Gene · 2550
GABBR1: gamma-aminobutyric acid type B receptor subunit 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABBR1: gamma-aminobutyric acid type B receptor subunit 1. Genes, record 2550. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2550
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UBS5 | Gamma-aminobutyric acid type B receptor subunit 1 | 961 | 24 | Ensembl, GeneID, HGNC |
Source UniProt
Patents171
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 9867 | Q9UBS5 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10117 | Q9UBS5 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5651 | Q9UBS5 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 2513 | Q9UBS5 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 2604 | Q9UBS5 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 2608 | Q9UBS5 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 2875 | Q9UBS5 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 2889 | Q9UBS5 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 2994 | Q9UBS5 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 3381 | Q9UBS5 | Espacenet |
1 to 10 of 171
See all 171 patentsDrugs10
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ARBACLOFEN | CHEMBL301742 | GABA-B receptor agonist | AGONIST | ChEMBL |
| ARBACLOFEN PLACARBIL | CHEMBL2107312 | GABA-B receptor agonist | AGONIST | ChEMBL |
| BACLOFEN | CHEMBL701 | GABA-B receptor agonist | AGONIST | ChEMBL |
| CALCIUM OXYBATE | CHEMBL4594393 | GABA-B receptor agonist | AGONIST | ChEMBL |
| LESOGABERAN | CHEMBL448343 | GABA-B receptor 1 agonist | AGONIST | ChEMBL |
| MAGNESIUM OXYBATE | CHEMBL4594394 | GABA-B receptor agonist | AGONIST | ChEMBL |
| OXYBATE | CHEMBL1342 | GABA-B receptor agonist | AGONIST | ChEMBL |
| POTASSIUM OXYBATE | CHEMBL4594395 | GABA-B receptor agonist | AGONIST | ChEMBL |
| SGS-742 | CHEMBL112797 | GABA-B receptor antagonist | ANTAGONIST | ChEMBL |
| SODIUM OXYBATE | CHEMBL1200682 | GABA-B receptor agonist | AGONIST | ChEMBL |
Trials128
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07596342 | OXYBATE | PHASE2 | ClinicalTrials.gov | |
| NCT07560878 | BACLOFEN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07378046 | BACLOFEN | ClinicalTrials.gov | ||
| NCT07063576 | BACLOFEN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07041203 | SODIUM OXYBATE | PHASE1 | ClinicalTrials.gov | |
| NCT06840652 | BACLOFEN | ClinicalTrials.gov | ||
| NCT06809803 | SODIUM OXYBATE | PHASE2 | ClinicalTrials.gov | |
| NCT06792708 | SODIUM OXYBATE | ClinicalTrials.gov | ||
| NCT06564714 | BACLOFEN | PHASE4 | ClinicalTrials.gov | |
| NCT06525077 | SODIUM OXYBATE | PHASE3 | ClinicalTrials.gov |
1 to 10 of 128
See all 128 trialsNIH grants2,477
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABBR1 papers | Newest fiscal year |
|---|---|---|---|
| R01MH054137 | Structure and Function of Dopamine Receptors | 16 | 2025 |
| R35GM128641 | Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation | 11 | 2025 |
| R01DA036596 | Regulation of Neuronal GPCR Signaling | 9 | 2025 |
| R01MH084894 | Function of GPCR heteromeric complexes in brain | 9 | 2025 |
| ZIADA000493 | Functional and Pharmacological Significance of Receptor Heteromers in the CNS | 9 | 2025 |
| R01AA012404 | Gene Expression in the Human Alcoholic Brain | 8 | 2025 |
| R01MH112205 | Molecular Details of Psychoactive Drug Actions | 8 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 7 | 2025 |
| ZIADA000606 | Structural basis for the functions of dopamine receptors, neurotransmitter transporters, and sigma 1 receptor | 7 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 2,477Source NIH's project files
See all 2,477 nih grantsPapers2,936
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Multi-epitope vaccine targeting SARS-CoV-2 omicron S and N proteins promotes enhanced immunity: a computational approach. | Front Immunol | 2026 | 42774152 | PubTator, text mining | PubMed |
| dHis-Cu(II) based EPR distances at W-band: navigating the challenges of excitation. | Phys Chem Chem Phys | 2026 | 42733347 | PubTator, text mining | PubMed |
| Beyond spectral dispersion: proton line narrowing at ultra-high magnetic fields. | Solid State Nucl Magn Reson | 2026 | 42715614 | PubTator, text mining | PubMed |
| Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions. | Biochemistry | 2026 | 42689537 | PubTator, text mining | PubMed |
| Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions. | bioRxiv | 2026 | 42619879 | PubTator, text mining | PubMed |
| Functional CCR7A-mediated cellular responses are negatively modulated by the splice variant CCR7B. | PLoS One | 2026 | 42550812 | PubTator, text mining | PubMed |
| New insight into RNA biomarkers in neuropathic pain: a clinician-neuroscientist roadmap to translational testing and treatment monitoring a clinical review. | Front Pain Res (Lausanne) | 2026 | 42534835 | PubTator, text mining | PubMed |
| Functional dissection of HCMV gB's autonomous fusion activity provides insights into how polymorphisms in clinical isolates confer distinct characteristics. | mBio | 2026 | 42439560 | PubTator, text mining | PubMed |
| Visualizing and Braking Protein Ring Flips with Difluorotyrosines. | Anal Chem | 2026 | 42423221 | PubTator, text mining | PubMed |
| Evaluating the rate of hindered rotation of asparagine and glutamine side-chain amides in proteins using 'chemical-shift-averaged' ZZ-exchange NMR spectroscopy. | J Magn Reson | 2026 | 42296766 | PubTator, text mining | PubMed |
1 to 10 of 2,936
See all 2,936 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2550
GET https://conductscience.org/api/genes/v1/2550/patents?page=2