conductscience.org/api/genes/v1/2537/patents?page=2