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Gene · 2549

GAB1: GRB2 associated binding protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GAB1: GRB2 associated binding protein 1. Genes, record 2549. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2549

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Gene

Symbol
GAB1
HGNC
Name
GRB2 associated binding protein 1
HGNC
NCBI Gene ID
2549
NCBI Gene
HGNC ID
HGNC:4066
HGNC
Ensembl
ENSG00000109458
NCBI Gene
Aliases
DFNB26
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13480GRB2-associated-binding protein 16945Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448230Q13480Espacenet
EP 4641201 A22025-10-291720Q13480Espacenet
JP 2025517969 A2025-06-121720Q13480Espacenet
JP 2025032204 A2025-03-1128661Q13480Espacenet
EP 4461818 A22024-11-1328661Q13480Espacenet
JP 2023058610 A2023-04-2528661Q13480Espacenet
US 11446398 B22022-09-2036290Q13480Espacenet
JP 2022524081 A2022-04-27139261Q13480Espacenet
US 11078247 B22021-08-034269Q13480Espacenet
US 10677795 B22020-06-09767Q13480Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,656

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGAB1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant232025
P30CA008748Cancer Center Support Grant172025
P30CA076292Moffitt Cancer Center Support Grant102025
P30CA014051Cancer Center Support (Core) Grant92025
P30CA068485Cancer Center Support Grant72025
R01CA069202Structure/Function of Protein Tyrosine Phosphatases52025
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma52025
P30CA006973Regional Oncology Research Center42025
P30CA016058Cancer Center Support Grant42025
P30CA030199Cancer Center Support Grant (CCSG)42025

1 to 10 of 1,656Source NIH's project files

See all 1,656 nih grants

Papers2,374

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Comparative Evaluation of Immunohistochemistry With DNA Methylation Profiling for Molecular Classification of Medulloblastomas: A Single-Institution Cohort Study.Appl Immunohistochem Mol Morphol202642813612PubTator, text miningPubMed
Integrative genomic and single-cell transcriptomic analyses suggest a putative zinc transport-immune axis in Meniere's disease.Front Neurol202642775259PubTator, text miningPubMed
Molecular profiling of pediatric medulloblastoma in Kazakhstan: Genomic alterations, subgroup distribution, and survival.Brain Pathol202642707049PubTator, text miningPubMed
Inherent α-Helix Around Tyrosine 183 in the Intrinsically Disordered Tail of the Multi-Site Docking Platform Gab1.Biopolymers202642549985PubTator, text miningPubMed
Targeting the adaptor protein Gab1 overcomes MET/Src-driven alectinib resistance in ALK-rearranged NSCLC.Cell Signal202642492818PubTator, text miningPubMed
Identification of Markers on the Basis of Transcriptomic Analysis for Molecular Assignment of Medulloblastoma.Int J Mol Sci202642449993PubTator, text miningPubMed
Uncovering functional variants using a high-efficiency PE3-based screening platform.Sci Adv202642247518PubTator, text miningPubMed
Integrative circRNA landscape of intrauterine adhesions: putative ceRNA axes and circRNA-associated splicing usage linked to contractility and immunity.Front Mol Biosci202642181770PubTator, text miningPubMed
PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition.Cancer Res202642095550PubTator, text miningPubMed
Gαi1 and Gαi3 mediate IL-11-induced signal transduction and are potential therapeutic targets for LUAD.Cell Death Dis202642034606PubTator, text miningPubMed

1 to 10 of 2,374

See all 2,374 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2549

GET https://conductscience.org/api/genes/v1/2549/patents