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Gene · 2554

GABRA1: gamma-aminobutyric acid type A receptor subunit alpha1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRA1: gamma-aminobutyric acid type A receptor subunit alpha1. Genes, record 2554. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2554

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Gene

Symbol
GABRA1
HGNC
Name
gamma-aminobutyric acid type A receptor subunit alpha1
HGNC
NCBI Gene ID
2554
NCBI Gene
HGNC ID
HGNC:4075
HGNC
Ensembl
ENSG00000022355
NCBI Gene
Aliases
DEE19, ECA4, EIEE19, EJM, EJM5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P14867Gamma-aminobutyric acid receptor subunit alpha-145688Ensembl, GeneID, HGNC

Source UniProt

Patents122

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447219P14867Espacenet
JP 2026004568 A2026-01-1447220P14867Espacenet
JP 2026004568 A2026-01-1447221P14867Espacenet
JP 2026004568 A2026-01-1447222P14867Espacenet
JP 2026004568 A2026-01-1447223P14867Espacenet
JP 2026004568 A2026-01-1447224P14867Espacenet
EP 4650780 A22025-11-1960P14867Espacenet
EP 4641201 A22025-10-2944P14867Espacenet
JP 2025147176 A2025-10-065659P14867Espacenet
JP 2025147176 A2025-10-065660P14867Espacenet

1 to 10 of 122

See all 122 patents

Drugs81

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 81

See all 81 drugs

Trials1,244

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,344

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRA1 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).142025
R01NS105789Understanding GABAA receptor protein folding and misfolding102025
P50AA012870Center for the Translational Neuroscience of Alcoholism72025
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders62025
R28AA012725Brain Tissue Resource Center for Alcohol Research62025
P60AA010760Behavioral Genomics of Alcohol Neuroadaptation32025
UL1TR001863Yale Clinical and Translational Science Award32025
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025
ZICMH002903Procurement and Characterization of Postmortem Brain Tissue32025
P20GM103427Nebraska Research Network in Functional Genomics22025

1 to 10 of 1,344Source NIH's project files

See all 1,344 nih grants

Papers1,620

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Hederagenin Attenuates Morphine Addiction via GABAA1-Mediated Modulation of Ca2 +-CaMK-CREB Signaling in Ventral Tegmental Dopaminergic Neurons.Adv Sci (Weinh)202642801669PubTator, text miningPubMed
Discovery of H-10 as a potent and safe GABAA receptor positive allosteric modulator: A novel benzothiazine-triazole lead compound with broad-spectrum anticonvulsant activity.Eur J Med Chem202642762594PubTator, text miningPubMed
Integrated bioinformatics analysis of chromosomal deletion regions in glioblastoma identifies key genes linked to GABA(A) receptor signaling.J Biomol Struct Dyn202642752294PubTator, text miningPubMed
1,2-propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia.Animal Model Exp Med202642609016PubTator, text miningPubMed
Sublingual Zolpidem Spray for Refractory Catatonia: A Case Report.Hosp Pharm202642602209PubTator, text miningPubMed
Accurate prediction of gain- and loss-of-function missense variants in GABAA receptors.EBioMedicine202642546502PubTator, text miningPubMed
Precocious puberty in boys: current insights into etiology, genetic advances, and environmental factors.Front Endocrinol (Lausanne)202642534783PubTator, text miningPubMed
SCAP-derived exosomes restore excitatory-inhibitory balance and attenuate glutamate-induced excitotoxicity via modulation of GABAergic signaling.Neuroscience202642520916PubTator, text miningPubMed
Integrative analysis of machine learning and single-cell sequencing identifies IGHG1 as a therapeutic target for epimedium in diabetes-gastric cancer comorbidity.Biochem Biophys Res Commun202642364318PubTator, text miningPubMed
Exploratory Analysis of Genetic Variants in BDNF, GABA Receptors, and Dopaminergic Pathways with Alcohol Use Disorder in a Spanish Cohort.Int J Mol Sci202642353097PubTator, text miningPubMed

1 to 10 of 1,620

See all 1,620 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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