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Gene · 2550

GABBR1: gamma-aminobutyric acid type B receptor subunit 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABBR1: gamma-aminobutyric acid type B receptor subunit 1. Genes, record 2550. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2550

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Gene

Symbol
GABBR1
HGNC
Name
gamma-aminobutyric acid type B receptor subunit 1
HGNC
NCBI Gene ID
2550
NCBI Gene
HGNC ID
HGNC:4070
HGNC
Ensembl
ENSG00000204681
NCBI Gene
Aliases
GABABR1, GABBR1-3, GB1, GPRC3A, NEDLC, hGB1a
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UBS5Gamma-aminobutyric acid type B receptor subunit 196124Ensembl, GeneID, HGNC

Source UniProt

Patents171

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199867Q9UBS5Espacenet
EP 4641201 A22025-10-2910117Q9UBS5Espacenet
JP 2025147176 A2025-10-065651Q9UBS5Espacenet
JP 2025138725 A2025-09-252513Q9UBS5Espacenet
JP 2025138725 A2025-09-252604Q9UBS5Espacenet
JP 2025138725 A2025-09-252608Q9UBS5Espacenet
JP 2025138725 A2025-09-252875Q9UBS5Espacenet
JP 2025138725 A2025-09-252889Q9UBS5Espacenet
JP 2025138725 A2025-09-252994Q9UBS5Espacenet
JP 2025138725 A2025-09-253381Q9UBS5Espacenet

1 to 10 of 171

See all 171 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARBACLOFENCHEMBL301742GABA-B receptor agonistAGONISTChEMBL
ARBACLOFEN PLACARBILCHEMBL2107312GABA-B receptor agonistAGONISTChEMBL
BACLOFENCHEMBL701GABA-B receptor agonistAGONISTChEMBL
CALCIUM OXYBATECHEMBL4594393GABA-B receptor agonistAGONISTChEMBL
LESOGABERANCHEMBL448343GABA-B receptor 1 agonistAGONISTChEMBL
MAGNESIUM OXYBATECHEMBL4594394GABA-B receptor agonistAGONISTChEMBL
OXYBATECHEMBL1342GABA-B receptor agonistAGONISTChEMBL
POTASSIUM OXYBATECHEMBL4594395GABA-B receptor agonistAGONISTChEMBL
SGS-742CHEMBL112797GABA-B receptor antagonistANTAGONISTChEMBL
SODIUM OXYBATECHEMBL1200682GABA-B receptor agonistAGONISTChEMBL

Trials128

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07596342OXYBATEPHASE2ClinicalTrials.gov
NCT07560878BACLOFENEARLY_PHASE1ClinicalTrials.gov
NCT07378046BACLOFENClinicalTrials.gov
NCT07063576BACLOFENPHASE2/PHASE3ClinicalTrials.gov
NCT07041203SODIUM OXYBATEPHASE1ClinicalTrials.gov
NCT06840652BACLOFENClinicalTrials.gov
NCT06809803SODIUM OXYBATEPHASE2ClinicalTrials.gov
NCT06792708SODIUM OXYBATEClinicalTrials.gov
NCT06564714BACLOFENPHASE4ClinicalTrials.gov
NCT06525077SODIUM OXYBATEPHASE3ClinicalTrials.gov

1 to 10 of 128

See all 128 trials

NIH grants2,477

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABBR1 papersNewest fiscal year
R01MH054137Structure and Function of Dopamine Receptors162025
R35GM128641Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation112025
R01DA036596Regulation of Neuronal GPCR Signaling92025
R01MH084894Function of GPCR heteromeric complexes in brain92025
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS92025
R01AA012404Gene Expression in the Human Alcoholic Brain82025
R01MH112205Molecular Details of Psychoactive Drug Actions82025
ZIAAA000301Integrative genetics of behavior with high throughput technologies72025
ZIADA000606Structural basis for the functions of dopamine receptors, neurotransmitter transporters, and sigma 1 receptor72025
P30CA016086Cancer Center Support Grant62025

1 to 10 of 2,477Source NIH's project files

See all 2,477 nih grants

Papers2,936

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-epitope vaccine targeting SARS-CoV-2 omicron S and N proteins promotes enhanced immunity: a computational approach.Front Immunol202642774152PubTator, text miningPubMed
dHis-Cu(II) based EPR distances at W-band: navigating the challenges of excitation.Phys Chem Chem Phys202642733347PubTator, text miningPubMed
Beyond spectral dispersion: proton line narrowing at ultra-high magnetic fields.Solid State Nucl Magn Reson202642715614PubTator, text miningPubMed
Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions.Biochemistry202642689537PubTator, text miningPubMed
Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions.bioRxiv202642619879PubTator, text miningPubMed
Functional CCR7A-mediated cellular responses are negatively modulated by the splice variant CCR7B.PLoS One202642550812PubTator, text miningPubMed
New insight into RNA biomarkers in neuropathic pain: a clinician-neuroscientist roadmap to translational testing and treatment monitoring a clinical review.Front Pain Res (Lausanne)202642534835PubTator, text miningPubMed
Functional dissection of HCMV gB's autonomous fusion activity provides insights into how polymorphisms in clinical isolates confer distinct characteristics.mBio202642439560PubTator, text miningPubMed
Visualizing and Braking Protein Ring Flips with Difluorotyrosines.Anal Chem202642423221PubTator, text miningPubMed
Evaluating the rate of hindered rotation of asparagine and glutamine side-chain amides in proteins using 'chemical-shift-averaged' ZZ-exchange NMR spectroscopy.J Magn Reson202642296766PubTator, text miningPubMed

1 to 10 of 2,936

See all 2,936 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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