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Gene · 253943

YTHDF3: YTH N6-methyladenosine RNA binding protein F3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. YTHDF3: YTH N6-methyladenosine RNA binding protein F3. Genes, record 253943. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/253943

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Gene

Symbol
YTHDF3
HGNC
Name
YTH N6-methyladenosine RNA binding protein F3
HGNC
NCBI Gene ID
253943
NCBI Gene
HGNC ID
HGNC:26465
HGNC
Ensembl
ENSG00000185728
NCBI Gene
Aliases
DF3, FLJ31657
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q7Z739YTH domain-containing family protein 35853Ensembl, GeneID, HGNC

Source UniProt

Patents10

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1918057Q7Z739Espacenet
EP 4641201 A22025-10-2922426Q7Z739Espacenet
JP 2025517969 A2025-06-1222426Q7Z739Espacenet
JP 2025517970 A2025-06-1218057Q7Z739Espacenet
US 11884978 B22024-01-30810Q7Z739Espacenet
US 11446398 B22022-09-2098272Q7Z739Espacenet
JP 2022524081 A2022-04-27201243Q7Z739Espacenet
EP 3504344 A12019-07-03999Q7Z739Espacenet
JP 2005006658 A2005-01-132908Q7Z739Espacenet
EP 1447413 A22004-08-182865Q7Z739Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants632

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleYTHDF3 papersNewest fiscal year
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal132025
R01CA186702Mechanisms of epitranscriptomic regulation in cancer92025
P30AI064518Center for AIDS Research52025
R01AI125416Defining the role of the RNA modification N6-methyladenosine during Flaviviridae virus infection52025
R35NS111631New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons52025
P30CA008748Cancer Center Support Grant42025
R01GM056927Control of Translation in Herpesvirus Infected Cells - Resubmission - 142025
T32AI007647Training Program in Mechanisms of Virus-Host Interactions42025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky32025
P30CA016059Massey Cancer Center - Cancer Center Support Grant32025

1 to 10 of 632Source NIH's project files

See all 632 nih grants

Papers2,249

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single residues within the YTHDF intrinsically disordered region control m 6 A-dependent mRNA decay.bioRxiv202642818126PubTator, text miningPubMed
YTHDF3 promotes angiogenesis in endometriosis by enhancing the translation efficiency of PFKFB3.Angiogenesis202642776305PubTator, text miningPubMed
YTHDF3 Promoted Gastric Cancer Progression by Facilitating m6A-Dependent Degradation of APC mRNA.Anal Cell Pathol (Amst)202642742540PubTator, text miningPubMed
RNA m⁶A modification and its regulatory factors are altered in granulosa cells from women with PMOS.J Assist Reprod Genet202642687053PubTator, text miningPubMed
Comprehensive Analysis of m6A Regulators Identifies YTHDF3 as a Promising Prognostic Biomarker for Breast Cancer.J Vis Exp202642612048PubTator, text miningPubMed
Ythdf family m6A readers promote retinal ganglion cell fate reprogramming and neurite development.Exp Eye Res202642595204PubTator, text miningPubMed
YTHDF3 Promotes the Progression of Gastric Cancer by Activating the Wnt/β-Catenin Signaling Pathway via Targeting NEK7.J Gastroenterol Hepatol202642533606PubTator, text miningPubMed
p53 hotspot mutants attenuate CTL-mediated tumor cell killing through a novel ALKBH5-YTHDF3-PD-L1 pathway.Oncogene202642533115PubTator, text miningPubMed
RGS16 Aggravates Hepatic Ischemia-Reperfusion Injury via Hepatocyte-Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis.Adv Sci (Weinh)202642517511PubTator, text miningPubMed
Correction: Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3.
Mol Cancer202642436539PubTator, text miningPubMed

1 to 10 of 2,249

See all 2,249 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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